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PURPOSE: The DIANA study aimed to evaluate how often antimicrobial de-escalation (ADE) of empirical treatment is performed in the intensive care unit (ICU) and to estimate the effect of ADE on clinical cure on day 7 following treatment initiation.METHODS: Adult ICU patients receiving empirical antimicrobial therapy for bacterial infection were studied in a prospective observational study from Octo

Generation of neurons from patient fibroblasts using a combination of developmentally defined transcription factors has great potential in disease modelling, as well as ultimately for use in regeneration and repair. However, generation of physiologically mature neurons in vitro remains problematic. Here we demonstrate the cell-cycle-dependent phosphorylation of a key reprogramming transcription fa

A series of phosphorylated test peptides was studied by electron capture dissociation Fourier transform ion cyclotron resonance mass spectrometry (ECD FT-ICR MS). The extensive ECD-induced fragmentation made identification of phosphorylation sites for these peptides straightforward. The site(s) of initial phosphorylation of a synthetic peptide with a sequence identical to that of the phosphorylati

25MOD_Flipped_artikel LTH:s 12:e Pedagogiska Inspirationskonferens, 7 december 2023 Abstrakt—Under 2021 och 2022 gavs kursen FMAB65 Endimensionell Analys B1 med två olika pedagogiska metoder: en traditionell metod, där den lärarledda undervisningen bestod av föreläsningar och räkneövningar, och en experimen- tell metod med aktivt lärande, där fokus var på grupp- seminarier, i vilka studenterna eft

https://www.lth.se/fileadmin/cee/genombrottet/konferens2023/B4_Hartman_etal.pdf - 2026-05-15

Background: Long-term recovery following critical COVID-19 has not been sufficiently studied. Objective: The primary objective was to describe changes in functional outcome and Health-Related Quality of Life (HRQoL) between 3 and 12 months in critically ill COVID-19 survivors. The secondary objective was to investigate factors associated with good functional outcome and HRQoL at 12 months. Methods

Purpose: To assess the performance of a 4-step algorithm for neurological prognostication after cardiac arrest recommended by the European Resuscitation Council (ERC) and the European Society of Intensive Care Medicine (ESICM). Methods: Retrospective descriptive analysis with data from the Target Temperature Management (TTM) Trial. Associations between predicted and actual neurological outcome wer

BACKGROUND: Studies of cancer risk among relatives of children with cancer beyond parents and siblings are limited. We have investigated the cancer risk up to the third degree of relation in families with pediatric cancer to reveal patterns of inheritance.METHODS: A single-center cohort of 757 pediatric cancer patients was linked to the Swedish National Population Register, resulting in 16 137 rel

Background Indications with poor T-cell infiltration or deficiencies in T-cell priming and associated unresponsiveness to established immunotherapies represent an unmet medical need in oncology. CD40-targeting therapies designed to enhance antigen presentation, generate new tumor-specific T cells, and activate tumor-infiltrating myeloid cells to remodel the tumor microenvironment, represent a prom

Background: Tracheal intubation is a high-risk procedure in the critically ill, with increased intubation failure rates and a high risk of other adverse events. Videolaryngoscopy might improve intubation outcomes in this population, but evidence remains conflicting, and its impact on adverse event rates is debated. Methods: This is a subanalysis of a large international prospective cohort of criti

Division of Solid Mechanics ISRN LUTFD2/TFHF11/5159SE (1-97) INVERSE MODELING OF POLYMER MATERIALS Master's Dissertation by Kent Bengtsson and Andreas Holmgren Supervisors Lic. Tech. Anders Harrysson, Tetra Pak, Lund Ph. D. Mathias Wallin, Div. of Solid Mechanics, Lund Examiner Prof. Matti Ristinmaa, Div. of Solid Mechanics, Lund Copyright c© by Div. of solid Mechanics, Tetra Pak, Kent Bengtsson a

https://www.solid.lth.se/fileadmin/hallfasthetslara/utbildning/examensarbete/TFHF5159.pdf - 2026-05-14

Master’s Dissertation Structural Mechanics PETER PERSSON ANALYSIS OF VIBRATIONS IN HIGH-TECH FACILITY Denna sida skall vara tom! Copyright © 2010 by Structural Mechanics, LTH, Sweden. Printed by Wallin & Dalholm Digital AB, Lund, Sweden, June, 2010 (Pl). For information, address: Division of Structural Mechanics, LTH, Lund University, Box 118, SE-221 00 Lund, Sweden. Homepage: http://www.byggmek.l

https://www.byggmek.lth.se/fileadmin/byggnadsmekanik/publications/tvsm5000/web5164.pdf - 2026-05-14

Virtual Clinical Trials (VCT) are an effective tool to evaluate the performance of novel imaging systems using computer simulations. VCT results depend on the selection of virtual patient populations. In the case of breast imaging, virtual patients should be matched to a desired clinical population in terms of selected anatomical or demographic descriptors. We are developing a virtual population o

Depression is a common, recurrent disorder. There is a need for readily available treatments with few negative side effects, that demands little resources and that are effective both in the short- and long term. Our aim was to investigate the long-term effectiveness of two different interventions; physical exercise and internet-based cognitive behavioural therapy (internet-CBT), compared to usual

FORSKARE: Maria Rosvall1,3, Martin Lindström1,3, Farhad Ali Khan1,3, Ellinor Bengtsson2 , Margareta Dahlén Nord2, Anna Friberg2, Mathias Grahn1, Birgit Modén1,3, Kontie Moussa1,3, Per-Olof Östergren1,3 Juan Merlo1,3 KLINIK/INSTITUTION: 1Socialmedicinska enheten, Universitets- sjukhuset MAS, 2Centrum för folkhälsa och miljö i Region Skåne, 3Inst. för kliniska vetenskaper – Malmö, Lunds universitet

https://www.vetenskaphalsa.se/wp-content/uploads/2010/01/09.MariaRosvall_hur-m%C3%A5r-sk%C3%A5ne1.pdf - 2026-05-15

Purpose: To assess the ability of clinical examination, blood biomarkers, electrophysiology or neuroimaging assessed within 7 days from return of spontaneous circulation (ROSC) to predict good neurological outcome, defined as no, mild, or moderate disability (CPC 1–2 or mRS 0–3) at discharge from intensive care unit or later, in comatose adult survivors from cardiac arrest (CA). Methods: PubMed, E

We present a Raman study of axially heterostructured InP/InGaP nanowires (NWs) for tandem solar cells. The study is carried out using both microRaman spectroscopy (µ-Raman), and tip enhanced Raman spectroscopy (TERS). The results obtained by both methods are compared. The results obtained with each one is supported by the simulation of the light/NW interaction using finite element methods. This si

Russ et al. show that human astrocytes adopt different reactive immune phenotypes when exposed to either TNF-α or alpha-synuclein fibrils, which are exogenous stressors that compete to drive the astrocyte immune reactive response. They also show that PARK2-variant-containing astrocytes exhibit an exacerbated response to the stressors, accompanied by bioenergetic defects.

This study presents how sequential infiltration synthesis of trimethyl aluminium and water into a carbohydrate-based block copolymer was used to enable pattern transfer of 6 nm half-pitch horizontal cylinders into silicon. Specular neutron reflectometry measurements of poly(styrene)-block-maltoheptaose self-assembled into horizontal cylinders indicate an increasing content of alumina after each se

Background: Pre-eclampsia (PE) is a major pregnancy disorder complicating up to 8% of pregnancies. Increasing evidence indicates a sex-specific interplay between the mother, placenta and fetus. This may lead to different adaptive mechanisms during pregnancy. Methods: We performed an individual participant data meta-analysis to determine associations of fetal sex and PE, with specific focus on gest