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OBJECTIVES: To investigate associations between a high genetic disease risk and disease severity in patients with systemic lupus erythematosus (SLE).METHODS: Patients with SLE (n=1001, discovery cohort and n=5524, replication cohort) and healthy controls (n=2802 and n=9859) were genotyped using a 200K Immunochip single nucleotide polymorphism array. A genetic risk score (GRS) was assigned to each
Atmospheric inverse modeling is a method for reconstructing historical fluxes of green-house gas between land and atmosphere, using observed atmospheric concentrations and an atmospheric tracer transport model. The small number of observed atmospheric concentrations in relation to the number of unknown flux components makes the inverse problem ill-conditioned, and assumptions on the fluxes are nee
Health education materials such as flipbooks enhance learning and deliver key messages in a captivating mode. Validation of such materials is crucial to ensuring implementation fidelity. We conducted a study to achieve two objectives: (a) to develop two flipbooks, one each for adolescents and young married women (YMW); (b) to validate the flipbooks using five parameters, namely, content validity,
In molecular neurobiology, perhaps no molecule has been as thoroughly examined as Alzheimer's beta-amyloid precursor protein (beta-APP). In the years since the cDNA encoding beta-APP was cloned, the protein has been the subject of unparalleled scrutiny on all levels. From molecular genetics and cellular biology to neuroanatomy and epidemiology, no scientific discipline has been left unexplored - a
In molecular neurobiology, perhaps no molecule has been as thoroughly examined as Alzheimer's beta-amyloid precursor protein (betaAPP). In the ten years since the cDNA encoding betaAPP was cloned, the protein has been the subject of unparalleled scrutiny on all levels. From molecular genetics and cellular biology to neuroanatomy and epidemiology, no scientific discipline has been left unexplored -
Background: Irritable bowel syndrome (IBS) is a common disease with unknown etiology. Poor dietary intake with nutritional deficiency and overweight have been described to increase the risk of IBS. The aim of the present study was to compare weight and circulating levels of micronutrients in IBS compared with healthy controls. Design: Cross-sectional study. Methods: Patients diagnosed with IBS and
Conventional measurements of fasting and postprandial blood glucose levels investigated in genome-wide association studies (GWAS) cannot capture the effects of DNA variability on ‘around the clock’ glucoregulatory processes. Here we show that GWAS meta-analysis of glucose measurements under nonstandardized conditions (random glucose (RG)) in 476,326 individuals of diverse ancestries and without di
Flexible and powerful control over network flows is one of the core advantages of Software-Defined Networking (SDN). Flow rules stored in switch network flow tables contain information on packet processing and routing. Flow rules are stored in memory, in a set of data structure rules, and managed by a classifier in flow tables. Network flows are a valuable asset: they contain information about the
Retinoic acid (RA) is an important morphogen that regulates many biological processes, including the development of the central nervous system (CNS). Its synthesis from vitamin A (retinol) occurs in two steps, with the second reaction - catalyzed by retinal dehydrogenases (RALDHs) - long considered to be crucial for tissue-specific RA production in the embryo. We have recently identified the Xenop
Recombinant DNA technology has made it possible to produce specific Fab and scFv antibody (Ab) fragments in prokaryotic host cells. Using vectors designed for periplasmic expression of encoded Ab fragments, we have been studying how the sequence and genetic localization of the light chain (L-chain) variable region gene of a mouse Ab (CB-Nm.1) determined the level of Ab production. The variable reg
The peer-reviewed literature presents overwhelming evidence that fossil fuel based energy infrastructure projects are responsible for lower residential property values, environmental destruction and pollution that decrease residents' quality of life. These projects also challenge local people's sense of identity and even the threat of such a project can make residents question their sense of place
Temporal genomic data hold great potential for studying evolutionary processes such as speciation. However, sampling across speciation events would, in many cases, require genomic time series that stretch well back into the Early Pleistocene subepoch. Although theoretical models suggest that DNA should survive on this timescale1, the oldest genomic data recovered so far are from a horse specimen d
An adaptive predictor for discrete time stochastic processes with constant but unknown parameters is described. The predictor which in real time tunes its parameters using the method of least squares is called a self-tuning predictor. The predictor has attractive asymptotic properties. If the parameter estimation converges and if the predictor contains parameters enough, then it will converge to t
1 Studenthandbok 2019/20 INSTITUTIONEN FÖR STRATEGISK KOMMUNIKATION 2 Välkommen! Strategisk kommunikation är ett flervetenskap- ligt ämne som hjälper oss att förstå, analysera och granska verksamhetskommunikation inom företag, offentliga organisationer och myndigheter utifrån ett holistiskt perspektiv. Kommunikation är grund- läggande i alla typer av arbeten. Förmågan att kom- municera väl blir al
https://www.isk.lu.se/sites/isk.lu.se/files/studenthandbok_2019_svenska.pdf - 2026-07-16
AI-Assisted and Semi-Autonomous tools are becoming relevant for enterprises. The adoption of these tools requires understanding how different practitioners perceive and use them responsibly in their organizations. This thesis examines how enterprise software development practitioners govern AI-assisted and semi-autonomous tools in everyday development workflows. As these tools increasingly support
Problems: A driving force for change in business is the availability of enterprise resource planning systems (ERP-systems). They have a great impact on companies, not only because they constitute exceptionally large investments, but also because they hold the promise of integrating companies more closely, hence, they should be important in the pursuit of synergy. In SCA Packaging, the landscape of
Helsingborg is currently (2018) conducting a city rejuvenation project in which it aims to densify and rejuvenate as well as increase the social status of the million programme neighbourhood Drottninghög. As Paul Stouten points out, neighbourhood rejuvenation can be used as a strategy to displace citizens with undesired social and economic status. The aim of this essay is to investigate if such hi
