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BspK, a serine protease from the predatory bacterium Bdellovibrio bacteriovorus with utility for analysis of therapeutic antibodies
The development of therapeutic and diagnostic antibodies is a rapidly growing field of research, being the fastest expanding group of products on the pharmaceutical market, and appropriate quality controls are crucial for their application. We have identified and characterized the serine protease termed BspK (Bdellovibrio serine protease K) from Bdellovibrio bacteriovorus and here show its activit
Genetic control of collagen-induced arthritis in a cross with NOD and C57Bl/10 mice is dependent on gene regions coding for complement factor 5 and FcγRIIb and is not associated with loci controlling diabetes.
The nonobese diabetic (NOD) mouse spontaneously develops autoimmune-mediated diseases such as diabetes and Sjögren′s syndrome. To investigate whether NOD genes also promote autoimmune-mediatedarthritis we established a NOD strain with an MHC class II fragment containing the Aq class II gene predisposing for collagen induced arthritis (NOD.Q). However, this mouse was resistant to arthritis in contr
Transformation and resilience in times of change: A historical perspective
Our current historical moment is marked by a widespread sense of (ongoing and anticipated) crises, prompting calls to change existing economic, political, social, and environmental systems. This discourse has directed increased scholarly and policy-orientated attention to the concepts of “transformation” and “resilience.” However,beyond attention, these concepts have increasingly adopted a place iOur current historical moment is marked by a widespread sense of (ongoing and anticipated) crises, prompting calls to change existing economic, political, social, and environmental systems. This discourse has directed increased scholarly and policy-orientated attention to the concepts of “transformation” and “resilience.” However, beyond attention, these concepts have increasingly adopted a place
New perspectives on complement mediated immunotherapy
Tumor-specific monoclonal antibodies (mAbs) offer several modes of tumor cell killing, from direct cytotoxic activity to indirect mechanisms employing the host immune system, particularly its innate branch. The latter effector functions seem to dominate among clinically approved anti-cancer mAbs and major efforts are being undertaken by both academia and the pharmaceutical industry with the aim to
Positional cloning of the Igl genes controlling rheumatoid factor production and allergic bronchitis in rats
Bacterial modulation of host glycosylation - in infection, biotechnology, and therapy
Popular Abstract in Swedish Hur gör bakterier för att komma undan immunförsvaret? Vi har studerat hur en vanligt förekommande bakterie, grupp A streptokocker, gör för att undvika kroppens immunförsvar vid infektion. Vi har upptäckt enzymer som bidrar till bakteriens förmåga att undvika immunförsvaret genom att avväpna antikroppar. De bakteriella enzymerna kan användas i bioteknisk industri och eveA majority of the proteins of the immune system are glycosylated and the glycans of IgG are essential for its functionality. Bacteria display enzymes that modulate the glycans of the immune system to weaken the host defense and favor bacterial survival. In this thesis we aimed at exploring bacterial modulation of host glycosylation in infection and to evaluate the usefulness of bacterial enzymes i
Immune complex binding Streptococcus pyogenes type M12/emm12 in experimental glomerulonephritis
Two major classes in the M protein family in group A streptococci
The M protein family of molecules in the group A streptococcus comprises a number of cell surface proteins that interact with the immune system of the host. One of the proteins in this family is the IgA receptor Arp4, which has C repeats similar to those that characterize the known M proteins. The streptococcal strain expressing Arp4 also expresses a second immunoglobulin-binding protein, Mrp4, wh
Investigation on the effects of fly ash particles on the thermal radiation in biomass fired boilers
Ash is produced in combustion of biomass. Sonic part of this matter is called fly ash and is carried by the flow and causes not only air pollution and erosion, but also call affect the thermal radiation. The effects of fly ash particles oil the thermal radiation are considered ill this investigation. By analyzing sampled data in all electrostatic filter, a realistic particle size distribution is f
Evasion of phagocytosis through cooperation between two ligand-binding regions in Streptococcus pyogenes M protein.
The M protein of Streptococcus pyogenes is a major bacterial virulence factor that confers resistance to phagocytosis. To analyze how M protein allows evasion of phagocytosis, we used the M22 protein, which has features typical of many M proteins and has two well-characterized regions binding human plasma proteins: the hypervariable NH2-terminal region binds C4b-binding protein (C4BP), which inhib
Derivation of efficiency factors for uneven irradiation on a fin absorber
In the equation for thermal energy output from a flat-plate solar collector (written as a function of the collector mean heat carrier temperature), both the gain and the loss terms are multiplied by the collector efficiency factor, F'. For a concentrating collector with an uneven (non-uniform) irradiation on the absorber, the efficiency factor for the gain term, here called the optical efficiency
Pi-gp.fd08poster
Poster Fechner Day 2008 Introduction Fechner (1801-1887) first discovered that when two stimuli are presented for comparison people systematically overestimate the magnitude of one stimulus and underestimate the magnitude of the other; termed, time-order effect (TOE) for stimuli separated by a time interval, and space-order effect (SOE) for stimuli separated spatially. Asymmetries in sensory discr
https://www.psy.lu.se/en/sites/psy.lu.se.en/files/pi-gp.fd08poster.pdf - 2026-05-07
Application For Credit Transfer 0
Date of arrival Document number Send your application to: counselling@sam.lu.se. Application for credit transfer for completed course or course module Name (first and last) Personal identity number Street address, postcode and city E-mail address Phone Programme Year of admission I hereby apply for a credit transfer and I wish to be exempted from taking the following course. For course module, ple
Internship summary
Susanne De Bourg 2016-11-06 NGEA51 – Internship course, 15 credits Autumn term 2016 Internship Summary – IKEA Group Sustainability During the autumn term 2016, I got the opportunity to have the internship course at IKEA in Malmö. During my stay at IKEA, I worked in “Group Sustainability”, closely linked with my supervisor Ivan, who works as a business analyst concerning sustainability issues. My p
https://www.nateko.lu.se/sv/sites/nateko.lu.se.sv/files/internship_summary.pdf - 2026-05-07
I fotbollens gränsland
Fotboll är ett fenomen med många fantastiska facetter. I första hand framträder utövarnas konstfulla kamp och publikens hänförelse. Den kommersiella karusell som vuxit fram kring själva spelet under senare decennier har därtill gjort fotbollen till en ekonomisk kraft.Fotbollen är en massrörelse utan modern motstycke och har därmed också blivit en resurs för den humanistiska och samhällsvetenskapli
https://www.cors.lu.se/publikationer/gastkronikor/i-fotbollens-gransland - 2026-05-07
Paul's Argumentation in Galatians : A Pragma-dialectical Analysis of Gal. 3.1–5.12
As one of the most important texts of the apostle Paul, Galatians offers a goodstarting-point for an investigation of Paul’s argumentation. The letter is polemical and contains a substantial amount of argumentative passages. Paul evidently wanted to persuade by using the best arguments possible to convince his addressees. Although the argumentation of Paul is often an issue within New Testament ex
Radio-telemetry observations of the first 650 km of the migration of Bar-tailed Godwits Limosa lapponica from the Wadden Sea to the Russian Arctic
In 1999 and 2000, 45 Bar-tailed Godwits Limosa lapponica were supplied with radio-transmitters during spring staging on the island Texel in the western Wadden Sea. With the use of Automatic Radio Tracking Stations (ARTS) on Texel and in south Sweden, and hand-held receivers on Texel, it was possible to follow the later part of the stopover period on Texel for 34 birds (76%) and the passage over so
Oxygen and its impact on nitrification rates in aquatic sediments
Eutrofiering det oönskade fenomenet av hög näringstillförsel i ett akvatiskt system, är för det mesta ett resultat av mänsklig påverkan: industriellt och urbant avloppsvatten, avrinning av gödningsmedel från odlad mark, och förbränning av fossila bränslen. Studien av de främsta faktorerna som bidrar till eutrofiering (t. ex. variationer i kvävets kretslopp), är viktigt för förståelsen av dess negaEutrophication, the undesired phenomenon of high nutrient loads in an aquatic system, is mostly caused by human impact: industrial and urban waste water discharge, run-off of fertilizers from agricultural use, and combustion of fuels. The study of eutrophications' main participants such as the nitrogen cycle, are necessary to prevent it. Environmental parameters have an impact onto the effecti
