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Many common diseases are known to have genetic components, but since they are non-Mendelian, i.e. a large number of genetic factors affect the phenotype, these components are difficult to localize. These traits are often called complex and analysis of siblings is a valuable tool for mapping them. It has been shown that the power of the affected relative pairs method to detect linkage of a disease
Recent studies implicated the existence of adult lymphoid-primed multipotent progenitors (LMPPs) with little or no megakaryocyte-erythroid potential, questioning common myeloid and lymphoid progenitors as obligate intermediates in hematopoietic stem cell (HSC) lineage commitment. However, the existence of LMPPs remains contentious. Herein, global and single-cell analyses revealed a hierarchical or
Organic farming may contribute substantially to future agricultural production worldwide by improving soil quality and pest control, thereby reducing environmental impacts of conventional farming. We investigated in a comprehensive way soil chemical, as well as below and aboveground biological parameters of two organic and two conventional wheat farming systems that primarily differed in fertiliza
Originally cloned from hematopoietic stem cell (HSC) populations and its ligand being extensively used to promote ex vivo HSC expansion, the FMS-like tyrosine kinase 3 (FLT3; also called FLK2) receptor and its ligand (FL) were expected to emerge as an important physiologic regulator of HSC maintenance and expansion. However, the role of FLT3 receptor and ligand in HSC regulation remains unclear an
Background: Electroencephalography (EEG) is widely used to assess neurological prognosis in patients who are comatose after cardiac arrest, but its value is limited by varying definitions of pathological patterns and by inter-rater variability. The American Clinical Neurophysiology Society (ACNS) has recently proposed a standardized EEG-terminology for critical care to address these limitations. I
Popular Abstract in Swedish Syftet är att dels studera olika ventilationssystems förmåga att tillföra och föra bort luftflöden. Den andra delen av syftet är att studera konstruktionskriterier och energi användning för ett variabelflödessystem baserat på konstanttryckshållning av det statiska trycket på grenkanalnivå och som endast tillför uteluft. Ventilationssystemens luftflöden studeras med hjälOne part of the objective is to analyze how different ventilation systems perform in practice when it comes to supplying and exhausting designed air flow in different outdoor and indoor conditions. The other part is to analyze the design criterias and the energy use of a variable air volume system based on controlled static pressure at the branch duct level and supplying outdoor air only. To inves
1 The effectiveness of antimuscarinic agents in the treatment of the overactive bladder (OAB) syndrome is thought to arise through blockade of bladder muscarinic receptors located on detrusor smooth muscle cells, as well as on nondetrusor structures. 2 Muscarinic M-3 receptors are primarily responsible for detrusor contraction. Limited evidence exists to suggest that M-2 receptors may have a role
The article deals with stabilisation and regeneration of CeO2 and CeO2/ZrO2 based Pt water gas shift catalysts, subject to high initial deactivation. The reaction gas species effect on the catalyst deactivation was investigated by H2-TPR. Activity measurements enabled the effect of different promoters, some added to the CeO2 based catalysts and some to the CeO2/ZrO2 based Pt catalysts, to be inves
The Swedish consumer magazine Råd & Rön (”Advice and Results”) has been available to Swedish consumers since 1958. For a major part of this time the Swedish state, represented by Konsumentverket (the Swedish Consumer Agency) and its predecessor, Konsumentinstitutet (the National Institute for Consumer Information), was the owner of the magazine. In 2006 Råd & Rön was sold to the independen
I år var andra gången som Lunds universitet genomförde en universitetsgemensam pedagogisk utvecklingskonferens, första gången var 2007. Konferensen, som är ett samarrangemang mellan samtliga fakulteter och CED, har nu alltså blivit en återkommande aktivitet! Samhällsvetenskapliga fakulteten stod värd för årets konferens och dekanus Ann-Katrin Bäcklund sträckte vid invigningen fram en symbolisk sta
Desalination can be a cost-effective way to produce fresh water and possibly electricity. The Gaza Strip has had a complex hydro-political situation for many years. Gaza is bordered by the Mediterranean in the west, by Israel in the north and east and by Egypt in the south. Water and electricity consumption in the Gaza Strip is expected to increase in the future due to the increasing population.
Chondroitin (CS) and dermatan sulphate (DS) are socalled glycosaminoglycans (GAG) that are covalently attached to various type of proteins forming a subgroup within the diverse proteoglycan (PG) family. The PGs studied in this thesis are mostly extracellularly located and include aggrecan, biglycan and decorin. The CS and DS chains both consist of repeating disaccharides of the type (hexuronic aci
Popular Abstract in Swedish Kolhydrater är viktiga inte bara som bränsle och strukturgivande egenskaper, vilket var uppfattningen för 25 år sedan. De ingår även som en mycket viktig del i hur celler kommunicerar med varandra. Det har de senaste åren visat sig vara kolhydrater inblandade i en mängd signalering- och igenkänningsmekanismer. Några exempel: när bakterier angriper en cell är det oftast Artificial, amfiphilic, and biomimetic receptors soluble in water were synthesized via attaching polar amino acids to hydrophobic back-bones possessing a surface suitable for hydrophobic interactions. The hydrophobic back-bones chosen in this thesis were anthracene and dibenzobarrelene structures. A route to an efficient synthesis of a dibenzobarrelene backbone with two sets of orthogonal reactivi
Temperature limitations of Solid Oxide Fuel Cells (SOFC) in transient single operation and steady-state Hybrid System (HS) operation with Gas Turbines (GT) are presented. For transient SOFC simulations, an unsteady-state SOFC model was developed by upgrading a detailed validated steady-state model. As critical SOFC single operation modes, concerning the risk of material cracking due to exceeding S
Popular Abstract in Swedish Allteftersom kraven på kvalité och prestanda hos dagens produkter ökar används alltmer avancerade material som en del av modern produktion. Problemet som uppstår är dock att dessa material ställer nya krav på tillverkningsprocessen och då inte minst vid skärande bearbetning. Trots att en betydande mängd forskning redan har publicerats vad gäller skärande bearbetning av As quality and performance demands on today’s products increases, more and more advanced materials are being used during modern production. The problem is however that this in turn place new demands on the machining processes utilized. Even though a significant amount of research has been published on the machining of these materials knowledge is still limited in several crucial areas. A problem w
This thesis investigates the impact of solar shading devices on energy use and daylight quality in office rooms. The impact on energy use is analysed through computer simulations with the dynamic energy simulation program Derob-LTH while the impact on daylight quality is investigated through measurements in full-scale experimental office rooms and simulations with the program Radiance. This thesis
AbstractThe uptake of different nitrogen forms by understory species was studied in field and laboratory. Species of the understory in deciduous forests have previously been thought to take up and assimilate only inorganic nitrogen sources. However, species also have the opportunity to assimilate amino acids, usually in low rates compared with ammonium, according to solution culture studies, but m
MOD17A2 provides operational gross primary production (GPP) data globally at 1 km spatial resolution and 8-day temporal resolution. MOD17A2 estimates GPP according to the light use efficiency (LUE) concept assuming a fixed maximum rate of carbon assimilation per unit photosynthetically active radiation absorbed by the vegetation (epsilon(max)). Minimum temperature and vapor pressure deficit derive
