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By use of a batch microcalorimeter of the thermopile type, heat production was measured in isolated populations of human peripheral blood cells exposed to defined immune complexes formed in vitro. It was found that most of the heat production recorded in whole blood after admixture of immune complexes occurs in the granulocytes. Under these conditions small but constantly higher activation values
Genom hela livet utgår all blodbildning från så kallade blodstamceller som försörjer kroppen med miljarder blodkroppar varje dag. En normal balanserad produktion av blodkroppar via blodstamcellerna är avgörande för att vi skall hålla oss friska. Störningar i denna balans kan få dramatiska konsekvenser, vilka bland annat inkluderar utveckling av anemi (”blodbrist”) och en ökad känslighet att drabbaDysfunctional blood cell development can have fatal consequences on human health, with implications for several key areas of modern medicine, including amongst others the broad research areas of oncology and immunology. The Division of Molecular Hematology (DMH) aims to generate new knowledge about the regulation of blood cell development by applying recent advances in stem cell technology, in ord
I ett samarbetsnätverk av svenska och internationella forskare är vår målsättning att mäta, individualisera och förbättra behandlingsresultat och hälsa hos personer med psykiska störningar. Vi fokuserar på patienternas egenbedömningar, utveckling av självskattningsskalor & applikationer samt kliniskt relevanta biologiska markörer. Ett projekt syftar till att undersöka effekten av livsstilsintervenIn a collaborative network of Swedish & international researchers, our aim is to measure, individualize and improve treatment outcomes and health in individuals with psychiatric disorders. We focus on patients' own assessments, the development of self-rating scales & applications, and clinically relevant biological markers. One project aims to investigate the effect of lifestyle intervention on me
In recent decades there has been an increasing demand in environmental sciences for harmonized climatic data at large spatial scales and long periods. Here we present easyclimate, a software package to obtain daily climatic data at high resolution (0.0083°, ∼1 km) with R. The package facilitates the downloading and processing of precipitation, minimum and maximum temperatures for Europe from 1950
Our research group on paediatric haematology is focused on bleeding- and coagulation disorders in children, in particular on haemophilia and venous thrombosis. Haemophilia A and B are hereditary, X chromosomal recessive bleeding disorders caused by deficiency or absence of coagulation factors VIII (FVIII) or IX (FIX) in the blood. The general aim of this part of the research program is to improve
Kliniskt centrum för hälsofrämjande vård integrerar forskning, undervisning och utbildning samt implementering och evaluering av klinisk hälsopromotion. Vår kliniska forskning är gränsöverskridande och syftar till att förbättra patientsäkerheten och hälsan på kort och lång sikt för den enskilda patienten och dennes familj, personalen, hälso- och sjukvården och samhället som stort. Våra aktiviteteThe Clinical Health Promotion Centre integrates research, teaching & training and implementation & evaluation of clinical health promotion. Our clinical research is cross-border and aims to improve patient safety and health benefits on short and long term of the individual patients and their family, the staff, the healthcare and society as a whole. The activities focus on improving prevention, t
Bacterial infections spanning from local wound infections, affecting patients with non-healing leg ulcers, postoperative wounds or burns, to severe infections and sepsis, are significant medical problems. Today's anti-infective treatments do not address the excessive activation of inflammatory pathways during infection and sepsis, and resistance problems are increasing. Hence, there is a huge unm
Atherosclerosis is a disease characterized by chronic inflammation and fibrosis of the intima of large and medium sized arteries. Atherosclerosis in the coronary arteries is the most common cause of myocardial infarction and atherosclerosis in the carotids and other major arteries supplying the brain is the major cause of stroke. Cardiovascular diseases caused by atherosclerosis is the most common
