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Here, we describe the generation of an induced pluripotent stem cell (iPSC) line, from a male patient diagnosed with Parkinson's disease (PD). The patient carries a heterozygous variation p.A53T in the SNCA gene. Skin fibroblasts were reprogrammed using the non-integrating Sendai virus technology to deliver OCT3/4, SOX2, c-MYC and KLF4 factors. The generated iPSC line (CSC-32) preserved the mutati

Estimating age distributions, or star formation histories, of stellar populations in the Milky Way is important in order to study the evolution of trends in elemental abundances and kinematics. We build on previous work to develop an algorithm for estimating the age-metallicity distribution which uses the full age-metallicity probability density functions (PDFs) of individual stars. No assumptions

BACKGROUND: Neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), and total-tau protein (tau) are novel blood biomarkers of neurological injury, and may be used to predict outcomes in critical COVID-19.METHODS: A prospective multicentre cohort study of 117 consecutive and critically ill COVID-19 patients in six intensive care units (ICUs) in southern Sweden between May and Novem

The food industry stands as one of the most vital manufacturing sectors globally, with an ever-increasing reliance on digitalization and technology-driven processes. However, this advancement comes with an inherent risk of cyberattacks, encompassing data breaches and system disruptions, which can severely impact production and disrupt the entire food supply chain. Consequently, such cyberthreats c

Preeclampsia is a severe pregnancy-related inflammatory disease without an effective treatment. The pathophysiology remains partly unknown. However, an increased inflammatory response and oxidative stress are part of the maternal systemic reaction. Recent data have suggested that dysbiosis of the gut microbiome plays a role in preeclampsia as well as other inflammatory diseases. However, dysbiosis

Quantitative magnetic resonance imaging (MRI)-based biomarkers, which capture physiological and functional tumor processes, were evaluated as imaging surrogates of early tumor response following chemoradiotherapy in glioma patients. A multiparametric extension of a voxel-based analysis, referred as the parametric response map (PRM), was applied to quantitative MRI maps to test the predictive poten

This study contains a series of laboratory experiments designed to describe the lateral movement and spatial variability of an infiltrated dye tracer across the capillary fringe of homogenous sand in an aquarium. A combination of image analysis and geoelectrical monitoring was used to track the flow paths of the dye with different hydraulic gradients and infiltration rates. Photographs were taken

Introduction: In palliative care, family caregivers are often faced with experiences of grief in anticipation of the loss of a close person. An instrument designed to measure this form of grief is the Anticipatory Grief Scale, which includes 27 items and has been used in several studies in various contexts. However, the instrument has not been validated. Aim: The aim was to evaluate the psychometr

Arbetsdomstolens partsammansättning har länge ifrågasatts. Fyra av sju ledamöter utnämns på förslag av centrala arbetsmarknadsorganisationer. Denna sammansättning är en konsekvens av att den svenska arbetsrättsliga lagstiftningen utgår ifrån den s.k. svenska modellen med kollektivavtalsbärande centrala arbetsmarknadsorganisationer som legala representanter för arbetsmarknadens parter. I den juridiThe composition of the Swedish Labour Court with members representing the interests of employers and employees has been questioned since long. Four out of seven members are appointed and mandated on proposals of central labour market organizations (this members are hereinafter referred to as “interest members”). This composition is an effect of the fact that the Swedish labour legislation assumes

Since EU’s expansion to incorporate former Communist countries, attempts to solve the so-called “Roma issue” spurred an unprecedented array of policies, interventions and measures at national and transnational level. Instead of the expected positive changes, discrimination and poverty worsened. The current migration waves, economic crisis, and the surge of far-right nationalism, contributed to an

Ett varumärkesrättsligt skydd är ofta något som företag arbetar hårt för att uppnå. I vissa fall kan ett varumärke anses ha ett ekonomiskt värde i sig. Den tekniska utvecklingen har medfört ett förändrat samhällsklimat där individer getts ett allt större utrymme att utrycka sig. Ett förhållandevis nytt fenomen är influencers – personer som via internetplattformar använder sin egen person för att mA trademark protection is often something that companies work hard for. In some cases, a trademark may be considered to have an economic value in itself. The technological development has led to a changed social climate in which individuals are given an increasing amount of space to express themselves. A relatively new phenomenon is influencers – people who, via internet platforms, use their own p

Syftet med denna kvantitativa studie var att följa upp extremt för tidigt födda (före vecka 29) när de nått vuxen ålder. De extremt för tidigt födda jämfördes med en kontrollgrupp bestående av jämnåriga födda i fullgången tid. Deltagarna i studien hämtades från en uppföljningsstudie av extremt för tidigt födda som tidigare följts upp vid 10 och 18 års ålder. Deltagarna var vid tiden för studien 27The aim of this quantitative study was to follow up children born extremely preterm (before week 29) in adulthood. The group of extremely preterm adults was compared to peers born at term. The extremely preterm and the control group have previously been followed up at ages 10 and 18. At the time of this study the participants were 27-28 years old. Questionnaires were sent to the two groups and 77

Världen förändras kontinuerligt. Företag arbetar idag hårt för att hålla jämna steg med omvärlden för att på så vis hålla sig konkurrenskraftiga. Att arbeta för att hitta nya affärsmöjligheter har blivit av allt större betydelse. IKEA är ett globalt företag som står inför en enorm tillväxt för att nå deras mål till år 2020. För att klara denna tillväxt och för att kunna säkra försörjningen till nyThe world is continuously changing. Today many companies work hard to keep up with the surrounding world to stay competitive. To work with finding new business opportunities has become of higher importance than ever. IKEA is a global company facing a tremendous growth to reach their goal for 2020. To manage this growth and be able to secure supply to new retail markets, the company needs to increa