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Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes1,2 and molecular mechanisms that are often specific to cell type3,4. Here, to characterize the genetic contribution to these processes across ancestry groups, we aggregate genome-wide association study data from 2,535,601 individuals (39.7% not of European ancestry), including 428,452 cases
This study examines how public transport passengers experience and use travel time and under what conditions they are particularly concerned about shorter travel time. Using a survey of Swedish public transport users and a follow-up focus group, we compare current patterns with a similar 2009 study. Findings indicate a slight decline in perceived value of travel time, coinciding with a marked redu
Poly(styrene-b-vinylphosphonic acid) diblock copolymers have been prepared via sequential anionic polymerization and evaluated as nanostructured polymer electrolytes. The ionic block copolymers were synthesized by first initiating the polymerization of styrene using n-butyllithium in tetrahydrofuran at −78 °C. 1,1-Diphenylethylene was then added to the living polystyryl anions before charging diet
Popular Abstract in English “We are not free in this area.” This is what the iNduna, a traditional leader at KwaDapha, shared with me when we first met in August 2011. KwaDapha is a small rural community at Bhanga Nek, Kosi Bay, in northern KwaZulu-Natal/Maputaland – one of the most scenic areas on the South African coastline. Kosi Bay falls within the Coastal Forest Reserve section of the iSimaIn the past several decades under a growing influence of ecological modernisation, various assumed ‘win-win’ approaches to protected area conservation and poverty alleviation have been introduced all over the world, especially in resource-rich developing countries. Yet protected area conservation is an inherently political process, and the goals are often not achieved. There are concerns about com
Popular Abstract in Swedish Popularized summary in Swedish (Sammanfattning på svenska) Blödarsjuka - hemofili - är en ärftlig sjukdom som endast uppträder hos män och som överföres av kvinnliga bärare vilka ej är blödare. Sjukdomen tar sig uttryck i en abnorm blödningsbenägenhet med framför allt ledblödningar och då redan från tidig ålder. Det finns två typer av blödarsjuka, hemofili A respektiveIn patients with severe hemophilia it is today possible to prevent the development of arthropathy by giving effective continuous prophylaxis from an early age, thus preventing the VIII:C or IX:C concentration from falling below 1% of normal. All the signs show that if a high-dose prophylactic regimen - that is, 3,000-5,000 U/kg body weight annually - is started as early as 1-2 years of age, the pa
Proteinase 3 (PR3) is a neutrophil serine protease stored in the azurophil granules of the promyelocyte and its successors. The protease has been identified as an autoantigen for anti-neutrophil cytoplasmic autoantibodies (ANCA) occurring in patients with Wegener's granulomatosis. To characterize the biosynthesis and processing of human PR3 in a transgenic cellular model, cDNA encoding human pre-p
Liquefaction of human semen involves proteolytic degradation of the seminal coagulum and release of motile spermatozoa. Several members of human kallikrein-related peptidases (KLKs) have been implicated in semen liquefaction, functioning through highly regulated proteolytic cascades. Among these, KLK3 (also known as prostate-specific antigen) is the main executor enzyme responsible for processing
In cross-national studies, mean levels of self-reported phenomena are often not congruent with more objective criteria. One prominent explanation for such findings is that people make self-report judgements in relation to culture-specific standards (often called the reference group effect), thereby undermining the cross-cultural comparability of the judgements. We employed a simple method called a
A current focus of ecosystem services (ES) implementation is on the municipal level of government where international and national legislation and policies have to be translated into practice. Given this focus, an understanding of perceptions within municipalities of the ES concept is crucial to support the implementation process. Against this background, this paper examines the perceptions of Swe
Frostnedbrytning av betong kan få allvarliga konsekvenser för en konstruktions säkerhet, beständighet och funktionsduglighet eftersom betongens hållfasthet försämras. Frostskador uppstår vanligtvis i konstruktioner med hög fuktbelastning och som periodvis utsätts för frostangrepp. Olika typer av betongskador, vilka kan misstänkas vara frostrelaterade, har påträffats i svenska vattenkraftsanläggninFrost deterioration of concrete can result in severe consequences to the safety, durability and functionality of a structure since it impairs the strength of the concrete. Frost damage may occur to structures that are in contact with water and subjected to frost action. Different types of concrete damage, which are suspected to be frost related, have been observed in concrete structures in Swedish
The paper describes full-scale fire-fighting tests performed in an underground mine. A total of six different methods to fight a full scale fire in a mine tunnel were tested. The methods involved different fire-fighting equipment but were comparable regarding fundamental conditions such as length of response-route, fire-fighting set-up, and smoke and fire size. The aim was to compare different equ
The process of biogas upgrading with ionic liquids, i.e. pure 1-butyl-3-methylimidazolium bis(trifluoro-methylsulfonyl)imide ([bmim][Tf2N]), aqueous choline chloride/urea (ChCl/Urea), and aqueous 1-allyl-3-methyl imidazole formate ([Amim][HCOO]), was simulated in Aspen Plus and compared with the conventional water scrubbing upgrading technique. The comparisons of the performances on the amount of
Bo Cavefors Bokförlag AB (translated into English, this Swedish name would read Bo Cavefors Publishing Co. Ltd., to be abbreviated Cavefors below, when no confusion between the person and the company is likely to exist) was a Swedish publishing company, active between 1959 and 1982. During this period this company published about 620 books in several genres and with varying topical approaches. In
We present a detailed measurement of charged two-pion correlation functions in 0-30% centrality sNN=200 GeV Au+Au collisions by the PHENIX experiment at the Relativistic Heavy Ion Collider. The data are well described by Bose-Einstein correlation functions stemming from Lévy-stable source distributions. Using a fine transverse momentum binning, we extract the correlation strength parameter λ, the
The density of roots is an important factor influencing the rate and magnitude of landslides. Due to the increased variability in climate, mainly rainfall, Eastern Uganda is severely struck by an increasing number of these mass movements, often with human casualties as one of the negative impacts. The aim of this study is to explore the possibility to estimate the depth and density of the root sys
Introduction: There is increasing interest in implementing evidence-based integrated models of care in community-based mental health service systems. Assertive Community Treatment (ACT) is seen as an attractive, and at the same time challenging, model to implement in sectored service settings. This study investigates the implementation process of such an initiative.Methods: Interviews were conduct
A quite common view is that the scientific persona matters less in contemporary Western knowledge societies. Large research groups produce new scientific discoveries gathered around impersonal expert system. However, it is also well known that scientific cultures differ widely. In physics, the projects are quite impersonal, sometimes including thousands of persons. The prime example is the CERN or
