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IGF-1 as a Drug for Preterm Infants : A Step-Wise Clinical Development

BACKGROUND: Insulin-like growth factor 1 (IGF-1) is a mitogenic hormone involved in many processes such as growth, metabolism, angiogenesis and differentiation. After very preterm birth, energy demands increase while maternal supplies of nutrients and other factors are lost and the infant may become dependent on parenteral nutrition for weeks. Low postnatal IGF-1 concentrations in preterm infants

Mirror, mirror on the wall, who's the innovator after all? : An explorative study of a management-initiated employee innovation process

Today, the innovation arena is open to a wider range of participants than previously acknowledged. One specifically neglected group of innovators in traditional innovation studies is non-R&D and non-managerial employees, also referred to as ‘ordinary’ employees by the existing body of literature on employee-driven innovation (EDI). These employees have no formal innovation function, meaning th

Evaluating the Effect of Minimizing Screws on Stabilization of Symphysis Mandibular Fracture by 3D Finite Element Analysis

Purpose: The objective of this work is to integrate structural optimization and reliability concepts into mini-plate fixation strategy used in symphysis mandibular fractures. The structural reliability levels are next estimated when considering a single failure mode and multiple failure modes. Patients and Methods: A 3-dimensional finite element model is developed in order to evaluate the ability

Quantum memory development and new slow light applications in rare-earth-ion-doped crystals

When doped into solid state transparent crystals, rare-earth ions can have optically excited states with milliseconds coherence time and up to six hours coherence time for hyperfine levels after being cooled down to liquid helium temperature. This long coherence property makes them unique as solid state material and attractive for quantum information applications.The rare-earth ions have narrow ho

Antibacterial and antioxidant double-layered nanofibrous mat promotes wound healing in diabetic rats

Diabetic wounds are problematic to heal owing to microbial infections as well as decreased proliferation and high concentrations of reactive oxygen species. In this study, a double-layered nanofibrous mat containing grape seed extract (GSE) and silver sulfadiazine (SSD) was fabricated. A synthetic biodegradable polymer, e.g., polycaprolactone (PCL), and a natural material (i.e., collagen) were emp

Riverine sources of bioreactive macroelements and their impact on bacterioplankton metabolism in a recipient boreal estuary

The loading of macroelements such as, dissolved organic carbon (DOC), totalnitrogen (N) and total phosphorus (P) from terrestrial soils to aquatic systems isincreasing in the northern hemisphere. This phenomenon has several ecologicaland biogeochemical consequences for inland and coastal water systems, which arelinked to bacterial cycling of DOC, N and P. During growth, bacteria assimilatemacroeleThe loading of terrestrially derived macroelements, such as dissolved organic carbon (DOC), total nitrogen (N), and total phosphorus (P), to inland and estuarine waters is increasing in the northern hemisphere. Thesemacroelements often limit heterotrophic bacterioplankton metabolism (production and respiration), which in turn influence food web structures, exchange of greenhouse gases between the

Multi-criteria Decision Analysis (MCDA) for Integrated Water Resources Management (IWRM) in the Lake Poopo Basin, Bolivia

Integrated Water Resources Management (IWRM) is a relatively new approach in Bolivia. However, it is now generally accepted that this approach needs to be established in order to find sustainable solutions for development and is actively promoted by the Water Ministry, especially in environmentally fragile regions, such as the Lake Poopo basin. The Lake Poopo basin is one of the poorest regions in

Excited State Processes in Solar Energy Materials

Popular Abstract in Swedish Den globala energianvändningen är idag större än någonsin. Faktum är att den, i takt med världens ständiga utveckling, kommer att fortsätta öka många år framöver. Sättet som energi har producerats på historiskt används dessutom i allra högsta grad fortfarande idag och innebär daglig förbränning av stora mängder organiskt material. Detta resulterar i en ökad koncentratioThis dissertation covers studies of excited state processes in two types of solar energy materials: alternating polyfluorene polymers and their blends with fullerenes in the active layer of plastic solar cells, and bis-tridentate RuII-polypyridyl complexes to be used as sensitizer in systems for artificial photosynthesis. The polymer:fullerene blends were studied by transient absorption and time-

rd1 Photoreceptor Degeneration: Photoreceptor Rescue and Role of Metalloproteases in Retinal Degeneration

The thesis is focused on an attempt to delay photoreceptor cell death in the rd1 mouse using Lens Epithelium Derived Growth Factor (LEDGF), Glutathione S-Transferase mu (GST-?? and Glutathione S-Transferase alpha (GST-?? in an organ culture paradigm as well as the role of metalloproteases (MMPs) and their tissue inhibitors in photoreceptor degeneration (TIMPs). The rd1 mouse model displays a reti

Spatiotemporal evolution of CO2 concentration, temperature, and wind field during stable nights at the Norunda forest site

Unusually high CO2 concentrations were frequently observed during stable nights in late summer 2006 at the CarboEurope-Integrated Project (CEIP) forest site in Norunda, Sweden. Mean CO2 concentrations in the layer below the height of the eddy-covariance measurement system at 30 m reached up to 500 mu mol mol(-1) and large vertical and horizontal gradients occurred, leading to very large advective

På spaning efter livets mening. Om livsfrågor och livsåskådning hos äldre grundskoleelever i en undervisningsmiljö som befrämjar kunskapande

Popular Abstract in Swedish Denna avhandling utgör den första delen i en planerad serie på tre rapporter med utgångspunkt i data insamlade läsåret 1993/94 i årskurs 9 vid en grundskola, där det lokala skolprojektet Tonåringens livssituation och livstolkning genomförts i ämnet religionskunskap. Det övergripande syftet med studien är att undersöka vilka centrala livsvärden eleverna ger uttryck för iThis dissertation makes up the first report based on data collected during the project "Teenagers: aspects of their life style and attitudes" (Tonåringens livssituation och livstolkning) in the subject Religious Studies taken by pupils attending Year 9 during the 1993/94 school year. The general aim of the study is to discover the central values of life which pupils hold, as expressed in an essay

A comprehensive, time-resolved SANS investigation of temperature-change-induced sponge-to-lamellar and lamellar-to-sponge phase transformations in comparison with 2H -NMR results

Time-resolved small-angle neutron scattering (TR-SANS) was employed to observe temperature-induced phase transitions from the sponge (L-3 to the lamellar ( L (alpha) phase, and vice versa, in the water-oil (n-decane)-non-ionic surfactant (C12E5 system using both bulk and film contrast. Samples of different bilayer volume fractions phi and solvent viscosities eta were investigated applying various

Conformational Entropies and Order Parameters: Convergence, Reproducibility, and Transferability

Conformational entropy provides major contributions to protein folding and functions, such as ligand binding, making it a potentially important driver of biologically relevant processes. NMR spectroscopy is a unique technique to estimate conformational entropy changes at atomic resolution, an approach that can be favorably augmented by comparisons with results from molecular dynamics (MD) simulati

I marknadens namn : mångtydiga reformer i svenska kommuner

This dissertation reports on a study of reform processes in public organisations. It describes how two municipalities planned and attempted the introduction of the purchaser-supplier model. This type of reform reflects one important contemporary idea - that of the market as an all-encompassing institution. The study focuses on the very process of reforming, with the aim of providing an alternative

BMP implants in bone formation. Studies in rabbits and rats

Popular Abstract in Swedish I ben finns tre olika sorters celler, osteoblaster, osteocyter och osteoklaster. Osteoblaster och osteocyter härstammar från stamceller som kallas stödjevävnadens stamceller och svarar för uppbyggnad och upprätthållande av benvävnaden medan osteoklasterna härstammar från de blodbildande stamcellerna och står för nedbrytning av ben. Ben är den enda vävnaden i kroppen somBone morphogenic proteins, BMPs, are a group endogenous proteins that are highly conserved through evolution. The amino acid sequences of about 15 different BMPs are now known and recombinant human BMPs are commercially available. Implantation of an individual BMP protein is sufficient to induce bone formation even at a subcutaneous site. Our initial studies discovered inhibition of bone formation

Structure and dynamics of highly concentrated LiTFSI/acetonitrile electrolytes

High salt concentration has been shown to induce increased electrochemical stability in organic solvent-based electrolytes. Accompanying the change in bulk properties is a structural ordering on mesoscopic length scales and changes in the ion transport mechanism have also been suggested. Here we investigate the local structure and dynamics in highly concentrated acetonitrile electrolytes as a func

Application Credit Transfer

Add title Page 1 of 4 APPLICATION FORM Application for credit transfer of courses at postgraduate level To be completed by the PhD student together with the main supervisor Name: Civic registration number: Email address: Main supervisor: To be able to process your application, the following documents need to be attached: • Course certificate (attested copy) • Course syllabus • Course schedule Info

https://www.intramed.lu.se/sites/intramed.lu.se/files/2025-06/Application%20credit%20transfer.pdf - 2026-05-03