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This master thesis has evaluated the possible use of a spray dryer to produce powders suitable for use as inhalants and whether the addition of liposomes to the solution to be spray dried would improve the properties of the powder. The powders created consisted of Lysozyme as model drug, Lactose as filler and stabilizer, and different types of phospholipids to create liposomes using an ethanol inj
When testing for means there are two classical assumptions to be considered, normality and equal variances (equal covariance matrices). Historically more attention seems to be directed towards violation of the assumption of equal variances, which is referred to as the Behrens-Fisher problem, than the assumption of normality. Our attention is equally directed to both the issues. We propose a bootst
Denna rapport redogör för design och utveckling av ett medicintekniskt instrument för diagnos av kronisk obstruktiv lungsjukdom (KOL) eller emfysem. Arbetet utgår ifrån en ny diagnosmetod och ett instrument i form av en funktionell prototyp som används för att testa den nya diagnosmetoden. Med utgångspunkt i den funktionella prototypen har arbetet fokuserats kring att förstå vilka problem och utmThis thesis presents design and development of a medical device for diagnosis of emphysema or COPD by controlled lung deposition of nanoparticles. After purging the lungs with particle free air the subject inhales a controlled aerosol mixture and holds his breath for a determined period of time, before exhaling. The degree of lung disease is calculated by measuring and comparing the concentration
This master thesis is about improving the accuracy of a Gantry-Tau robot by identifying the key parameters in the kinematics of the robot. This is done using a vision system and then estimating the parameters by minimizing the closure equation of the kinematics. The robot with improved control is then used for additive manufacturing. Furthermore, a prototype for a large plastic printer head is pre
The paper considers the solution of the boundary value problem (BVP) consisting of the Helmholtz equation in the region D with a rigid boundary condition on ∂D and its reformulation as a boundary integral equation (BIE), over an infinite cylindrical surface of arbitrary smooth cross-section. A boundary integral equation, which models three-dimensional acoustic scattering from an infinite rigid cyl
This paper reviews historical developments and recent challenges in full scale bridge testing and introduces results- and hypotheses related to an ongoing bridge testing research project. This research project encompasses full scale bridge testing in conjunction with bearing capacity analysis as well as related contact- and non-contact monitoring procedures combined with a decision analytical appr
The problem of finding maximum (or minimum) witnesses of the Boolean product of two Boolean matrices (MW for short) has a number of important applications, in particular the all-pairs lowest common ancestor (LCA) problem in directed acyclic graphs (dags). The best known upper time-bound on the MW problem for n× n Boolean matrices of the form O(n2.575) has not been substantially improved since 2006
We prove a mean field limit, a law of large numbers and a central limit theorem for a system of point vortices on the 2D torus at equilibrium with positive temperature. The point vortices are formal solutions of a class of equations generalising the Euler equations, and are also known in the literature as generalised inviscid SQG. The mean-field limit is a steady solution of the equations, the CLT
District heating and cooling systems have been undergoing continuous development and have now reached the fifth-generation. In this innovative technology, connected buildings share local excess energy that otherwise would be wasted, which consequently reduces primary energy demands and carbon emissions. To date, the issue of implementing fifth-generation district systems on existing buildings has
The current paper serves as the primary publication of a group of 30 dipinti (painted epigraphic documents), including 19 hieratic texts and 11 pictorial images or quarry marks. These were found and recorded within a series of quarries located on the east bank of Gebel el-Silsila. Recently excavated archaeological material places the creation of these quarries chronologically within the 18th dynasThe current paper serves as the primary publication of a group of 30 dipinti (painted epigraphic documents), including 19 hieratic texts and 11 pictorial images or quarry marks. These were found and recorded within a series of quarries located on the east bank of Gebel el-Silsila. Recently excavated archaeological material places the creation of these quarries chronologically within t
An experimental approach is described in which well-defined perturbations of the gas feed into an Ambient Pressure X-ray Photoelectron Spectroscopy (APXPS) cell are fully synchronized with the time-resolved x-ray photoelectron spectroscopy data acquisition. These experiments unlock new possibilities for investigating the properties of materials and chemical reactions mediated by their surfaces, su
Climate warming has caused the seasonal timing of many components of ecological food chains to advance. In the context of trophic interactions, the match–mismatch hypothesis postulates that differential shifts can lead to phenological asynchrony with negative impacts for consumers. However, at present there has been no consistent analysis of the links between temperature change, phenological async
A series of regioisomeric isosorbide mono-epoxides, as well as diastereomerically pure mono-epoxy derivatives, have been prepared and studied. Anionic ring-opening polymerization of methoxy-capped monomers produced linear polyethers tethered with isosorbide units. These reasonably high molecular weight polymers exhibited glass transition temperatures at around 10-15 °C and thermal stability up to
A recent study proposed by Westerlund (CCE in Panels with General Unknown Factors, Econometrics Journal, 21, 264-276, 2018) showed that a very popular Common Correlated Effects (CCE) estimator is significantly more applicable than it was thought before. Contrary to the usual stationarity assumption, common factors can in fact be much more general and not unit root only. This also helps to alleviat
A method of diagnosing a disease that includes obtaining experimental data on gene selections. The gene selection functions to characterize a cancer when the expression of that gene selection is compared to the identical selection from a noncancerous cell or a different type of cancer cell. The invention also includes a method of targeting at least one product of a gene that includes administratio
