Search results

Moraxella catarrhalis is a human-specific commensal of the respiratory tract and an opportunistic pathogen. It is one of the leading cause of otitis media in children and of acute exacerbations in patients with chronic obstructive pulmonary disease, resulting in significant morbidity and economic burden. Vaccines and new immunotherapeutic strategies to treat this emerging pathogen are needed. Comp

Background – Advancing the development of highly efficacious and long-lasting malaria vaccines is hampered by incomplete knowledge of protective immune mechanisms and an absence of established correlates of immunity. Antibody avidity is frequently evaluated as an indicator of a high-quality or protective antibody response to vaccination. However, the importance of avidity in vaccine-induced immuni

This thesis is a study of the articles published in the Chinese newspaper 人民日报 Renmin Ribao, the People’s Daily, during the Great Chinese famine 1959-1961. The famine is considered to be the worst famine in the history of China and an estimated more than 30 million people died of starvation or illnesses brought about by starvation during these years. This thesis will be focusing on the articles pu

Patients with chronic liver impairment often display symptoms of affective psychiatric nature where the choice for antidepressant treatment is rational. Since caution is recommended when these drugs are used in such patients, a dose reduction is usually performed. We have previously reported that a dose reduction to liver-impaired portacaval shunted rats has resulted in similar brain concentration

This master thesis is a part of an inventory control research collaboration between NGIL (Next Generation Innovative Logistics) and Volvo Parts AB. Volvo Parts is a business unit within the Volvo Group that provides support and services for the aftermarket. Their objective is to maximise the uptime of Volvo Group products for the end users by providing support and ensuring availability of spare pa

The article examines the innovation-job quality-employment nexus in social and health care in the United Kingdom and Sweden, respectively. Through seven case studies carried out with a common methodological and analytical framework in the two countries, it shows how the constraining factors of fiscal strictures derived from budgetary regimes and chronic labor shortages have two key consequences foThe article examines the innovation-job quality-employment nexus in social and health care in the United Kingdom and Sweden, respectively. Through seven case studies carried out with a common methodological and analytical framework in the two countries, it shows how the constraining factors of fiscal strictures derived from budgetary regimes and chronic labor shortages have two key consequences fo

Despite the initial promise of immunotherapy for CNS disease, multiple recent clinical trials have failed. This may be due in part to characteristically low penetration of antibodies to cerebrospinal fluid (CSF) and brain parenchyma, resulting in poor target engagement. We here utilized transcranial macroscopic imaging to noninvasively evaluate in vivo delivery pathways of CSF fluorescent tracers.

The use of volatile anaesthetics has increased in situations where conventional anaesthetic machines are inadequate or unavailable, for example, cardiac surgery and intensive care. The disposable anaesthetic conserving device, AnaConDa (R), allows vaporization of liquid volatile anaesthetics from a syringe pump and rebreathing of exhaled anaesthetic. Clinical use requires understanding of device-s

Inhaled antibiotic treatment of cystic fibrosis-related bacterial biofilm infections is challenging because of the pathological environment of the lungs. Here, we present an "environment-adaptive" nanoparticle composed of a solid poly lactic-co-glycolic acid (PLGA) core and a mucus-inert, enzymatically cleavable shell of d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) for the site-specifi

Hematopoietic stem cells (HSCs) are of great importance for the body and can be used to treat diseases such as leukemia or autoimmune conditions. To be able to use HSCs more extensively in therapies we need to know more about how they are being regulated, one way to do this is by knocking down genes with RNA interference. In this project we test a new micro RNA (miRNA), called miR30E, to investiga

Background: Serially interconnected microfluidic devices enable advanced applications such as multi-step chemical processing and multi-organ-on-chip systems. However, managing these systems presents challenges due to interdependent fluid dynamics in their connecting channels, where even minor disturbances can propagate throughout the network, affecting overall system performance. Methods: This stu