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Background: Neoadjuvant and/or adjuvant treatment has led to an improved survival in patients with resectable gastroesophageal adenocarcinoma (GEAC). Nevertheless, survival rates remain poor and, hence, there is a great need to identify novel treatment strategies and relevant complementary diagnostics. Immunotherapies targeting the PD‐1/PD‐L1 checkpoints have shown promising results, but simultane

Transitional care for adolescents with congenital malformations, such as anorectal malformations (ARM), is described sparsely in the literature and referred to as being inadequate. In order to organize future successful healthcare structures, knowledge of patient-reported important aspects of transition is required. The aim of the study was therefore to explore the needs and expectations of transi

According to a recent conjecture in the literature, earnings have become a poorer proxy for cash flow from operations over time. We find that since 1988, when cash flow statements started to be consistently reported in Compustat, the cash effectiveness of earnings has actually increased for a large sample of US manufacturing firms. This occurs despite the introduction of fair value accounting and

To increase the productivity in biopharmaceutical production, a natural step is to introduce integrated continuous biomanufacturing which leads to fewer buffer and storage tanks, smaller sizes of integrated unit operations, and full automation of the operation. The main contribution of this work is to illustrate a methodology for design and control of a downstream process based on integrated colum

The COVID-19 pandemic has disrupted scientific gatherings and conferences, opening up opportunities for virtual learning platforms. Realizing the potential of online academic exchanges, the World Psychiatric Association (WPA) also developed virtual avenues and information systems for capacity building of mental health professionals across the world. Among its first such initiatives, the WPA organi

We aimed to study the incidence, predictors, and outcome of chronic kidney disease (CKD) after heart transplantation (HT). All our HT patients 1988-2010 were considered for inclusion. Of these, 134 came for annual follow-ups including evaluation of glomerular filtration rate (GFR) using iohexol clearance measurements, and the CKD-EPI (adults) or Schwartz (children) formulae. Median GFR (Q1-Q3)(mL/

GABA is the major inhibitory neurotransmitter in the CNS and changes in GABAergic neurotransmission affect the overall activity of neuronal networks. The uptake of GABA into synaptic vesicles is mediated by the vesicular GABA transporter (VGAT), and changes in the expression of the transporter directly regulate neurotransmitter release. In this work we investigated the changes in VGAT protein leve

Background: Biomarkers serve as a quantitative measure of brain injury and may predict cognitive outcome after cardiac arrest. This study investigates the association and predictive accuracy of acute changes in Alzheimer disease-associated biomarkers to cognitive outcome in cardiac arrest survivors.Methods: Retrospective study of the Target Temperature Management after Out-of-Hospital cardiac arreBackground: Biomarkers serve as a quantitative measure of brain injury and may predict cognitive outcome after cardiac arrest. This study investigates the association and predictive accuracy of acute changes in Alzheimer disease-associated biomarkers to cognitive outcome in cardiac arrest survivors.Methods: Retrospective study of the Target Temperature Management after Out-of-Hospital cardiac arre

Research on development aid has focused on Western powers—the global South's 20th century colonial masters—largely ignoring the practices of donors who are not members of the West-dominated Organization for Economic Cooperation and Development and its Development Assistance Committee (DAC). This article informs about the world of "non-DAC donors," through examining Polish development aid and its s

This masters thesis presents a development of a software to analyse and evaluate a rotary mechatronic demonstration rig. Most of the hardware existed and the task was to develop software in Excel and PLC Ladder to detect dierences between the different setups in a mechatronic system. The software is supposed to be used for educational purposes on Tetra Pak and should thereby be easy to use and giv

The possibilities with monoclonal antibodies to be used as drugs against several diseases is of great interest to many pharmaceutical companies. However, efficient production is hindered by advanced and difficult purification steps in the downstream processing. Chromatographic systems have proven to be a powerful methodology promoting high purity, nevertheless associated with high costs. Therefore

To reach the global targets, a number of actions must be taken. Among other things, the EU has decided that the recovery rate for waste from the building sector shall be at least 70 weight percent by year 2020. This means that the building sector needs to take increased responsibility for its waste. Based on the global targets, the Swedish Parliament has formulated 16 environmental quality targets

Augmented Reality (AR) är på uppgång och många företag lägger miljontals dollar i branschen. Både Google och Apple har nyligen släppt sina egna AR SDK’er som kommer att köras på miljontals enheter inom en snar framtid. AR är verkligen fascinerande och har sagts vara nästa miljard-industri. Målet med denna avhandling är att undersöka vad som är möjligt med dagens AR för mobila enheter och undersökaAugmented Reality (AR) is on the rise and a lot of companies put millions of dollars into the industry. Both Google and Apple have recently released their own AR SDKs that will run on millions of devices in the near future. AR is really fascinating and have been said to be the next multi-billion-dollar industry. The goal of this thesis is to explore what is possible with today’s AR and what are th

The illegal downloading of copyrighted material digitally has existed ever since the internet's inception. At first this was ignored because it was a small enough problem but as the internet grew the amount of illegal file sharing grew with it. The practice of downloading illegal academic material is especially interesting to look at because there is a moral gray area where large publishers ea

Many theorists have argued that vision and geometry have been given too much precedence within architecture and architectural representation. This thesis uses feminist theory that criticizes the way that space and the future traditionally have been represented. It discusses how the tools that architects use to describe space and future, can affect the how they think. The starting point for the dis

Syftet med denna framställning är att genom en rättsdogmatisk och rättssociologisk metod begrunda och skapa en bättre förståelse för lagstiftarens val att särbehandla unga lagöverträdare. Med gällande rätt, dess historiska bakgrund, straffets funktion och myndighetsbegreppet i åtanke har särbehandlingen diskuterats i förhållande till begreppet rättvisa. Vid femton års ålder inträder straffansvar The purpose of this presentation is to create a better understanding of the Swedish legislation treating young offenders differently in comparison to adult offenders. With current legislation, its historical background, penalty function and the age of majority in mind, the differential treatment will be discussed in relation to the concept of justice. At the age of fifteen, the young individual be

This research paper focuses on historical, arithmetic equity market risk premium in emerging and frontier markets. Equity market risk premium, as we know it today, has been easily estimated in developed markets; whereas, emerging and frontier markets often require different approaches to determine an appropriate equity market risk premium. I make use of a variety of methods, including volatility a