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27 January 2022

From the Management The first Swedish Climate Symposium! CEC are proud and happy to inform you that the first Swedish Climate Symposium, arranged by BECC, MERGE, SMHI and Bolins Center, will take place in Norrköping 15-18 May. Invitation is attached! Abstract submissions (talk or poster): no later than 15 February. Registration: no later than 15 March. The event will gather leading Swedish climate

https://www.cec.lu.se/staff-pages/staff-newsletters/27-january-2022 - 2026-05-29

Ulf Ryde

Professor Contact details Email: ulf [dot] ryde [at] chem [dot] lu [dot] se Phone: +46 46 222 45 02 Mobile: +46 73 065 53 57Organisation Computational Chemistry Service point: 1 WebpageUlf Rydes profile in Lund University research portalOther affiliations Member of Strategic Research Area eSSENCE: The e-Science CollaborationResearch areasBiochemical molecules studied by theoretical methods.The rel

https://www.compchem.lu.se/ulf-ryde - 2026-05-29

Deglaciation history and subsequent lake dynamics in the Siljan region, south-central Sweden, based on new LiDAR evidence and sediment records

The Siljan region hosts Europe´s largest impact structure. The high-relief landscape, with a central granite dome bordered by lake basins, contains an array of glacial and shore-level landforms. We investigated its deglaciation history by mapping and analysing landforms on high resolution LiDAR-based Digital Surface Models coupled with well-dated sediment successions from peat and lake sediment coThe Siljan region hosts Europe´s largest impact structure. The high-relief landscape, with a central granite dome bordered by lake basins, contains an array of glacial and shore-level landforms. We investigated its deglaciation history by mapping and analysing landforms on high resolution LiDAR-based Digital Surface Models coupled with well-dated sediment successions from peat and lake sediment co

Phase II trial demonstrates the efficacy and safety of individualized, dosimetry-based 177Lu-DOTATATE treatment of NET patients

Purpose: Radionuclide therapy with 177Lu-DOTATATE is well established for patients with advanced somatostatin receptor–positive neuroendocrine tumors with a standard schedule of 7.4 GBq at four occasions. However, this approach does not consider individual variability affecting the tumor radiation dose or dose to organs at risk. Therefore, it is important to assess more personalized strategies. Th

Primary Retroperitoneal Lymph Node Dissection as Treatment for Low-volume Metastatic Seminoma in a Population-based Cohort : The Swedish Norwegian Testicular Cancer Group Experience

Background and objective: There is an unmet need to avoid long-term morbidity associated with standard cytotoxic treatment for low-volume metastatic seminoma. Our aim was to assess the oncological efficacy and surgical safety of retroperitoneal lymph node dissection (RPLND) as treatment in a population-based cohort of metastatic seminoma patients with limited retroperitoneal lymphadenopathy. Metho

Patterns and determinants of shorebird species richness in the circumpolar Arctic

Aim The intention with this study was first to investigate and describe the broad-scale geographical patterns of species richness of breeding shorebirds (Charadriiformes; families: Charadriidae, Scolopacidae and Haematopodidae) throughout the arctic tundra biome. Secondly, after compensating for the positive relationship between net primary productivity (NPP) and species richness, the relative imp

Iec contribution list 26 june

Contribution list_prel International Eclogite Conference 20-29 August 2017 Preliminary contribution list SHORT VERSION 2017-06-26 Total 124 contributions: 10 keynotes 49 ordinary orals (43% of ordinary presentations) 65 posters (57% of ordinary presentations) The Scandinavian Caledonides – the importance of eclogites Responsibility: Jaroslaw Majka, Marian Janák, and David Gee 2 keynotes + 7 orals

https://www.geology.lu.se/sites/geology.lu.se/files/iec_contribution_list_26_june.pdf - 2026-05-30

NGEN01 Course Evaluation 2021

NGEN01_HT2021_rapport NGEN01_HT2021 Course Evaluation Answer Count: 5 Part I: Your thoughts on the course in general (If not indicated in another way: 1= not at all, 5=very well) Do you think that the aims, as described above, have been  achieved in this course? Do you think that the aims, as  described above, have been  achieved in this course? Number of responses 1 0 (0,0%) 2 0 (0,0%) 3 0 (0,0%)

https://www.nateko.lu.se/sites/nateko.lu.se/files/2023-04/NGEN01%20course%20evaluation%202021.pdf - 2026-05-30

Effects of indigestible carbohydrates in barley on glucose metabolism, appetite and voluntary food intake over 16 h in healthy adults

Background: Recent knowledge in animals suggests that gut microbial metabolism may affect host metabolism, including appetite regulating hormones. The aim of the present study was to evaluate the potential effects of a whole grain barley kernel product, rich in intrinsic indigestible carbohydrates (dietary fibre and resistant starch), on markers of metabolism and appetite regulation in healthy sub

Development of sensitive cellular assay systems and their application to the identification of "orphan" seven-transmembrane receptors

Popular Abstract in Swedish I alla flercelliga organismer behövs utbyte av information mellan cellerna, som bygger upp kroppen. För detta ändamål är cellerna försedda med små antenner, som kan ta emot signaler och kallas därför receptorer. Receptorer kan vara uppbyggda på olika sätt. De flesta receptorer slingrar sig sju gånger genom membranet och har ett gemensamt sätt att fortleda signaler till Seven-transmembrane, G-protein coupled receptors play a central role in physiology since they facilitate cell communication in multicellular organisms by recognition of a broad range of ligands. They also represent important drug targets. Unfortunately, for many of these receptors the endogenous ligands, and, hence, their physiological functions, remain to be identified. These receptors are usuall

Methotrexate, Doxorubicin, and Cisplatin (MAP) Plus Maintenance Pegylated Interferon Alfa-2b Versus MAP Alone in Patients With Resectable High-Grade Osteosarcoma and Good Histologic Response to Preoperative MAP: First Results of the EURAMOS-1 Good Response Randomized Controlled Trial

Purpose EURAMOS-1, an international randomized controlled trial, investigated maintenance therapy with pegylated interferon alfa-2b (IFN-α-2b) in patients whose osteosarcoma showed good histologic response (good response) to induction chemotherapy. Patients and Methods At diagnosis, patients age ≤ 40 years with resectable high-grade osteosarcoma were registered. Eligibility after surgery for good

Sleep disturbance in association with elevated pulse rate for prediction of mortality--consequences of mental strain?

OBJECTIVES: Sleep deprivation has experimentally been shown to adversely influence glucose metabolism, endocrine function and sympathovagal balance in young men without known serious disease. We investigated the impact of sleep problems and resting heart rate in a large sample of self-reported, healthy middle-aged men and women on long-term mortality. METHODS: In all 22,444 men and 10,902 women pa

Right atrial free wall conduction velocity and degree of anisotropy in patients with stable sinus rhythm studied during open heart surgery

AIMS: Although the perpetuation of several supraventricular arrhythmias is critically dependent upon intra-atrial conduction, the literature lacks detailed information on normal values of conduction velocity and degree of anisotropy. In order to explore these factors further, we have measured conduction velocities at the right atrial free wall during sinus rhythm and during atrial pacing in four d

Gastrin and the neuropeptide PACAP evoke secretion from rat stomach histamine-containing (ECL) cells by stimulating influx of Ca2+ through different Ca2+ channels

Gastrin and PACAP stimulate secretion of histamine and pancreastatin from isolated rat stomach ECL cells. We have examined whether or not secretion depends on the free cytosolic Ca2+ concentration ([Ca2+i) and the pathways by which gastrin and PACAP elevate [Ca2+i. Secretion was monitored by radioimmunoassay of pancreastatin and changes in [Ca2+i by video imaging. The patch clamp technique was use

Probing the activation of protein C by the thrombin-thrombomodulin complex using structural analysis, site-directed mutagenesis, and computer modeling

Protein C (PC) is activated to an essential anticoagulant enzyme (activated PC or APC) by thrombin (T) bound to thrombomodulin (TM), a membrane receptor present on the surface of endothelial cells. The understanding of this complex biological system is in part limited due to the lack of integration of experimental and structural data. In the work presented here, we analyze the PC-T-TM pathway in t

Characterization of the interleukin-17 effect on articular cartilage in a translational model : An explorative study

Background: Osteoarthritis (OA) is a progressive, chronic disease characterized by articular cartilage destruction. The pro-inflammatory cytokine IL-17 levels have been reported elevated in serum and synovial fluid of OA patients and correlated with increased cartilage defects and bone remodeling. The aim of this study was to characterize an IL-17-mediated articular cartilage degradation ex-vivo m

Survival patterns after perioperative treatment escalation and cystectomy for synchronous oligometastatic bladder cancer (M1a/M1b) – a population-based series

Background: The role of cystectomy in synchronous oligometastatic bladder cancer is unclear. Objective: To describe a population-based consecutive cohort with primary oligometastatic bladder cancer (M1a or M1b) treated with curative intent. Methods: Twenty consecutive patients with primary stage M1a or M1b bladder cancer subjected to induction chemotherapy and radical cystectomy 2013–2024 in the S

The Cytotoxic and Genotoxic Effects of Conjugated Trans-2-Nonenal (T2N), an Off-Flavor Compound in Beer and Heat Processed food Arising from Lipid Oxidation

This study investigates the toxic effect of E(2)nonenal (trans-2-nonenal, T2N) and its conjugate with horse muscle myoglobin (Mb) tested on murine cell line L929 and human cell line A549, as well as the genotoxic effect of these compounds assayed by measuring of micronuclei in human cells K562. It is an aldehyde, which is occurring as the substance responsible for an off flavour in aged beers, but

Respiratory gating for proton beam scanning versus photon 3D-CRT for breast cancer radiotherapy

Background Respiratory gating and proton therapy have both been proposed to reduce the cardiopulmonary burden in breast cancer radiotherapy. This study aims to investigate the additional benefit of proton radiotherapy for breast cancer with and without respiratory gating. Material and methods Twenty left-sided patients were planned on computed tomography (CT)-datasets acquired during enhanced insp

Refining laissez-faire treatment of periocular tumour defects by exploring the impact of defect localization and geometry on the healing process

Background: Large lower eyelid defects resulting from tumour removal are frequently reconstructed using a tarsoconjunctival flap from the upper eyelid together with an overlying free skin graft, the so-called Hughes procedure. One disadvantage of this technique is that the tarsoconjunctival flap occludes the eye during the revascularization of the graft, which is particularly troublesome for patie