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A major challenge in the development of peptide-based vaccines is finding the right immunogenic element, with efficient and long-lasting immunization effects, from large potential targets encoded by pathogen genomes. Computer models are convenient tools for scanning pathogen genomes to preselect candidate immunogenic peptides for experimental validation. Current methods predict many false positive
Objective To avoid negative effects of drug treatment and need for additional medical care, drug treatment must be individualised. Our research group has developed a model for clinical pharmacy which improves several aspects of the patient's drug treatment. This study describes the process behind these improvements, i.e. drug related problems identified by pharmacists within a clinical pharmacy se
In ethanol production from lignocellulose by enzymatic hydrolysis and fermentation, it is desirable to minimize addition of fresh-water and waste-water streams, which leads to an accumulation of substances in the process. This study shows that the amount of fresh water used and the amount of waste water thereby produced in the production of fuel ethanol from softwood, can be reduced to a large ext
A crucial debate is under way concerning the public's participation in biotechnology decision-making processes. This study, concerning the policy process around xenotransplantation (XTP) in Latvia and Sweden in the period 1970-2004, focuses on how scientific experts and politicians view the public and the public's participation in the process of developing policy regarding XTP. Drawing on intervie
This paper investigates the heterogeneity of the sources of external knowledge and their differentiated effects on process and product innovations respectively. The results of the empirical investigations show that the upstream vertical sources of external knowledge from suppliers exert a strong and positive role on the introduction of process innovations, whereas horizontal and downstream vertica
The broad aim of this thesis is to explain the fundamental themes and function of Swedish field sermons and field prayers, and so to re-examine the view in earlier research that field sermons were primarily ‘Old Testamentary’ in nature. Inspired by more recent international research, I hold that the sermons’ basic functions were twofold: discipline and comfort. What matters, is to understand the d
Background: There is currently a steady increase in the use of wood-based fuels for heat and power production in Sweden. A major proportion of these fuels could serve as feedstock for ethanol production. In this study various options for the utilization of the solid residue formed during ethanol production from spruce, such as the production of pellets, electricity and heat for district heating, w
An optimization study of an integrated periodic counter-current chromatography (PCC) process in a monoclonal antibody (mAb) downstream process at lab scale, is presented in this paper. The optimization was based on a mechanistic model of the breakthrough curve in the protein-A capture step. Productivity and resin utilization were the objective functions, while yield during the loading of the captu
This study investigates and challenges the capability of standard and hybrid soft computing models of fuzzy c-means clustering adaptive neuro-fuzzy inference system (ANFIS), wavenet and artificial neural networks (MLPNN and RBFNN) to estimate the spillway aerator air demand in dams. For the learning process, four different meta-heuristic op
Many cities have set ambitious goals regarding the production of renewables within cities using advanced energy planning. The crux of those ambitious plans and goals is to put them into action using different legislative instruments, like a zoning plan. In this article, the experiences of an action research project with the aim to support local urban planners developing a zoning plan that creates
Charged Higgs boson production in association with a top quark could be the first indication of the existence of Higgs particles. The Tevatron Run-II started data-taking in April 2001 at √s = 1960 GeV and could probe the existence of a charged Higgs boson beyond the current mass limit. We study the pp̄ → tbH± production process with Monte Carlo simulations in HERWIG and PYTHIA, comparing expected
The aim of the study was to explore inter-rater reliability and rater experiences of applying the universal instrument Assessment of Learning Process (ALP) with persons with profound intellectual and multiple disabilities. The study used a mixed-methods design. Inter-rater reliability was tested by eight clinical raters who assessed 23 video clips of people learning to use a powered AKKA mobility
