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The global methylation profile and the mutational status of 633 specific epigenetic regulators were analyzed in the pediatric tumor clear cell sarcoma of the kidney (CCSK). Methylation array analyses of 30 CCSKs revealed CCSK tumor DNA to be globally hypermethylated compared to Wilms tumor, normal fetal kidney, and adult kidney. The aberrant methylation pattern of CCSKs was associated with activat
Popular Abstract in Swedish Robotar är maskiner som rör sig efter hur man programmerar dem. I industriellt bruk monteras ofta ett verktyg på roboten så att den kan svetsa, gripa, slipa, borra eller göra andra saker. Det som gör roboten bra på detta är att den kan upprepa robot-programmet flera gånger när det har blivit skrivet. Detta gör att man kan programmera roboten en gång för en arbetsuppgiftAdvanced manufacturing technologies and programmable machines such as industrial robots are used to increase productivity and quality for competitiveness on a global market. Development of increasingly flexible manufacturing systems has resulted in an increasing importance of software aspects, both on a system level and for efficient interaction with human operators. Trends toward providing custom
Background: Current systemic therapies for metastatic pancreatic ductal adenocarcinoma are associated with poor outcomes with a 5-year overall survival rate under 5%. We aimed to assess the safety and antitumour activity of mitazalimab, a human CD40 agonistic IgG1 antibody, with modified FOLFIRINOX (mFOLFIRINOX; fluorouracil, leucovorin, oxaliplatin, and irinotecan), in chemotherapy-naive patients
Popular Abstract in Swedish Bröstcancer är den vanligaste cancerdiagnosen hos svenska kvinnor, ca 8000 tumörer diagnosticeras årligen. Vid rekommendation om behandling till patienter med nyupptäckt bröstcancer utgår man från ett antal prognostiska (risk för återfall och död utan behandling) och prediktiva (risk för återfall och död med specifik behandling) faktorer. Ålder, tumörstorlek, cancercellBreast cancer is a heterogeneous disease with variations in the biological profile and subsequent clinical prognosis. Molecular mechanisms for tumour progression are currently being explored in scientific settings, suggesting parallel evolution of tumour cells at primary and metastatic locations. The molecular profiles could be altered affecting individual patient’s treatment and prognosis. In the
Energy-saving glass is becoming very popular in building design due to their effective shielding of building interior against heat entering the building with infrared (IR) waves. This is obtained by depositing a thin layer of metallic-oxide on the glass surface using special sputtering processes. This layer attenuates IR waves and hence keeps buildings cooler in summer and warmer in winter. Howeve
The impact of cytogenetic findings in AML was analyzed in the large population-based Swedish AML registry. Karyotypic patterns differed by age: t(8;21), inv(16) and t(11q23) were more common in younger patients, whereas loss of 5q, 7q and 17p, monosomal karyotype (MK) and complex karyotype (CK) were more common in older patients. Patients with ≥5 chromosome abnormalities had worse overall survival
Popular Abstract in Danish Genterapi er en attraktiv terapiform mod neurologiske lidelser som Parkinsons sygdom og epilepsi af flere grunde. Gener med en terapeutisk effekt kan introduceres lokalt ved præcise injektioner i det syge væv, hvor genproduktet kan frigives fra nerveceller i respons til aktivitet i det omgivende væv. Ved genterapi omgås den forhindring som blod-hjernebarrieren udgør, ligGene therapy is an attractive strategy for neurological disorders, such as Parkinson’s disease and epilepsy, for several reasons. Introduction of genes with a therapeutic potential can be achieved locally, by accurate injections in the compromised tissue, and release of a transgene therapeutic substance can be regulated by the surrounding host neural circuitry. The gene therapy approach circumvent
The Natural gas Combined Cycle (NGCC) with post combustion capture using liquid solvents may in some cases be of interest to design with a flexible steam bottoming cycle, so that it can operate both with and without CO2 capture. It is then important that the choice of the low pressure (LP) steam turbine exhaust size is made accordingly. The paper describes why a flexible NGCC requires a LP steam t
The European Myeloma Network has organized two workshops on fluorescence in situ hybridization in multiple myeloma. The first aimed to identify specific indications and consensus technical approaches of current practice. A second workshop followed a quality control exercise in which 21 laboratories analyzed diagnostic cases of purified plasma cells for recurrent abnormalities. The summary report w
Five molybdenum oxide samples, subjected to conditions of oxidative ammonolysis and ammoxidation of toluene at 450 and 460°C, respectively, have been characterized using X-ray diffraction, scanning and transmission electron microscopy, and specific surface area measurements. In oxidative ammonolysis, the relatively large, freshly prepared MoO3 crystals are reduced to smaller MoO2 crystals with a c
Concussion is a frequent injury in many sports and is also common in para athletes. However, there is a paucity of concussion research related to para sport, and prior International Concussion in Sport (CIS) consensus papers have not substantively addressed this population. To remedy this and to improve concussion care provided to para athletes, the concussion in para sport (CIPS) multidisciplinar
AbstractEndocarditis, or heart valve infection, can be caused by a number of pathogens, many of which are Gram-positive bacteria. The diagnosis is based on imaging techniques such as echocardiography and on blood culture. The implementation of fast and accurate species identification methods, such as the matrix-assisted laser desorption/ionisation-time of flight mass spectrometry (MALDI-TOF MS) in
The EC Directive 2013/59/Euratom states in article 56 that exposures of target volumes in nuclear medicine treatments shall be individually planned and their delivery appropriately verified. The Directive also mentions that medical physics experts should always be appropriately involved in those treatments. Although it is obvious that, in nuclear medicine practice, every nuclear medicine physician
When doped into solid state transparent crystals, rare-earth ions can have optically excited states with milliseconds coherence time and up to six hours coherence time for hyperfine levels after being cooled down to liquid helium temperature. This long coherence property makes them unique as solid state material and attractive for quantum information applications.The rare-earth ions have narrow ho
Transport of people and freight on-road have a big impact on the total energy use in the world. The majority of these transports is propelled with diesel engines and the reason is simply that the diesel engine is better than the gasoline engine due to lower fuel consumption. But the cost of this is the increase in dangerous nitrogen oxides (NOx). Around 10 000 people dies everyyear due to emission
In the present study the time-course of DNA fragmentation following insulin-induced hypoglycemia was examined. In situ localization of DNA breaks were studied by the terminal deoxynucleotidyl transferase-mediated biotin- deoxyuridine triphosphate nick-end labelling method, and the temporal profile of DNA-fragmentation by agarose gel electrophoresis. Cell nuclei displayed terminal deoxynucleotidyl
Understanding how environmental variation influences even cryptic traits is important to clarify the roles of selection and developmental constraints in past evolutionary divergence and to predict future adaptation under environmental change. Female yellow dung flies (Scathophaga stercoraria) typically have three sperm storage compartments (3S), but occasionally four (4S). More spermathecae are th
Platform trials have become widely adopted across multiple disease areas over recent years, however, guidelines for operationalising these trials have not kept pace. We outline a series of documents that summarise the statistical components, and implicit processes, of the Staphylococcus aureus Network Adaptive Platform (SNAP) trial to provide an informal template for other researchers and reviewer
BACKGROUND: HYPO-RT-PC is a phase 3 trial comparing ultra-hypofractionated and conventionally fractionated radiotherapy in intermediate-to-high-risk localised prostate cancer. This 10-year update reports long-term efficacy and toxicity outcomes.METHODS: In this open-label, randomised, phase 3, non-inferiority trial done in ten centres in Sweden and two in Denmark, we recruited men aged 75 years or
