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Retinitis pigmentosa (RP), an inherited blinding disease, is caused by a variety of different mutations that affect retinal photoreceptor function and survival. So far there is neither effective treatment nor cure. We have previously shown that poly(ADP-ribose)polymerase (PARP) acts as a common and critical denominator of cell death in photoreceptors, qualifying it as a potential target for future

Context. The first data release from the Gaia mission contains accurate positions and magnitudes for more than a billion sources, and proper motions and parallaxes for the majority of the 2.5 million Hipparcos and Tycho-2 stars. Aims. We describe three essential elements of the initial data treatment leading to this catalogue: the image analysis, the construction of a source list, and the near rea

Optical measurement techniques have proven to be useful tools for studying combustion-related phenomenon. The fact that the techniques are optical facilitates performing the measurements without impinging upon the measurement object, such as the combustion event that can be involved. Such techniques can be species-specific and be performed in situ, i.e. in the setting in which the phenomena in que

Aim: The aim of this study is to evaluate the quality of data on endometrial (EC) and ovarian, fallopian tube, peritoneal, abdominal or pelvic cancers (OC) registered in the Swedish Quality Register of Gynecologic Cancer (SQRGC). Method: A random sample of 500 patients was identified in the SQRGC and their medical charts were reviewed for re-abstraction of 31 selected core variables by an independ

Inclusive jet production cross-sections are measured in proton-proton collisions at a centre-of-mass energy of s=8 TeV recorded by the ATLAS experiment at the Large Hadron Collider at CERN. The total integrated luminosity of the analysed data set amounts to 20.2 fb−1. Double-differential cross-sections are measured for jets defined by the anti-kt jet clustering algorithm with radius parameters of

The increased demand for high purity nanoparticles (NPs) of defined geometry necessitates the continuous development of generation routes. One of the most promising physical techniques for producing metal, semiconductor or alloy NPs in the gas phase is spark discharge NP generation. The technique has a great potential for up-scaling without altering the particles. Despite the simplicity of the set

Background: Mitochondrial diseases due to defective respiratory chain complex III (CIII) are relatively uncommon. The assembly of the eleven-subunit CIII is completed by the insertion of the Rieske iron-sulfur protein, a process for which BCS1L protein is indispensable. Mutations in the BCS1L gene constitute the most common diagnosed cause of CIII deficiency, and the phenotypic spectrum arising fr

BACKGROUND: The Eight-Twenty-One (ETO) nuclear co-repressor gene belongs to the ETO homologue family also containing Myeloid Translocation Gene on chromosome 16 (MTG16) and myeloid translocation Gene-Related protein 1 (MTGR1). By chromosomal translocations ETO and MTG16 become parts of fusion proteins characteristic of morphological variants of acute myeloid leukemia. Normal functions of ETO homol

A Lagrangian model of photochemistry and mixing is described (CiTTyCAT,stemming from the Cambridge Tropospheric Trajectory model of Chemistry AndTransport), which is suitable for transport and chemistry studies throughoutthe troposphere. Over the last five years, the model has been developed inparallel at several different institutions and here those developments havebeen incorporated into one "co

A method for determination of the accessible volume fraction in gels as function of the molecular weight of the solutes is presented. The pore-size distribution is determined by measuring the rate of diffusion of a mixture of solutes into a gel using gel filtration for separation. The solutes, of various sizes, are detected by refractive index measurements. Two marker molecules (blue dextran and g

Bark beetles face challenges and trade-offs during host selection, imposed by lethal tree defences, lower nutrition and higher competition in less well-defended trees, scarcity and ephemeral distribution of susceptible hosts, limitation of suitable hosts to one beetle generation, and relatively short lifespan and vulnerability of adults during host searching. Beetles contend with these challenges

Objectives. At the request of the European Commission and in the framework of the European Machinery Directive, research was conducted jointly in five different laboratories to develop specifications for surface temperature limit values for the gripping and handling of cold items. Methods. Four hundred and fourteen experiments were run where male and female subjects were invited to grip for up to

Popular Abstract in Swedish I mitt arbete som transplantationskoordinator på Kliniken för njurmedicin och transplantation på Universitetssjukhuset MAS i Malmö kommer jag i kontakt med många patienter som väntar på njurtransplantation. Det ingår i mitt arbete att informera dessa patienter inför uppsättning på väntelistan för njurtransplantation. En annan av mina arbetsuppgifter är att koordinera ocGreat efforts have been made to find solutions to the shortage of organs, such as extending the donor pool by accepting so-called marginal donors and development of transplantation of organs from animals (xenotransplantation, xt). Due to the scarcity of organs, there is a long tradition of prioritizing among patients on the waiting list for transplantation. Rules for allocation of organs have been

A processing scheme for the fabrication of embedded W-GaAs contacts has been established and the resulting contact characteristics have been evaluated. The main advantage of these contacts is that they are stable during high-temperature epitaxial overgrowth. The fabrication scheme is based on a liftoff process with electron beam evaporation of tungsten and subsequent epitaxial overgrowth using met

From the half-angle substitution of trigonometric terms in the Ernst equation, rational approximations of the flip angle dependence of the FLASH signal can be derived. Even the rational function of the lowest order was in good agreement with the experiment for flip angles up to 20°. Three-dimensional maps of the signal amplitude and longitudinal relaxation rates in human brain were obtained from e

The effect of reaction parameters on lipase-mediated chemo-enzymatic epoxidation of linoleic acid was investigated. Hydrogen peroxide was found to have the most significant effect on the reaction rate and degree of epoxidation. Excess of hydrogen peroxide with respect to the amount of double bonds was necessary in order to yield total conversion within a short time period, as well as at temperatur

Abstract in UndeterminedBackground: The long-term experience of living with peripheral arterial disease (PAD) and the durability of improvements after revascularisation are sparsely described in the literature. The primary goals of medical treatment and nursing care for PAD are to provide relief of symptoms, improve quality of life, and prevent the progression of arterial disease and cardiovascula