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Aktivering av immunförsvaret dämpar den samme Kroppens immunförsvar består av en mängd olika typer av specialiserade celler, alla med sina unika egenskaper och nischer. För att immunförsvaret ska fungera så optimalt som möjligt krävs det att cellerna kan interagera och kommunisera med varandra, vilket görs med hjälp av proteiner som finns på cellernas yta. En typ av celler, som kallas CD8+ T cellAbstract 4-1BB (CD137/TNFRSF9) is a costimulatory receptor expressed by several cellular subsets of the immune system, but is commonly associated with CD8+ T cells. Stimulation of 4-1BB on CD8+ T cells with agonistic antibodies (α-4-1BB) causes a potent proliferation signal and an upregulated expression of CD11c. CD11c+CD8+ have previously been recognized to suppress other immune cells, such as F

The purpose of this work has been to perform numerical calculations on the cubical mixing tank the QB mixer, to be able to verify its strength and try to improve it. The QB mixer is produced by the company QB FoodTech AB. Firstly a CAD model was made from drawings of the mixer. Then the structure was analysed in aspects of pressure load, thermal loads and gravitational load. A modal analysis to ge

Besökarna kring Ivösjön har på senare år märkt av en förändring av vegetationen kring och i Ivösjön och därigenom en förändring av strandlinjens utformning. Sjön tycks allt mer växa igen av vass och flytbladsväxter, vilket tyder på en eutrofieringsprocess. I den här rapporten jämförs flygbilder från olika tidpunkter under en 70-års period fram till och med idag för att se om sjön verkligen har vuxThe visitors around Ivösjön have recently discovered observed a change in the vegetation around and into the lake and consequently a change in the formation of the shoreline. The lake appears to have been increasingly filled up by reed and floating leaf plants which points to an eutrophication process. In this report aerial photographs are compared from a period of 70 years up until today to disco

BACKGROUND--Continuous epithelial shedding and restitution processes may characterise the airways in diseases such as asthma. Epithelial restitution involves several humoral and cellular mechanisms that may potentially be affected by inhaled anti-asthma drugs. The present study examines the effect of a topical steroid on epithelial restitution in vivo in the guinea pig. METHODS--The airway epithel

Popular Abstract in Swedish Denna avhandling är en sammanläggningsavhandling som består av fyra artiklar inom arbetsmarknadsområdet. Den första artikeln behandlar en personalförstärkning till arbetsförmedlingen. Metoden har bestått i att jämföra tre arbetsförmedlingskontor som erhållit stora personalförstärkningar med tre kontor som inte fått någon personalförstärkning alls. Resultaten tyder på atThis thesis results from four research projects. The issues addressed in the projects are different types of labour market information problems. The purpose of the first article is to contribute to a better empirical under- standning of how an increase of staff at the Public Employment Service affects job seekers. In 1987, the Swedish Government decided to grant the Labour Market Administration ex

Time-varying signals, such as sound waves, low-frequency vibrations from the earth, or electrical impulses in the human body, are often non-stationary, meaning their characteristics change over time. Because of this, standard spectral analysis methods, which assume stationary signals, cannot be used for analyzing such signals, as they discard the time-varying dynamics. This necessitates methods fo

This thesis investigates the ignition and flame spread behaviour of engineered wood-based materials, focusing on Medium-Density Fibreboard (MDF), Particleboard, Oriented Strand Board (OSB), and Plywood. Thermal properties, such as thermal conductivity and specific heat capacity, were analysed using Transient Plane Source (TPS) measurements. A new technique has been introduced for measuring therma

Ever since the dawn of internet, a new wave of fast-growing software companies has emerged. The M&A scholars have struggled to find appropriate valuation mechanisms for unprofitable companies with ultra-high revenue growth. To overcome the uncertain future, a contractual provision called earnout is often used. An earnout is a contractual provision in a M&A-deal that states the seller of th

This scientific report has mainly studied the concept of Industry 4.0 and the possibility to send data from a temperature sensor to the cloud, a process which is an example of the term Internet of Things. The study has been conducted for the consultant business Rejlers to give the CEO as well as the Technical Manager a broader view of how they could implement IoT on behalf of costumers in the futu

The aim of the study was to investigate the relationships between job satisfaction and empathic concern, perspective-taking and performance-based self-esteem. The study did also aim to examine if empathic concern, perspective-taking and performance-based self-esteem could predict job satisfaction and investigate which one was the best predictor. The survey was answered by 232 working participants

With countries across the world finding pathways to counter CO2 emissions, sustainable mobility has become a critical topic for leaders, policymakers, and industries. The development of Battery Electric Vehicles (BEV’s) is seen as an important and effective way through which reliance on fossil fuels and thereby related CO2 emissions can be reduced. Statistics show that the number EV’s on the roads

With countries across the world finding pathways to counter CO2 emissions, sustainable mobility has become a critical topic for leaders, policymakers, and industries. The development of Battery Electric Vehicles (BEV’s) is seen as an important and effective way through which reliance on fossil fuels and thereby related CO2 emissions can be reduced. Statistics show that the number EV’s on the roads

Företagsobligationsmarknaden utgör en viktig del av Sveriges kapitalmarknad och har under de senaste åren upplevt en betydande tillväxt. Genom att emittera företagsobligationer har företag möjlighet att inbringa kapital till sin verksamhet, medan investerare erhåller avkastning. En nyckelaktör i denna process är arrangören, som utses av emittenten för att leda projektet. Arrangören spelar en avgörThe corporate bond market is an important part of Sweden's capital market and has experienced significant growth in recent years. By issuing corporate bonds, companies can raise capital for their operations, while investors receive a financial return. A key element in this process is the arranger, who is appointed by the issuer to manage the project. The arranger plays a crucial role, particul

Under början av 1900-talet var illegala aborter ett samhällsproblem i Sverige. Fosterfördrivning var straffbelagt, kvinnor som blivit ovilligt gravida stod därför inför valet att antingen föda barnet eller genomföra abort på egen hand. År 1939 trädde den första lagen på området, lagen om avbrytande av havandeskap, 1938 års lag, i kraft. Lagen tillämpades mycket restriktivt och antalet illegala aboIllegal abortions were a social issue in Sweden during the 20th century. Abortions were punishable, and therefore a woman who became pregnant against her will stood before the choice of either unwillingly giving birth or carrying out an abortion on her own. In 1939 the first law on abortions came into force. The law was restrictively interpreted and the number of illegal abortions continued to inc

I takt med den tekniska utvecklingen behandlas personuppgifter i allt större utsträckning och mer gränsöverskridande. Behandling och överföring av personuppgifter är förenat med en risk för att individens integritetsskydd åsidosätts. EU har en stark dataskyddslagstiftning och värnar om skydd av EU-medborgares personuppgifter. USA har inte en lika stark dataskyddslagstiftning. Samtidigt är USA en

Pappers- och pappersmassaindustrin har ökat markant under de senaste årtiondena. På grund av att samhället har blivit mer miljömedvetet har återvinning av papper blivit en allt viktigare del inom industrin. Återvunna pappersfiber är dock av lägre kvalité än nygjorda fibrer. Syftet med denna rapport är att analysera möjligheterna att använda ett enzym av typen lackas för att modifiera interaktionenThe pulp and paper industry have been a growing market during the last decades. Due to higher environmental concerns among people, the recycling of papers has become an even more important part of the industry. Recycled paper fibers however are of lower quality than virgin fibers. This report aims to analyze the possibility to use a laccase enzyme to modify the interaction between lignin and recyc

The drug discovery and development process has changed dramatically during the last decades and the growth of more efficient techniques as high throughput screening combined with combinatorial synthesis using amino acids and carboxylic acids on solid support makes it possible to investigate the affinity of molecules towards a biological target. Fragment based drug discovery (FBDD) has been impleme

In this project the aim was to design a concrete 3d printer. This report focuses on the extruder part of the printer and the printing material. The basic principle of 3d printing is that it is an additive manufacturing technique, on the contrary to the traditional subtractive manufacturing techniques. The potential benefits of concrete 3d printing compared to the techniques that are used today are

Unmanned ground vehicles (UGVs) operating in uneven and unstructured terrain are often limited by fixed sensor mounting, which can reduce mapping quality, situational awareness, and sensor performance when the vehicle body experiences pitch, roll, and vertical motion. This thesis presents the development of a compact four-degree-of-freedom (4-DOF) gimbal prototype for a terrain-mapping module on a