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We present a method to first laterally position microparticles inside droplets by acoustic forces and then split the droplet into three daughter droplets to achieve a 2+fold enrichment of microparticles inside the center droplet. We show that acoustic forces can be applied to both manipulate polystyrene beads (5 μm) and red blood cells inside droplets. The presented technology opens up for develop

Traumatic brain injury (TBI) commonly results in injury to the components of the white matter tracts, causing post-injury cognitive deficits. The myelin-producing oligodendrocytes (OLs) are vulnerable to TBI, although may potentially be replaced by proliferating oligodendrocyte progenitor cells (OPCs). The cytokine interleukin-1β (IL-1β) is a key mediator of the complex inflammatory response, and

Deterministic lateral displacement (DLD) is a powerful bimodal separation scheme [1] based on regular obstacle arrays that in its basic embodiment sends particles in two different directions as a function of size. We add functionality to the technique by including gravitational forces, as a perturbation to particles transported by fluid flow, and as a way of transporting the particles through a st

Conventional fractionation techniques fail to fully benefit from the variety in morphology and shape that is found among biological particles. Although light scattering in conventional FACS gives some information on the size and morphology of a particle, it is generally not capable of giving a definite number on specified dimensions of a small object. We demonstrate an approach where we select whi

Recent studies in Drosophila have shown that heparan sulfate proteoglycans (HSPGs) are required for Wingless (Wg/Wnt) signaling. In addition, genetic and phenotypic analyses have implicated the glypican gene daily in this process. Here, we report the identification of another Drosophila glypican gene, daily-like (dly) and show that it is also involved in Wg signaling. Inhibition of dly gene activi

Trends towards distributed power generation and the deregulation of energy markets are increasing the requirement for software tools that optimize power generation plant design and operation. In this context, this paper describes the GTPOM (thermo-economic optimization of whole gas turbine plant) European project, funded in part through the European Commissions 5th Framework Programme, focusing on

We have developed a method to separate bacteria from red and white blood cells (henceforth collectively called blood cells) using acoustophoresis, for subsequent PCR detection. To maximize throughput, we have now investigated the effect of increased cell concentration on the separation. Increasing the blood concentration drastically decreases bacteria recovery, but we show that this can be remedie

Healthcare inequality is ubiquitous globally, but the effects are most striking in low-resource settings. In these settings, current methods for the design of medical devices are failing to address specific needs. The associated publications rarely describe how the context was studied at the front-end of design. There is a latent need for a holistic contextual framework for guiding the design deci

In ESS, a pulsed proton beam of 5 MW mean power will hit a tungsten target to generate neutrons by spallation. The pulses are 2.86 ms long and occur with 14 Hz; the power within a pulse is 125 MW. Only centimeters from the target, the neutrons are moderated by liquid hydrogen in aluminium vessels. The deposited power heats the surrounding structures and fluids which are circulated and cooled. The

Ta några ingenjörsstudenter, släng in ett par kognitionsvetarstudenter och ge dem ett problem att lösa. Ut kommer interaktiva dataspel för skolan och robotar som kan imitera människors rörelser. – Vi kombinerar doing och thinking, säger Agneta Gulz, professor i kognitionsvetenskap.

Cardiac arrest effectiveness trials have traditionally reported outcomes that focus on survival. A lack of consistency in outcome reporting between trials limits the opportunities to pool results for meta-analysis. The COSCA initiative (Core Outcome Set for Cardiac Arrest), a partnership between patients, their partners, clinicians, research scientists, and the International Liaison Committee on R

Cardiac arrest effectiveness trials have traditionally reported outcomes that focus on survival. A lack of consistency in outcome reporting between trials limits the opportunities to pool results for meta-analysis. The COSCA initiative (Core Outcome Set for Cardiac Arrest), a partnership between patients, their partners, clinicians, research scientists, and the International Liaison Committee on R

Are there such things as moral, rights and an inner sense of justice? Do they origin from God or are they something given by nature? If there are such things, should they be a part of the legal system? This essay has drawn its inspiration from this kind of thoughts and how they have been handled through history. The structure of the essay is two-folded. Part one is a historical review of the eme

Objective Intrauterine growth restriction (IUGR) is a recognized risk factor for neurological deficits later in life. Abnormal fetal blood flow in the presence of IUGR helps to distinguish fetuses with true growth impairment from those that are small but normally grown. This study aimed to evaluate the influence of IUGR with abnormal fetal blood flow on cognitive function and psychological develop

Background: The variation in retinal nerve fibre layer thickness (RNFLT) as measured by Stratus optical coherence tomography (OCT) in healthy subjects may be reduced when the effect on RNFLT measurements of factors other than disease is corrected for, and this may improve the diagnostic accuracy in glaucoma. With this perspective we evaluated the isolated and combined effects of factors potentiall

Syftet med detta examensarbete är att pressentera ett antal tekniska lösningar för att förbättra säkerheten och kapaciteten i ställverk 59. Ställverk 59 är den vanligaste ställverkstypen på Trafikverkets järnvägsnät. Grundkonstruktionen är utvecklad på 1950-talet, men ställverkstypen nybyggs fortfarande trots konstruktionens ålder. Ända sedan järnvägen infördes har det funnits behov av att styra t