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Nanoparticle-based targeted drug delivery holds promise for treatment of cancers. However, most approaches fail to be translated into clinical success due to ineffective tumor targeting in vivo. Here, the delivery potential of mesoporous silica nanoparticles (MSN) functionalized with targeting ligands for epidermal growth factor receptor and C─C chemokine receptor type 2 is explored in lung tumors
The purpose with this project was to create future self-service points for Skånetrafiken. The ticket machines that are in use today are difficult to interact with and excluding to people who are sight impaired or uses a wheelchair. Since Skånetrafiken are going to implement new self-service solutions in 2019 they want suggestions on how it could be designed. We thought that this project was an exc
TV-on-Demand service has become one of the most popular Internet applications that continuously attracts higher user interests. With rapidly increasing user demand, the existing network conditions may not be able to ensure low start-up delay of video playback. Prefetching has been broadly investigated to cope with the start-up latency problem which is also known as user perceived latency. In this
This thesis addresses challenges in increasing the robustness of cloud-deployed applications and services to unexpected events and dynamic workloads. Without precautions, hardware failures and unpredictable large traffic variations can quickly degrade the performance of an application due to mismatch between provisioned resources and capacity needs. Similarly, disasters, such as power outages and
Distributed e-Infrastructure is a key component of modern BIG Science. Service discovery in e-Science environments, such as Worldwide LHC Computing Grid (WLCG), is a crucial functionality that relies on service registry. In this paper we re-formulate the requirements for the service endpoint registry based on our more than 10 years experience with many systems designed or used within the WLCG e-In
Protein therapeutics need to be formulated into an amorphous solid state to be stabilized, and this is efficiently done by spray drying together with a sugar matrix excipient. The characteristics of the produced powder are strongly dependent on process parameters, and therefore, spray drying offers the possibility of advanced particle engineering. In this thesis, trypsin was spray dried as a model
Sponge phase nanoparticles are lipid-based particles with a porous structure, forming pores with sizes up to 13 nm in diameter. These particles have been proposed for drug delivery by loading cargo within the pores, similar to how ionisable nanoparticles are used today. The larger pores could allow for larger cargo to be delivered to cells. Sponge phase nanoparticles, 277 ± 29 nm in diameter, were
The controlled delivery of micronutrients to soil and plants is essential to increase agricultural yields. However, this is today achieved using fossil fuel-derived plastic carriers, posing environmental risks and contributing to global carbon emissions. In this work, a novel and efficient way to prepare biodegradable zinc-impregnated cellulose acetate beads for use as controlled release fertilize
Coordination of Official Development Assistance (ODA) has been an important topic in debates focused on improving the outcomes of international development. The subject assumes particular importance with the expected increase of ODA flows to support developing countries addressing climate change-related issues. The case of Mozambique is of special relevance due to the heightened consequences of cl
Neurotrophic factors are candidates for treating epilepsy, but their development has been hampered by difficulties in achieving stable and targeted delivery of efficacious concentrations within the desired brain region. We have developed an encapsulated cell technology that overcomes these obstacles by providing a targeted, continuous, de novo synthesized source of high levels of neurotrophic mole
