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Recombinant DNA technology has made it possible to produce specific Fab and scFv antibody (Ab) fragments in prokaryotic host cells. Using vectors designed for periplasmic expression of encoded Ab fragments, we have been studying how the sequence and genetic localization of the light chain (L-chain) variable region gene of a mouse Ab (CB-Nm.1) determined the level of Ab production. The variable reg
The aim of this study was to evaluate the beta cell and incretin function in patients with HNF4A and HNF1A MODY during a test meal. Clinical characteristics and biochemical data (glucose, proinsulin, insulin, C-peptide, GLP-1 and GIP) during a test meal were compared between MODY patients from eight different families. BMI-matched T2D and healthy subjects were used as two separate control groups.
Associations are not random. Semantic memory is structured in a way that when hearing a category name a listener will automatically think of exemplars belonging to this category. The order in which exemplars come to mind and the frequency of retrieval of exemplars across individuals are measures of category-exemplar associative strength. Associative strength affects a broad range of psychological
Objective To study the risk of myocardial infarction (MI) in patients with atrial fibrillation (AF) treated in primary health care with warfarin or acetylsalicylic acid (ASA, aspirin). Methods The study population included subjects (n = 12,283) 45 years or older diagnosed with AF who were treated in 75 primary care centres in Sweden between 2001 and 2007. MI was defined as a hospital stay for MI d
Background: Diet has a great impact on the risk of developing features of metabolic syndrome (MetS), type 2 diabetes mellitus (T2DM), and cardiovascular diseases (CVD). We evaluated whether a long-term healthy Nordic diet (ND) can modify the expression of inflammation and lipid metabolism-related genes in peripheral blood mononuclear cells (PBMCs) during a 2-h oral glucose tolerance test (OGTT) in
Change Impact Analysis (CIA) during software evolution of safety-critical systems is a labor-intensive task. Several authors have proposed tool support for CIA, but very few tools were evaluated in industry. We present a case study on ImpRec, a recommendation System for Software Engineering (RSSE), tailored for CIA at a process automation company. ImpRec builds on assisted tracing, using informati
Wheat straw is one of the main agricultural residues of interest for bioethanol production. This work examines conversion of steam-pretreated wheat straw (using SO2 as a catalyst) in a hybrid process consisting of a short enzymatic prehydrolysis step and a subsequent simultaneous saccharification and fermentation (SSF) step with a xylose-fermenting strain of Saccharomyces cerevisiae. A successful
Under årens lopp har människan gjort stora landvinningar inom läkemedelsforskning, vilket har lett fram till avancerade läkemedel som idag tas för givna. Avancerade läkemedel sätter dock höga krav på tillverkarna av läkemedel, vilket har lett till att framtagandet av nya läkemedel är en ganska komplicerad process. Faktum är att dagens läkemedelsutveckling är så komplex att alla aspekter förmodligePopular Abstract in Swedish Under årens lopp har människan gjort stora landvinningar inom läkemedelsforskning, vilket har lett fram till avancerade läkemedel som idag tas för givna. Avancerade läkemedel sätter dock höga krav på tillverkarna av läkemedel, vilket har lett till att framtagandet av nya läkemedel är en ganska komplicerad process. Faktum är att dagens läkemedelsutveckling är så komplex
Objective. To study longterm work disability and possible predictors in newly diagnosed patients with primary Sjogren syndrome (pSS). Methods. Because we wanted to include only patients with full work availability potential, eligible patients were aged 18-62 years. Fifty-one patients (mean age 46 yrs, range 18-61 yrs, 50 women) diagnosed with pSS between January 2001 and December 2012 were include
Bioclimatic indices for use in studies of ecosystem function, species distribution, and vegetation dynamics under changing climate scenarios depend on estimates of surface fluxes and other quantities, such as radiation, evapotranspiration and soil moisture, for which direct observations are sparse. These quantities can be derived indirectly from meteorological variables, such as near-surface air t
Aims/hypothesis We aimed to investigate the risk of cancer mortality in relation to the glucose tolerance status classified according to the 2 h OGTT. Methods Data from 17 European population-based or occupational cohorts involved in the DECODE study comprising 26,460 men and 18,195 women aged 25-90 years were collaboratively analysed. The cohorts were recruited between 1966 and 2004 and followed
To ascertain the epigenomic features, i.e., the methylation, non-coding RNA, and gene expression patterns, associated with gain of i(12p) in Pallister-Killian syndrome (PKS), we investigated single cell clones, harboring either disomy 12 or tetrasomy 12p, from a patient with PKS. The i(12p)-positive cells displayed a characteristic expression and methylation signature. Of all the genes on 12p, 13%
The source contributions to carbonaceous PM2.5 aerosol were investigated at a European background site at the edge of the Po Valley, in Northern Italy, during the period January-December 2007. Carbonaceous aerosol was described as the sum of 8 source components: primary (1) and secondary (2) biomass burning organic carbon, biomass burning elemental carbon (3), primary (4) and secondary (5) fossil
Schema för MVEN21, 15 hp Kurstid: 2018-11-05 - 2019-01-20 Kursansvarig: Åsa Håkansson, asa.hakansson@food.lth.se Introduktion: Mån 5 nov 2018, sal Mossen Väster i Ekologihuset, kl 13.00. Lärare: BJ Birgit Josefson, info@kostutbildning.se CE Christer Eldh, Inst för service management och tjänstevetenskap, christer.eldh@ism.lu.se DJ Dan Johansson, Inst för livsmedelsteknik, LTH, dan.johansson@hbg.lt
https://www.cec.lu.se/sv/sites/cec.lu.se.sv/files/schema_2018_ny_version_181018.pdf - 2026-07-25
MILJÖVETENSKAP Preliminärt schema datum 181217 Kurs: MVEN11 Metodik och praktik Kursansvarig: Högni Hansson Lärare: HH Högni Hansson, hogni.hansson@cec.lu.se; JW John Winglander, John Winglander@infosoc.se; AB Anders Bengtsson, anders.bengtsson@dom.se; PE Patrik Edholm, patrik.edholm@sokigo.com; KM Kristoffer Mattisson, Kristoffer.Mattisson@med.lu.se; LL Leif Lövström, leif.loevstroem@fmh.se; SS S
https://www.cec.lu.se/sv/sites/cec.lu.se.sv/files/schema_mven11_metodik19.pdf - 2026-07-25
Schema för MVEN21, 15 hp Kurstid: 2018-11-05 - 2019-01-20 Kursansvarig: Åsa Håkansson, asa.hakansson@food.lth.se Introduktion: Mån 5 nov 2018, Ekologihuset, kl 9.00 Lärare: BJ Birgit Josefson, info@kostutbildning.se CE Christer Eldh, Inst för service management och tjänstevetenskap, christer.eldh@ism.lu.se DJ Dan Johansson, Inst för livsmedelsteknik, LTH, dan.johansson@hbg.lth.se GP Gunnel Persson
https://www.cec.lu.se/sv/sites/cec.lu.se.sv/files/schema_mven21_ht18_181007_0.pdf - 2026-07-25
PowerPoint Presentation Heat in Cities: Spatial and Social Dimensions David M. Hondula, PhD Assistant Research Professor Center for Policy Informatics & School of Geographical Sci. and Urban Planning Arizona State University Jennifer Vanos, PhD Assistant Professor of Atmospheric Sciences Department of Geosciences Climate Science Center Faculty Associate Texas Tech University Average Monthly High T
https://www.pi.lu.se/sites/pi.lu.se/files/heat-conference_2.pptx - 2026-07-25
Mental health disorders are a rapidly growing public health problem. Despite the fact that lack of trust in the health-care system is considered to be an important determinant of health, there is scarcity of empirical evidence demonstrating its associations with health outcomes. This is the first study which aims to evaluate the association between trust in the health-care system and psychological
Psykisk ohälsa är ett problem som har ökat i stor utsträckning de senaste åren och är idag en orsak till flertalet långtidssjukskrivningar i Sverige. Syftet med denna uppsats är att utreda hur långtgående arbetsgivarens rehabiliteringsansvar är då en arbetstagare drabbats av psykisk ohälsa, samt vilken möjlighet en arbetsgivare har att säga upp en sjuk arbetstagare. Rehabiliteringsansvaret har fåtMental illness is a problem that has grown extensively in recent years, and causes a majority of long-term sick leaves in Sweden. The purpose of this essay is to investigate how far-reaching the responsibility of the employers is for the rehabilitation efforts when an employee is suffering from mental disorder. The essay also examines the employers possibilities to dismiss a sick employee. The reh
The aim of this thesis is to map and explore how Swedish film archives work with archival intermediation and archival access activities, wherein the contemporary and transitional nature of film and film archives – from analogue to digital milieus – is considered. The intention is to deepen the knowledge concerning how these processes affect film archives as institutions of memory and film heritage
