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Phenotypic variance heterogeneity across genotypes at a single nucleotide polymorphism (SNP) may reflect underlying gene-environment (G×E) or gene-gene interactions. We modeled variance heterogeneity for blood lipids and BMI in up to 44,211 participants and investigated relationships between variance effects (Pv), G×E interaction effects (with smoking and physical activity), and marginal genetic e

Popular Abstract in Swedish Basala ganglierna ligger under hjärnbarken i hjärnan och består av grupper av nervceller som är förbundna med varandra och med hjärnbarken. Till dessa grupper av nervceller hör striatum, globus pallidus, subthalamicus-kärnan och substantia nigra. Patologiska förändringar i olika delar av basala ganglierna orsakar många av de symptom som kännetecknar Huntington's och ParHuntington's disease (HD) is a hereditary neurodegenerative disorder presenting with chorea, dementia and extensive striatal neuronal death. The mechanism through which the widely expressed mutant huntingtin mediates striatal neurotoxicity is unknown. Excitotoxicity, i.e. calcium-dependent cell death induced by activation of NMDA receptors, has been hypothesized to play an important role in HD. Ou

Methods for monitoring seepage and detecting internal erosion are essential for the safety evaluation of embankment dams. Internal erosion is one of the major reasons for embankment dam failures, and there are several tenths of thousands of large embankment dams in the world. Internal erosion is progressing inside the dam, and is sometimes difficult to detect by conventional methods. Therefore, th

Popular Abstract in Swedish "Det var en gång en kung som aldrig gjorde något bra för sina undersåtar. Han gjorde faktiskt aldrig nånting. Det enda han ville var att äta och dricka, och berusa sig tillsammans med sitt hov. Under tiden svalt folket ihjäl." Anna frågar: varför kunde inte människorna äta hemma? "Tyst nu, och lyssna på fortsättningen…" (citat ur avhandlingen) Martina Camparts forskniAbstract The point of departure for this study is the author's experience as educator in a residential home for children (age 6-14) with social-emotional problems, in Italy, between 1980 and 1989. One important element of the pedagogical approach was the use of narratives (personal, of others, of fiction) to prompt children's interest/ motivation to reflect about issues of personal concern. A conv

The most malignant brain tumour, glioblastoma multiforme (GBM), has an utterly bad prognosis. In spite of all available therapy, the mean survival time is less than a year. In the unique BRIGTT project (Brain Immuno Gene Tumour Therapy), patients at the Dept of Neurosurgery. Lund University Hospital, are immunised with their own glioma cells, which have been transfected with the immunostimulatory

The present work reports on the development of a bi-enzyme biosensor using diaphorase from Bacillus stearothermophilus, nicotinamide adenine dinucleotide (NAD(+))- and glutathione (GSH)-dependent formaldehyde dehydrogenase (FDH) from the genetically-engineered methylotrophic yeast Hansenula polymorpha as bio-recognition elements. The sensor architecture comprises a first layer containing diaphoras

In this conclusion we argue that, while we have demonstrated in this book that definitions of co-housing as well as co-housing practices in different European countries vary, there are some general lessons to be learned for anyone interested in understanding or practising co-housing in the context of advanced capitalist societies. This conclusion has three parts: First, we address the questions as

Purpose: To address the systematic bias in whole-brain dual flip angle (DFA) T1-mapping at7T by optimizing the flip angle pair and carefully selecting RF pulse shape and duration.Theory and Methods: Spoiled gradient echoes can be used to estimate whole-brain maps ofT1. This can be accomplished by using only two acquisitions with different flip angles, i.e., aDFA-based approach. Although DFA-based Purpose: To address the systematic bias in whole-brain dual flip angle (DFA) T1-mapping at 7T by optimizing the flip angle pair and carefully selecting RF pulse shape and duration. Theory and Methods: Spoiled gradient echoes can be used to estimate whole-brain maps of T1. This can be accomplished by using only two acquisitions with different flip angles, i.e., a DFA-based approach. Although DFA-ba

Anthropogenic land use and land cover changes (LULCC) have a large impact on the global terrestrial carbon sink, but this effect is not well characterized according to biogeographical region. Here, using state-of-the-art Earth observation data and a dynamic global vegetation model, we estimate the impact of LULCC on the contribution of biomes to the terrestrial carbon sink between 1992 and 2015. T

The polarization observables T,E,P,H, and G in photoproduction of η mesons off protons are measured for photon energies from threshold to W=2400 MeV (T), 2280 MeV (E), 1620 MeV (P,H), or 1820 MeV (G), covering nearly the full solid angle. The data are compared to predictions from the SAID, MAID, JüBo, and BnGa partial-wave analyses. A refit within the BnGa approach including further data yields pr

To investigate the Holocene vegetation history and shoreline displacement along the southeastern Swedish coast, two radiocarbon dated pollen, macrofossil and mineral magnetic sequences were studied in the western Blekinge coast: Hunnemara Lake and Smygen Bay. Both pollen records show mosaic vegetation with grasslands, heaths and woodlands prior to 11 300 cal. BP. Pinus-dominated mixed forest was i

Musculoskeletal conditions often manifest with the onset of pain and the resulting physical limitations. Musculoskeletal pain is almost inevitable in in individual's lifetime. It is one of the most common reasons for self-medication and entry into the health care system. Musculoskeletal pain affects in 4 adults and is the Most commons Source of serious long-term pain and physical disability. The M

A Holocene palaeomagnetic secular variation master curve (FENNOSTACK) and a relative palaeointensity curve (FENNORPIS) for Fennoscandia are presented. These curves were produced by stacking palaeomagnetic data obtained from six annually laminated (varved) lake sediment sequences and one non-laminated sediment sequence. The six independent varve chronologies were combined to form a timescale, which

Reactions of cis-[PtCl(NH3)(CyNH2)(OH2)](+) (Cy = cyclohexyl) with thione-containing single-stranded oligonucleotides d(T8XT8) and d(XT16) (X = I-s6 or U-s4) and the mononucleotides 4-thiouridine ((UMP)-U-s4) and 6-mercaptoinosine ((IMP)-I-s6) have been studied in aqueous solution at pH 4.1. The reaction kinetics was followed using HPLC methodology as a function of ionic strength in the interval 5

Thoracic cirripedes are sessile crustaceans that use six pairs of thoracic appendages (the cirri) to catch and handle food. We used scanning electron microscopy to examine the cirri, which include one to three pairs of maxillipeds in six species of thoracican barnacles, in search of correlations between cirral setation and feeding mode. The species studied comprise both pedunculate and sessile for

Background: While the association between increased maternal age and congenital disorders has long been recognized, the offspring of older fathers are also at increased risk of congenital disorders related to DNA errors during spermatogenesis. Recent studies have drawn attention to an association between increased paternal age and increased risk of schizophrenia. The aim of the current study was t