Search results

Objectives: To investigate the preoperative prognostic value of molecular subtypes in relation to clinical information, histopathological findings, and molecular markers for patients with bladder cancer treated with radical cystectomy. Patients and methods: After standard preoperative staging, a population-based cohort of 519 patients underwent radical cystectomy between 2006 and 2011. Following

Grading based on histopathologic features is used to predict survival in soft‐tissue sarcoma. However, variations in clinical behavior between tumors of the same grade motivate a search for additional factors that correlate with prognosis. Proliferating cell nuclear antigen (PCNA) is expressed in proliferating cells during the G 1 S and G 2 ‐phases. To evaluate a prognostic implication of PCNA, t

The eastern part of the Svalbard archipelago and the adjacent areas of the Barents Sea were subject to extensive erosion during the Late Weichselian glaciation. Small remnants of older sediment successions have been preserved on Edgeoya, whereas a more complete succession on Kongsoya contains sediments from two different ice-free periods, both probably older than the Early Weichselian. Ice movemeh

An interaction of mitochondrial creatine kinase with purified outer mitochondrial porin (voltage-dependent anion channel) was shown by co- sedimentation assays as well as by gel permeation chromatography. Porin formed high M(r) complexes with wild-type mitochondrial creatine kinase as well as with an N-terminal deletion mutant, lacking the first five N-terminal amino acids. The complexes were iden

The electric field response of the lead-free solid solution (1-x)Bi0.53Na0.47TiO3-xBaTiO3 (BNT-BT) in the higher BT composition range with x = 0.12 was investigated using in situ synchrotron X-ray powder diffraction. An introduced Bi-excess non-stoichiometry caused an extended morphotropic phase boundary, leading to an unexpected fully reversible relaxor to ferroelectric (R-FE) phase transformatio

BACKGROUND: Before this study started, the standard postoperative chemotherapy regimen for stage II-III Wilms' tumour pretreated with chemotherapy was to include doxorubicin. However, avoidance of doxorubicin-related cardiotoxicity effects is important to improve long-term outcomes for childhood cancers that have excellent prognosis. We aimed to assess whether doxorubicin can be omitted safely fro

PURPOSE: The R2Pulm trial was conducted to evaluate the effect of busulfan-melphalan high-dose chemotherapy with autologous stem-cell rescue (BuMel) without whole-lung irradiation (WLI) on event-free survival (main end point) and overall survival, compared with standard chemotherapy with WLI in Ewing sarcoma (ES) presenting with pulmonary and/or pleural metastases. METHODS: From 2000 to 2015, we e

Background: Tamoxifen is a well established treatment for breast cancer, but its long-term effects on the incidence of secondary cancers are not fully evaluated. Material and methods: We have studied 4128 postmenopausal patients with early stage breast cancer who were alive and free of breast cancer recurrence after two years of tamoxifen, and who were randomized to receive totally two or five yea

Multidimensional LC-MS based shotgun proteomics experiments at the peptide level have traditionally been carried out by ion exchange in the first dimension and reversed-phase liquid chromatography in the second. Recently, it has been shown that isoelectric focusing (IEF) is an interesting alternative approach to ion exchange separation of peptides in the first dimension. Here we present an improve

A microstrip antenna design is introduced in which a rectangular microstrip patch is coupled electromagnetically with a gridded rectangular patch placed above. The gridded patch consists of nine identical rectangular parts separated by a distance which is much smaller than a free space wavelength for a central frequency. The antenna is designed to operate in the 60 GHz band and is fabricated on a

To improve the prognosis of patients with pancreatic cancer, new biomarkers are required for earlier, pre-symptomatic diagnosis. Epigenetic mutations take place at the earliest stages of tumorigenesis and therefore offer new approaches for detecting and diagnosing disease. Nucleosomes are the repeating subunits of DNA and histone proteins that constitute human chromatin. Because of their release i

CYLD is a deubiquitinating (DUB) enzyme that has a pivotal role in modulating nuclear factor kappa B (NF-κB) signaling pathways by removing the lysine 63- and linear-linked ubiquitin chain from substrates such as tumor necrosis factor receptor-associated factor 2 (TRAF2) and TRAF6. Loss of CYLD activity is associated with tumorigenicity, and levels of CYLD are lost or downregulated in different ty

We prospectively assessed the subjective, objective, and radiographic results at 1, 2, and 5 years in 65 patients who had pyrocarbon proximal interphalangeal prostheses inserted between 2001 and 2010. Further operations were done on 10 of the 89 joints (four for prosthetic extraction and arthrodesis, two for component changes, and four for soft tissue procedures). At 1 year, the visual analogue sc

We investigate the competition between the associations of oppositely charged protein-surfactant complexes and oppositely charged surfactant complexes. In all systems examined, the most favorable complexation is the one between the two oppositely charged surfactant ions, despite the strong binding known, for example, dodecyl sulfate, DS-, to lysozyme. Thus, the phase behavior of the catanionic sys

In free flap surgery, restored blood flow following a lengthy ischaemic period may lead to necrosis as a result of ischaemia/reperfusion (IR) injury. This injury comprises both proinflammatory and prothrombotic events, where the tissue factor/factor VIIa complex probably has a key role. Active site-inactivated factor VIIa (FFR-rFVIIa) exerts an antithrombotic effect by binding to tissue factor wit

The effects of 2,3-butanedione monoxime (BDM) on intracellular Ca2+ transient and cross-bridge function were studied in frog single fibres from the anterior tibialis muscle of Rana temporaria (sarcomere length, 2.2 m; temperature, 24 C). The fluorescent dye fluo-3 was used to monitor the intracellular free calcium concentration ([Ca2+i) during isometric contractions. BDM (15 m M) reduced the ampli

1. The structure of chondroitin/dermatan and heparan-sulphate chains from various proteoglycan populations derived from cultured human skin fibroblasts have been examined. Confluent cell cultures were biosynthetically labelled with [3H]-glucosamine and 35SO4(2-), and proteoglycans were purified according to buoyant density, size and charge density [Schmidtchen, A., Carlstedt, I., Malmstrom, A. &am

The RGD sequence is present in many extracellular matrix proteins and intracellular proteins, including caspases. Synthetic RGD peptides may affect adhesion, migration and tumour metastasis, or directly induce apoptosis. Several RGD peptides were synthesised, and their anti-adhesive and cytotoxic properties were analysed in vitro. The most active peptide (poly RGD) was also tested in vivo to asses

I skrivande stund är sju olika cancercentra i Sverige, däribland Skånes Universitetssjukhus i Lund, mitt uppe i en gemensam randomiserad studie som undersöker behandling av prostatacancer med två olika strålningsscheman. Patienterna i studien blir slumpvis tilldelade antingen en standardbehandling, där de får en liten mängd strålning vid 39 olika tillfällen, eller en så kallad hypofraktionerad behPurpose: This work examined the feasibility of flattening filter free (FFF) volumetric modulated arc therapy (VMAT) for extreme hypofractionation of prostate cancer. The aim was to investigate the potential gain in treatment time per fraction for extreme hypofractionation of prostate cancer, while preserving or improving the treatment plan quality and radiation delivery quality. The impact of intr

Research shows that pornography holds great influential power in relation to the sexual desires and preferences of its consumers, and that it greatly affects how people view sex and intimacy. When pornography displays acts of sexual violence, acts of aggressions, this influential power constitutes a cause for concern. It has been shown that consumption of pornography featuring aggression contribut