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Objective. The aim of this study was to present the outcome of patients treated with salvage cryotherapy after radiotherapy for prostate cancer at one institution. Materials and methods. Consecutive patients treated between 2007 and 2013 with transperineal cryotherapy for biopsy-verified local recurrence after radiotherapy were investigated. An external reviewer retrieved outcome data retrospectiv
Tumor growth in the pelvis with nerve involvement causes severe pain which is notoriously resistant to pharmacological treatment. Chordotomy is a classical method for the relief of pain. This is a retrospective study of 24 chordotomy cases, operated on at the department of Neurosurgery, and independently evaluated at the department of Gynecologic Oncology. Initially 19 patients (79%) were painfree
Human tumors xenografted in immunodeficient mice are crucial models in nuclear medicine to evaluate the effectiveness of candidate diagnostic and therapeutic compounds. However, little attention has been focused on the biological profile of the host model and its potential effects on the bio-distribution and tumor targeting of the tracer compound under study. We specifically investigated the dissi
Importance: Multiple myeloma is consistently preceded by monoclonal gammopathy of undetermined significance (MGUS). Risk models that estimate the risk of progression from MGUS to multiple myeloma use data from a single time point, usually the initial workup. Objective: To longitudinally investigate the alterations of serum immune markers with stable vs progressive MGUS. Design, Setting, and Partic
DNA ExtractionWe recommend Qiagen spin column-based nucleic acids purification methods. Concentration and PurityUse spectrophotometrical method to get the concentration and a ratio (OD260/280 and OD260/230) of each sample.DNA should have an OD260/280 ratio ~1.8 and OD260/230 ratio in range 1.8-2.2 (the ratio shows purity of samples).DNA amount recommendedMethylation: Bisulfitconversion: 555 ng DNA
https://www.ctg.lu.se/genomic-services/array/sample-requirement - 2026-05-11
Work-life balance är ett arbetsmiljöproblem som är av ökande relevans på både organisations- och individnivå. Ämnet är särskilt relevant för gymnasielärare, ett yrke som har sett en ökad grad av utbränning och långtidssjukskrivning under de senaste åren. Studien syftar till att analysera hur gymnasielärares fritid, arbete och work-life balance hänger samman och påverkar varandra och ifall det finnWork-life balance is a workplace issue that is increasing in relevance at both the organizational and individual levels. The topic is particularly relevant for high school teachers, a profession that has seen a rise in burnout and long-term sick leave in recent years. The study aims to analyze how high school teachers free time, work, and work-life balance are interconnected and influence each oth
The prognostic impact of t(12;21)(p13;q22) [ETV6/RUNX1 fusion] in paediatric acute lymphoblastic leukaemia (ALL) has been extensively debated, particularly with regard to the frequency of late relapses and appropriate treatment regimens. We have retrospectively collected 679 ALLs with known ETV6/RUNX1 status, as ascertained by fluorescence in situ hybridization or reverse-transcription polymerase
Overtime copensation | Akademikerföreningen at Scania and TRATON Hoppa till huvudinnehåll Join us Here's why We are members GDPR and how we process personal data Become a trustee Contact person Safety officer Member of the Board Member of the Election Committee Auditor Roadmap and initiatives Roadmap Work environment Salary, Benefits and Competence development Transformation Salary Increase your s
PURPOSE: Prostate-specific antigen (PSA) defined biochemical recurrence (BCR) of prostate cancer is widely used for reporting the outcome of radical prostatectomy (RP). A standardized BCR definition is lacking, and overall progression-free probability and risk of subsequent metastatic disease progression may vary greatly depending on the PSA criterion used. Ten definitions of BCR were evaluated to
Despite the favorable prognosis of childhood acute lymphoblastic leukemia (ALL), a substantial subset of patients relapses. Since this occurs not only in the high risk but also in the standard/intermediate groups, the presently used risk stratification is suboptimal. The underlying mechanisms for treatment failure include presence of genetic changes causing insensitivity to the therapy administere
Background: Liver cirrhosis is characterized by a silent phase until decompensation, which is defined by ascites, bleeding from esophageal varices or hepatic encephalopathy. Aim: We compare the clinical course, patterns of survival and causes of death by etiology during long-term follow-up in a large population-based cohort of patients with incident cirrhosis. Material and methods: We used populat
BACKGROUND: Prognosis in Parkinson's disease (PD) remains poorly understood due to a lack of unbiased data on the natural history of treated PD. The CamPaIGN study has been the first to prospectively track disease evolution from diagnosis in an unselected population-representative incident cohort. We now report the 10-year follow-up data, focusing on three key irreversible milestones: postural ins
Type III protein S deficiency is characterized by a low plasma level of free protein S, whereas the total concentration of protein S is normal. In contrast, both free and total protein S levels are low in type I deficiency. To elucidate the molecular mechanism behind the selective deficiency of free protein S in type III deficiency, the relationship between the plasma concentrations of β-chain con
Objective: Sex cord-stromal tumours of the ovary are relatively uncommon neoplasms that account for 3 % of all ovarian cancers. Uterine preservation with careful staging is achievable; however, conservative surgery remains controversial. This study examined the prognostic effects of uterine preservation in patients with stage I sex cord-stromal tumours. Study design: This retrospective cohort stud
We have designed a new class of microdevices composed of a supporting plastic (polyvinyl chloride, PVC) plate integrated with a groove for a piece of fused silica capillary (the separation channel), a slit for on-tube detection, an “islet” for the application of sample, electrode vessels and platinum electrodes. The design permits electrophoretic, electrochromatographic and chromatographic separat
fågelåret 2018194 LUVRE 2018 Figur 1. Antalet adulta sävsparvar i den standardisera- de ringmärkningen på sommaren har minskat markant under åren 1984–2018. Antalet fångade ungfåglar per adult fågel varierar mellan åren, men det finns ingen sig- nifikant förändring över åren. martin green & åke lindström Inom LUVRE-projektet (Lund University Vin- del River Expedition) bedrivs fågelövervakning och
https://www.luvre.lu.se/sites/luvre.lu.se/files/fagelaret_2018_luvre.pdf - 2026-05-12
Purpose Although there is evidence for interaction between epidermal growth factor receptor ( EGFR) and estrogen receptor ( ER), it is still not clear how this affects response to endocrine therapies like tamoxifen. Here we assess the relationship between EGFR expression and tamoxifen response, with a new quantitative technology. Patients and Methods A tissue microarray was constructed from breast
Background: Accurate prehospital trauma triage is crucial for identifying critically injured patients and determining the level of care. In the prehospital setting, time and data are often scarce, limiting the complexity of triage models. The aim of this study was to assess whether, compared with logistic regression, the advanced machine learner XGBoost (eXtreme Gradient Boosting) is associated wi
OBJECTIVE: Mortality caused by coronary artery disease has markedly decreased in recent years. However, a substantial proportion of patients suffering a coronary event (CE) die within the first day, most of them out of hospital. We aimed to investigate how established cardiovascular (CV) risk factors and CV autonomic indices associate with fatal versus non-fatal CEs in the population.METHODS: 33 0
