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Parkinson's disease (PD) is a neurodegenerative disease with unknown etiology. Here we show the generation of an induced pluripotent stem cell (iPSC) line, named CSC-40, from dermal fibroblasts obtained from a 59-year-old male patient with a homozygous p.Q456X mutation in the PTEN-induced putative kinase 1 (PINK/PARK6) gene and a confirmed diagnosis of PD, which could be used to model familial PD.

Purpose: To investigate the inflammatory response of current and future potential vitreous substitutes in an experimental in vivo vitrectomy model. Methods: Twenty-five gauge pars plana vitrectomy was performed in the right eye of 60 pigmented rabbits, with subsequent injection of 0.5–1.0 ml of Healaflow® (cross-linked hyaluronic acid, n = 12), Bio-Alcamid® (polyalkylimide, n = 8), silicone oil (n

People with severe self-harming behavior and histories of lengthy psychiatric inpatient admissions can represent a challenge to care providers. This interview-based study illuminates healthcare provider experiences (n = 12) of Brief Admission (BA) among self-harming individuals, with >180 days of psychiatric admission the previous year. Qualitative content analysis revealed that providers experien

The current study aims to computationally evaluate the effect of right upper arm position on the geometric and hemodynamic characteristics of the brachial artery (BA) and cephalic vein (CV) and, furthermore, to present in detail the methodology to characterise morphological and hemodynamical healthy vessels. Ten healthy volunteers were analysed in two configurations, the supine (S) and the prone (

Purpose: Elevated copeptin, a vasopressin marker, is linked to metabolic disease, and obese rats with low-vasopressin concentration had a decreased risk of liver steatosis. We here investigated the association between copeptin and nonalcoholic fatty liver disease (NAFLD) and possible differences in copeptin concentration between ethnicities. Methods: In this cross-sectional study of 361 South Afri

Post-cardiac arrest brain injury (PCABI) is caused by initial ischaemia and subsequent reperfusion of the brain following resuscitation. In those who are admitted to intensive care unit after cardiac arrest, PCABI manifests as coma, and is the main cause of mortality and long-term disability. This review describes the mechanisms of PCABI, its treatment options, its outcomes, and the suggested stra

This chapter concerns disabled people’s experiences of barriers to accessing sexuality. It draws on an analysis of materials produced in ten projects by civil society organisations, including self-advocacy organisations, sexual rights organisations and organisations working on behalf of disabled people. These materials comprise books, handbooks, videos, websites and other online materials, and are

The use of radio signal for position tracking (positioning) and navigation has a long tradition. Most notably, global navigation satellite systems (GNSS) are now widely applied for civilian applications, ranging all the way from tracking of cargo containers to gaming. However, GNSS suffers from limited coverage in dense urban areas and indoors and also from a limited position accuracy, which rules

AimsWe aimed to investigate the association between the exercise systolic blood pressure (SBP) response and future hypertension (HTN) in normotensive individuals referred for cycle ergometry, with special regard to reference exercise SBP values and exercise capacity.Methods and resultsIn this longitudinal cohort study, data from 14 428 exercise tests were cross-linked with Swedish national registr

Background: Swedish healthcare is in a period of transition with an expanding private sector. This study compares quality of outcome after groin hernia repair performed in a public or private healthcare setting. Methods: A cohort study based on data from the Swedish National Hernia Register combined with Patient-Reported Outcome Measures (PROMs) 1 year after groin hernia repair. Between September

Flowing water impacts bridges over rivers primarily in two ways: (1) hydrodynamic forces that directly impact the structure and (2) scouring at piers and abutments, including contraction scour. The design prin-ciples for bridges in Sweden, including both impacting forces and local scour, are relatively simplistic. The purpose of this paper is to examine the impact of extreme river flows on bridges

Background: Treatment of common bile duct (CBD) stones after Roux-en-Y gastric bypass (RYGB) poses a particular challenge given the altered anatomy and inability to perform a standard endoscopic retrograde cholangiogram (ERC). The optimal treatment strategy for intraoperatively encountered CBD stones in post-RYGB patients has not been established. Objectives: To compare outcomes following laparosc

Field delineation is important in bibliometrics. Particularly when measuring scientific performance, the demarcation of the area, to which a science actor belongs, is of the greatest importance. This paper present a method based on searches on Boolean combinations of medical subject headings (MeSH-terms) in a combined Web of Science (WoS) - Medline database. The construction of the MeSH area defin