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The development of Pt(IV) anticancer prodrugs to overcome the detrimental side effects of Pt(II)-based anticancer drugs is of current interest. The kinetics and reaction mechanisms of the reductive activation of the carboplatin Pt(IV) prodrug cis,trans-[Pt(cbdca)(NH3)2Cl2] (cbdca = cyclobutane-1,1-dicarboxylate) by the major small-molecule reductants in human plasma were analyzed in this work. The

This paper approach participation in visual promotional strategies as a novel form of public performance. The paper examines the social rules and conventions of photography practices on visual social media platforms in a qualitative study of how 30 participants in so-called Instagram takeovers make sense of and perform photography as an embodied visual practice situated in time and space.A dramatu

The total pancreatic lipolytic capacity was determined in duodenal contents in healthy humans 10-120 min after a liquid test meal, by estimating the amount of pancreatic lipase, colipase, carboxyl ester lipase, and phospholipase A2 by means of radioimmunoassays and enzymatic assays. The molar concentrations of the different proteins were of the same order of magnitude. The relative specific activi

Popular Abstract in Swedish Globala internationella standards har stort inflyttande i var nutida teknikorienterade värld. Exemplen är många: vi kan importera och exportera produkter och tjänster i de flesta andra länder, vi kan kommunicera med andra personer var de än befinner sig, vi kan även resa snabbt och effektivt. Men skapande och underhåll av internationella standarder är ingen enkel procesStandards are used everywhere in the modern world and are a fundamental part of a functioning society. But the creation and maintenance of international standards is not an easy task. In addition to the technical prerequisites that must exist to create a standard, there are also political, economic and cultural aspects that must be considered. The present thesis does not interpret all these aspec

Popular Abstract in Swedish Det mesta i min avhandling handlar om utveckling av uppreningsprocesser i läkemedelsindurstin. Den stora kostnaden för läkemedelsföretagen ligger oftast inte i att producera ett läkemedel, utan att ta fram en produkt. Det är också långt ifrån alla kandidater till läkemedel som till slut blir en produkt. Detta kan till exempel bero på att kandidaten inte var tillräckligtIn my thesis, I have modeled adsorption chromatography and simulated, calibrated, and analyzed models of adsorption chromatography. While my main focus has been modeling and calibration of the models by estimating the parameters, the models used have been partly new. The simulations are differentiated from the modeling in that the modeling describes the partial differential algebraic equation, whi

There is today a need of better prediction of part geometry regarding industrial products by simulations. There is a need for better prediction of material inflow, stresses and strains and final geometry. One way to solve this could be by using a more advanced friction model. Today a zero order friction model (Coulomb friction) is normally used. By using a friction model of higher order the fricti

Mutation testing is the state-of-the-art technique for assessing the fault detection capacity of a test suite. Unfortunately, a full mutation analysis is often prohibitively expensive. The CppCheck project for instance, demands a build time of 5.8 min and a test execution time of 17 s on our desktop computer. An unoptimised mutation analysis, for 55,000 generated mutants took 11.8 days in total, o

With the branding of a city as green increasingly serving to amplify attractiveness andinvestment while also contributing to patterns of green gentrification, the incentive to link real estate development and green space is growing. Yet, little is known about the extent to which this incentive has generated a spatial relationship between green space and newly constructed housing at the city-wide l

In order to keep up with the constant demand for higher data rates, the fifth generation of mobile communication (5G) introduced the use of mm-wave carrier frequencies from 24 to 71 GHz. Plenty of new frequency spectrum then became available, which has allowed for channel bandwidths of several hundreds of MHz. 6G is projected to continue this trend with even higher carrier frequencies and wider ba

The United Kingdom’s response to the pressing biodiversity decline in England includes the Biodiversity Net Gain (BNG) policy and is operationalised through DEFRA’s Biodiversity Metric, which quantifies biodiversity into ‘biodiversity units’. This thesis evaluates how effectively the metric reflects real biodiversity outcomes at the rewilded Knepp Estate in West Sussex. Using 2005 as a baseline an

Följande paper-presentation behandlar aspekter av ett doktorandprojekt i startgroparna. Hannes Wikströms musikpedagogiska studie faller under kategorin praktiknära forskning, i och med dess ambition att bidra till att stärka band och kontaktytor mellan forskningsmiljö och Kulturskolans pedagogiska praktik, samt dess vilja att låta skolpersonalens och elevernas röster, behov och frågeställningar tj

Aim. This observational study was undertaken in order to analyse whether any differences could be detected between diabetic and non-diabetic patients with critical limb ischemia (CLI) concerning the inflammatory response. Methods. A total number of 259 consecutive patients with CLI were treated between October 2001 and January 2003. Results. Among the 259 patients, 135 (52%) had diabetes, previous

To study the effects of the new vasodilating beta-blocking agent carvedilol on a variety of metabolic, hemodynamic, and ECG parameters of importance for the clinical outcome of acute myocardial infarction (AMI), we infused epinephrine (EPI) in healthy male volunteers on two separate occasions to serum concentrations of the same level reached in AMI. Before the EPI infusions, the volunteers were pr

Popular Abstract in Swedish Ett glas mjölk innehåller ungefär tusen miljarder små oljedroppar. Varje droppe är en tusendels millimeter stor. Dropparna är suspenderade i en blandning av vatten, proteiner och lösta molekyler. Små droppar av olja i vatten brukar kallas emulsioner. Emulsioner är vanliga beståndsdelar i livsmedel och finns exempelvis i allehanda mjölkprodukter, såser, smeter och dressiDifferent approaches and sub-models for the modelling of emulsification in a high-pressure homogenizer are reviewed and compared in terms of both practical aspects and how well they describe what is currently known on the emulsification process in general and on high-pressure homogenization in particular. Special effort is devoted to comparing the model developments presented in the appended paper

A novel rhodium(iii) complex [RhIII(H2LtBu)Cl3] (1) (H2LtBu = 2,6-bis(5-tert-butyl-1H-pyrazol-3-yl)pyridine) containing a pincer type, tridentate nitrogen-donor chelate system was synthesized. Single crystal X-ray structure analysis revealed that 1 crystallizes in the orthorhombic space group Pbcn with a = 20.7982(6), b = 10.8952(4), c = 10.9832(4) Å, V = 2488.80(15) Å3, and eight molecules in the

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https://www.staff.lu.se/sites/staff.lu.se/files/2025-12/386829_Lokalfo%CC%88rso%CC%88rjningsplan%202026_0.pdf - 2026-05-06