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Methylation of lysine (Kme) is known to regulate several important functions, altering gene expression and cell cycle progression. However, mass spectrometry based proteomic analysis of the modification has not been possible due to the lack of efficient purification strategies to enrich modified peptides for analysis. In this study, we identified and evaluated several in-house and commercial candi
Canada is one of the only nations in the world that offers universal health coverage that excludes outpatient prescription drug services. This means that citizens may find out their diagnosis free of charge, but must incur out-of-pocket expenses for prescription drugs dispensed outside of hospitals. This paper examines the prevalence of prescription drug coverage in Canada across various socioecon
Background and purpose: During radiotherapy, rectal cancer patients show inter-fractional internal motion that effects the delivered dose distribution. The purpose of this work is to study I) the inter-fractional bladder volume change, II) the effect of bladder volume change on bowel dose distribution, III) the effect of bladder optimization on the relationship between bladder volume and bowel dos
Over the last decade, financial disclosure and its impact on equity markets has increasingly become an area of interest. Firms suffering from poor operating performance have been shown to disclose bias earnings estimates as a means of evading negative market reactions. In this thesis, we attempt to discern whether managers purposefully bias their earnings estimates in periods of credit quality det
The interest of this research lies in the nexus between the state and the individual in providing social care for people searching asylum in Finland. The study explores the experiences of host families involved in offering home accommodation for asylum seekers. More specifically, it aims to understand the subjective role that host families assign to themselves when providing social care for this t
This thesis presents a comparison between implementations of the inverse square root function, using two approximation algorithms; Harmonized Parabolic Synthesis and the Newton-Raphson Method. The input is a 15 bit fixed-point number, the range of which is selected so that the implementation is suitable for use as a block implementing the inverse square root for floating-point numbers, and the des
The aim of this thesis has been to investigate the legal conditions and process for triggering Credit Default Swaps, which are derivative instruments to shift credit risk exposure between parties in an underlying financial instrument. The condition is called credit event and a case study has been done on the Greek credit event in 2012. The thesis shows that there is a clear and robust framework o
Previous studies indicated that skylights can improve the daylight conditions in house or office buildings, decrease the electricity demand for lighting, provide natural ventilation and reduce the heating demand through passive solar heat gain exploitation. This thesis analyses the effect of skylights on the energy use, daylight conditions and thermal comfort in a classroom. The study is performed
This essay addresses the needs of so called ‘climate migrants’. It focuses exclusively on the relocation of the population of Kiribati, a small island nation in the Pacific Ocean whose very existence is threatened by the effects of climate change. With the principles of causality, morality, capacity and community, Miller’s Connection Theory provides the study with a framework for discussing the di
The demand for high data rates in a wireless communication system has experienced a remarkable growth over the last years. This demand is continually increasing with the growing number of wirelessly connected devices. Thus, there is a continuing hunt for increasing the data transmission rate in wireless communication systems. To increase the data rate, the modern wireless communication system cann
Though the diffusion of electric vehicle (EV) is high on the global agenda, and there are efforts to speed up the shift: some countries intend to ban the sale of internal combustion engine vehicles (ICEV), and some OEMs (original equipment manufacturers) have announced the goal of electrification, the diffusion of EV is slowly. Technological innovation theory explains that we need to harmonise tec
This thesis is a conceptual study focused on the relationship between populism and conspiracy theories to see if populism poses a totalitarian threat to democracy. Starting with a discussion on democracy and populism, this thesis examines the relations between conspiracy theories and populism as well as their respective constructions. Thereafter, departing from Hannah Arendt’s book the Origins of
This thesis aims at defining the improvement areas for packaging and logistics of a long shelf-life Danone Nutricia aseptic product. By literature research and interview, the author is able to build a product mapping protocol to define the sensitive components requiring particular concerns on packaging and logistics. This protocol could be implemented in both academic researches and industry proje
Purpose: The purpose of the study was to understand the key managerial challenges associated with Big Data. The research aimed to look at the possible obstacles that managers need to overcome while implementing Big Data. The main research question is : What are the main managerial challenges associated with Big Data and what steps are needed to overcome those? Methodology: Based on the concepts of
The incineration furnace at National Veterinary Institute (SVA) in Uppsala, Sweden, runs approximately 2,150 hours a year and generates a large amount of waste heat. Some of this heat is partially recovered, and is used for heating one of the main buildings during the furnace operation. However, around 2,000 MWh is wasted annually due to unavailability of any storage system. This wasted heat is ap
Peptides are abundant in all living organisms and essential to many cellular functions. For this purpose, peptides are interesting research targets. The chemical moieties and molecules that are involved in peptide interactions and systems, respectively, are intrinsically non-emissive or weakly emissive, which is why researchers have found strategies for labeling peptides. Today, peptides are typic
The striatum is the main input nucleus of the basal ganglia. Striatal subregions, which play different roles in motor functions, receive inputs from different cortical regions. Regulation of synaptic plasticity at the level of corticostriatal synapses is believed to underlie habit formation and motor learning. Alteration of plasticity at the level of corticostriatal synapses has been associated wi
This thesis examines the phenomena of third-party enforcement in public international law, in a historical as well as in a contemporary perspective. To that end, it traces the role of such enforcement measures from the past into the present. It also studies the potential discrepancies between current unilateral sanctions and the recent changes experienced by international law at large. Two legal m
Uppsatsen undersöker den internationella straffrättens förväntningar på ansvarighållandet av företagsledare på individnivå. Vidare utreds huruvida nationell rätt, här svensk rätt i jämförelse med tysk, uppfyller de krav och förväntningar som den internationella straffrätten ställer på nationell reglering. Dessutom syftar uppsatsen till att sätta svensk reglering av medverkansansvar för företagsledThe thesis investigates the expectations of international criminal law on the prosecution of corporate leaders on an international and domestic level for international crimes based on the sources, purposes, and principles guiding international criminal law. Also, this thesis examines whether domestic law, here Swedish, is compliant with the obligations and expectations presented by international c
