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BACKGROUND: In early breast cancer, variations in local treatment that substantially affect the risk of locoregional recurrence could also affect long-term breast cancer mortality. To examine this relationship, collaborative meta-analyses were undertaken, based on individual patient data, of the relevant randomised trials that began by 1995. METHODS: Information was available on 42,000 women in 78

In this study, design of low-order feedforward controllers from both reference signal and measurable disturbance for proportional–integral–derivative (PID) controllers is considered. The feedforward controllers from reference are equivalent to the use of a PID controller with set-point weighting. The design problem is formulated as a convex optimisation problem and then solved for a batch of proce

This paper contains a joint ESHG/ASHG position document with recommendations regarding responsible innovation in prenatal screening with non-invasive prenatal testing (NIPT). By virtue of its greater accuracy and safety with respect to prenatal screening for common autosomal aneuploidies, NIPT has the potential of helping the practice better achieve its aim of facilitating autonomous reproductive

Clinical and experimental results have revealed a fundamental role of calcitonin gene-related peptide (CGRP) in primary headaches. CGRP is widely expressed in neurons both in the central nervous system (CNS) and in peripheral sensory nerves. In the CNS there is a wide distribution of CGRP-containing neurons with the highest levels seen in striatum, amygdale and cerebellum. Moreover, in acute attac

Popular Abstract in Swedish Från början användes uttrycket "mannen i ledet" bara om meniga soldater, men det är också ett bildligt uttryck med innebörden gemene man, gräsrot, medlem på fältet/gräsrotsnivå/verkstadsgolvet. Den här avhandlingen handlar om unga män som under mitten av 1990-talet gjorde lumpen på ett pjäskompani vid Wendes artilleriregemente i skånska Hässleholm. ”Pjäs” betyder kanoneThis dissertation deals with young men who in the mid 1990s made their military service at a cannon company at Wende’s artillery regiment in the scanian town Hässleholm. ”Cannon” refers not only to cannons, but also to haubitses, grenade-throwers and other heavy arms. The focus, however, is on cultural and social aspects of everyday military service. What does actually happen in the encounter betw

The sensitivity of biosensors can be increased substantially by incorporation in a substrate recycling scheme. Based on the amplification of NAD+/NADH by the recycling reaction catalyzed by glycerol dehydrogenase (GDH) and diaphorase, NAD+/NADH can be determined amperometrically with around 1000 times higher sensitivity than for the substrate sensing mode. The sensitivity of enzyme electrodes were

Protein dynamics on the microsecond-millisecond time scales often play a critical role in biological function. NMR relaxation dispersion experiments are powerful approaches for investigating biologically relevant dynamics with site-specific resolution, as shown by a growing number of publications on enzyme catalysis, protein folding, ligand binding, and allostery. To date, the majority of studies

Popular Abstract in German Spannungsgesteuerte Kalziumkanäle haben eine große Bedeutung in vielen elektrisch erregbaren Zellen, wie z.B. in Nervenzellen und pankreatischen beta-Zellen. Hier werden sie folgendermaßen aktiviert: In der Nahrung enthaltener Traubenzucker (Glukose) wird nach einer Mahlzeit über den Blutstrom im Körper verteilt und in die beta-Zellen über Glukosetransporter aufgenommen.Voltage-gated Ca2+ channels are essential transducers of cellular signals in many electrically excitable cells. In the pancreatic beta-cell they mediate controlled Ca2+ influx, which is the final trigger for Ca2+ dependent release (exocytosis) of the blood glucose lowering hormone insulin. Several subtypes of voltage-gated Ca2+ channels are known and the L-type has been found to be the main contri

Since the mid 1960s sugar planters in Thailand have formed some of the strongest farmers associations in Asia. Organising practically all sugar planters, these associations have over the years successfully negotiated with sugar mill owners and with the state. They have achieved a system of revenue sharing in the cane and sugar industry which protects them from the vagaries of fluctuations in world

In clinical transplantation immunosuppressive agents are used in combination with the objective to achieve additive effects and less toxicity. A large number of novel drugs are candidates for clinical introduction at this time and experiments in animal models have an important role to play. The aim of this study was in brief to evaluate the capacity to inhibit the acute rejection process with biol

Popular Abstract in Swedish Avhandlingen omfattar tillverkning av metallmatris kompositer, MMC, baserade främst på aluminium legeringar. Nya metoder är utvecklade och undersökta där infiltrationen av fiberstrukturer av aluminiumoxid är stimulerad av mekaniska vågor vid frekvenser upp till 7 kHz. Vågrörelserna är genererade med nyutvecklad hög-magnetostriktiv aktuatorteknik. Målet med studierna harThe implementation of highly magnetostrictive wave-actuator techniques in preform infiltration processes for metal-matrix composite production is described. Metal matrix materials require additional methods to handle the content, shape and position of the ceramic reinforcements, which are not required for metal alloy casting. Commercial fabrication of advanced metal matrix composite products has

This paper reflects on the work done at a large UK university to redesign assessment procedures in a way that was intended to contribute to an improvement in assessment literacy for staff. Existing practice was reviewed and showed that changes in assessment processes were needed to make the organization of assessment more consistent and more transparent across the institution and to develop staff

Background: The SIOP-Renal Tumor Study Group (RTSG) does not advocate invasive procedures to determine histology before the start of therapy. This may induce misdiagnosis-based treatment initiation, but only for a relatively small percentage of approximately 10% of non-Wilms tumors (non-WTs). MRI could be useful for reducing misdiagnosis, but there is no global consensus on differentiating charact

This paper was prepared for a discussion of the concept of the schema, which is the fundamental pre-requisite for the presentation of experimental observations in natural language. On the basis of the schematism in language, the agent (knower) has been identified as the integrative component, which gives it the steering function in the behaviour on the visual cliff and the schematising processes a

Popular Abstract in Swedish Avhandlingen När tidningarna blev moderna – om svensk journalistik 1897-1969 syftar till att öka kunskapen om några av de fenomen som ingick i den svenska 1900-talsjournalistikens utveckling och expansion. Även om den svenska journalistiken naturligtvis moderniserades i olika steg, och flera av dem togs redan under 1800-talet, så infaller viktiga delar av denna modernisThe aim of the thesis is to increase the knowledge of some of the phenomena involved in the development and expansion of Swedish journalism in the 20th century. This is done primarily by research into the works of three major newspapermen, but also by studies of seven Swedish dailies’ reporting of nine labour market conflicts. The three newspapermen are C. G. Tengwall (chapter 1), Ewald Stomberg (

After several years of disussions, tests, investigations and additional tests, the suppliers and retailers within the Swedish business sector for food and commodities formed a jointly owned, non-profit company in 1997, which subsequently started in physical operations in 2000. This company, Svenska Retursystem AB (www.retursystem.se), is now responsible for introducing returnable transport packagi