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Background: Weused a sensitive and specific beta-site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1) assay to determine the relationship between BACE1 activity in cerebrospinal fluid (CSF) and markers of APP metabolism and axonal degeneration in early and late stages of Alzheimer disease (AD). Objective: To assess CSF BACE1 activity in AD. Design: Case-control and longitudinal follow-up
Concrete is the most common material used to build the structural framework in multistory buildings. However, the construction works carried out on the building site are affected by many different factors that may reduce productivity. Delayed material deliveries, poor planning and coordination of work tasks and production resources, as well as unfavorable weather are examples that reduce productiv
Purpose: The quantitative accuracy of Nuclear Medicine images, acquired for both planar and SPECT studies, is influenced by the isotope-collimator combination as well as image corrections incorporated in the iterative reconstruction process. These factors can be investigated and optimised using Monte Carlo simulations. This study aimed to evaluate SPECT quantification accuracy for 123I with both t
Background: Quantitative magnetic resonance imaging (MRI), e.g. relaxation parameter mapping, may be sensitive to structural and compositional tissue changes, and could potentially be used to non-invasively detect and monitor early meniscus degeneration related to knee osteoarthritis. Objective: To investigate MR relaxation times as potential biomarkers for meniscus degeneration through comparison
ABSTRACT: Neuroinflammation is implicated in the development and maintenance of persistent pain states, but there are limited data linking cerebrospinal fluid (CSF) inflammatory mediators with neurophysiological pain processes in humans. In a prospective observational study, CSF inflammatory mediators were compared between patients with osteoarthritis (OA) who were undergoing total hip arthroplast
Background: Many pathological processes can disrupt the integrity of the glomerular capillary wall and cause a massive leakage of protein, resulting in nephrotic syndrome (NS). Clinical parameters such as age, sex, renal function, presence of diabetes, and how NS is defined influence the spectrum of underlying diseases. In this study, we examine how these parameters interact.Methods: Age, sex, hem
BACKGROUND: Atraumatic localized convexity subarachnoid hemorrhage (cSAH) is an uncommon form of nonaneurysmal subarachnoid hemorrhage characterized by bleeding limited to the cerebral convexities. Ipsilateral cSAH can result from a variety of causes, such as internal carotid artery stenosis, obstruction, and dissection, although concomitant contralateral cSAH is exceptionally rare. In this case,
Adherence to antiretroviral therapy is a global problem among adolescents living with human immunodeficiency viruses (HIV), and it is associated with treatment failure and the development of viral resistance. One of the most significant barriers to treatment adherence among adolescents is forgetting to take drugs as prescribed. One of the key strategies recommended to improve this problem is the u
Background: The European Union's 7th Framework Programme (EU's FP7) project HEALS – Health and Environment-wide Associations based on Large Population Surveys – aims a refinement of the methodology to elucidate the human exposome. Human biomonitoring (HBM) provides a valuable tool for understanding the magnitude of human exposure from all pathways and sources. However, availability of specific bio
Course leaders in rehabilitation healthcare professionals’ higher education face challenges stemming from multi-disciplinarity and the co-existence of different stakeholders. So far, the literature mainly attributed to course leaders’ managerial tasks, neglecting other fundamental transversal skills. Students represent an essential source of information for understanding the expected characteristi
Background: Despite the proven efficacy of telestroke in improving clinical outcomes by providing access to specialized expertise and allowing rapid expert hyperacute stroke management and decision-making, detailed operational evidence is scarce, especially for less developed or lower income regions. Aim: We aimed to map the global telestroke landscape and characterize existing networks. Methods:
Populariteten för släktforskning har vuxit under dom senaste åren. Detta beror framför allt på att det blivit avsevärt enklare genom internets framfart. Idag kan privat personer bedriva släktforskning hemifrån då man tidigare behövde hjälp från arkivister och professionella släktforskare. Då stora mängder släktdata har digitaliserats och lagts ut på nätet genom olika internationella företag och idAssociation for computer aided genealogy research of Sweden(DIS) is investigating the possibility of a nationwide genealogical database (RGD) of Sweden's historical population. The finished database should contain basic information about individuals' names, birth, marriage, death, and individuals' relationships such as father, mother, husband/wife and children. This will make up a kind
Popular Abstract in Swedish Osteoporos (benskörhet) är ett tillstånd som definieras av låg benmassa och ett tillstånd som ökar med stigande ålder. Sjukdomen i sig är symptomfri men ökar risken för frakturer. Frakturer i kota, axel, handled, bäcken, och höft efter 50 års ålder är ofta förknippade med osteoporos och ca 70 000 sådana frakturer inträffar årligen i Sverige. Även artros (ledsvikt) i höfPartly due to an ageing population, the number of osteoporosis-related fractures and osteoarthritis (OA)-related hip and knee arthroplasty procedures is increasing. The individual suffering and the burden on society for these conditions is immense. Genetic contribution for the variance in bone mineral density (BMD) is estimated at around 60–80%, and for OA 50%, leaving a considerable proportion to
Abstract in Danish Amning har sundhedsmæssige fordele for mor og barn og mere udtalte fordele for præmature børn, men udenlandske undersøgelser viser, at færre præmature børn påbegynder amning, og færre præmature børn ammes i 4 og 6 måneder sammenlignet med mature børn. Der findes ikke danske undersøgelser om andelen af præmature børn, som påbegynder amning, men en dansk undersøgelse viser, at 60 Breastfeeding has even more pronounced health benefits for preterm infants than for full-term infants, but preterm infants are less breastfed. There is no consensus in Danish neonatal intensive care units (NICUs) about which clinical methods facilitate breastfeeding. Skin-to-skin contact between infant and parent is the first step in the breastfeeding process for preterm infants, but studies of to
The use of CFD-models as an engineering tool for fire based analytical design of buildings has increased over the last few years. The reason for this is partly that the legislation allows for analytical dimensioning but also because the legislation demands a high degree of verification for the analytical dimensioning. The biggest reason is, however, that the computer power has increased and reache
Background. Flecainide is a first-line rhythm control treatment for patients with atrial fibrillation (AF), however long-term treatment outcomes are understudied. Objective. To investigate associations of electro- (ECG) and echocardiographic indices with safety and efficacy outcomes of long-term flecainide treatment for recurrent AF. Methods. Consecutive patients with AF admitted for in-hospital f
About 4.4% of the global emissions of greenhouse gases can be ascribed to healthcare. Intensive care is among the most resource intensive specialties and the purpose of this study was to quantify the total climate impact of a Swedish intensive care unit (ICU) and identify modifiable elements that can lower the intensive care unit’s climate impact. A process-based life cycle assessment was conducte
This paper is a critique of an article in the Swedish magazine Filosofisk Tidskrift (Philosophical Magazine), in which professor Per Bauhn maintains that there is something wrong with having a group perspective in moral and political matters. In this article Bauhn makes three conclusions. The first one is that you violate Hume's law if you draw the conclusion that something is an oppression on
Popular Abstract in Swedish Blodet innehåller några av de mest grundläggande komponenterna för mänskligt liv. Med hjälp av hjärtats pumpkraft transporterar röda blodkroppar ut syre från lungorna till de mest avlägsna delarna av kroppen via gradvis tunnare blodkärl. Livshotande blödningar stoppas via blodplättarnas koagulerande förmåga och läkande egenskaper, medan de vita blodkropparna bekämpar inHematopoietic stem cells (HSCs) are defined by their capacity to self-renew and differentiate into all hematopoietic cell lineages. Postnatally, HSCs reside predominantly in the bone marrow and are relatively rare, but important cells because of their therapeutic potential in bone marrow transplantation protocols and in their involvement in the origin of certain leukemias. To study how various gen
