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Background: Conservative management is an option for prostate cancer (PCa) patients either with the objective of delaying or even avoiding curative therapy, or to wait until palliative treatment is needed. PIONEER, funded by the European Commission Innovative Medicines Initiative, aims at improving PCa care across Europe through the application of big data analytics. Objective: To describe the cli

Background: Premeal whey protein (WP) consumption may reduce postprandial glucose (PPG) levels and appetite. We assessed the effects of twice daily consumption of a low-dose non-gelling novel WP formulation (WP microgel [WPM]) on PPG, self-reported appetite, and ad-libitum food consumption. Methods: This was a randomized, prospective, open-label, controlled, single-center crossover study, and adul

Background: Early-stage triple-negative breast cancer (TNBC) displays clinical and biological diversity. From a biological standpoint, immune infiltration plays a crucial role in TNBC prognosis. Currently, there is a lack of genomic tools aiding in treatment decisions for TNBC. This study aims to assess the effectiveness of a B-cell/immunoglobulin signature (IGG) alone, or in combination with tumo

BackgroundIt remains unclear as to why some individuals at low risk of cardiovascular disease (CVD) develop severe coronary atherosclerosis, while those at high CVD risk may remain free from coronary atherosclerosis.PurposeUsing Coronary Computed Tomography Angiography (CCTA), we aimed to identify factors associated with absence and severe coronary atherosclerosis in subjects from the general popu

Inhalation therapy treating severe infectious disease is among the more complex and emerging topics in controlled drug release. Micron-sized carriers are needed to deposit drugs into the lower airways, while nano-sized carriers are of preference for cell targeting. Here, we present a novel and versatile strategy using micron-sized spherical particles with an excellent aerodynamic profile that diss

We have evaluated capacitive and thermal transducers for recognition of bio- molecular interactions with different analytes. These assays were made in flow analysis systems because of the simplicity such methods provide. A capacitive transducer, based on a surface modified gold electrode, has the ability to monitor affinity based interactions directly, provided that the interactions introduce mea

Popular Abstract in Swedish Denna avhandling behandlar tillväxt av och elektriska mätningar på halvledande nanotrådar av indiumarsenid (InAs) och kombinationer av InAs och indiumfosfid (InP). En nanotråd är som namnet antyder en tunn solid tråd, som påminner om ett hårstrå fast med en diameter på typiskt 50 nm (en nanometer är en miljarddels meter, 10^-9 m) och längden kan vara allt från 100 nm upIn this thesis, semiconductor nanowires are studied from the point of view of growth and electrical properties. The growth of nanowires is done by chemical beam epitaxy (CBE), an ultra-high vacuum technique allowing a precise control of precursor deposition and low growth rates. In conventional epitaxy, growth is usually two or three- dimensional, depending on growth conditions and material combin

Popular Abstract in Swedish Helicobacter pylori är troligen världens vanligaste bakterieinfektion och mer än 50% av jordens befolkning är infekterad. Bakterien orsakar kronisk magkatarr vilket kan utvecklas till sår både i magsäcken och i tolvfingertarmen, samt till magcancer. Behandling med antibiotika, som dödar bakterien, och syrahämmande läkemedel har revolutionerat behandlingen av magsår, somThe Gram-negative genus of Helicobacter consists of many bacterial species that colonize a wide range of animal hosts. The genus can be divided into gastric species that colonize the stomach, and enteric species that preferentially colonize the colon and biliary tree of various animal hosts. Helicobacter pylori cause gastritis, gastro-duodenal ulcer disease and gastric adenocarcinoma and lymphoma

Shrines and Souls provides a multi-layered contextualization of the article on religious liberty in the Universal Declaration of Human Rights (Article 18), which was propounded by the United Nations General Assembly on December 10, 1948. It shows how the framers of the Declaration decided to break with some of the conventional ways of framing religious liberty in international law, by foregroundin

All cellular organisms in aquatic environments are susceptible to virus attack. Viruses are the smallest but most abundant biological entities in freshwaters. This thesis describes interactions between viruses and bacteria in temperate and polar freshwaters with particular emphasis on Arctic and Antarctic aquatic systems. Free virus-like particles in freshwaters are vulnerable and exposed and as p

Accurate radiation dosimetry is of paramount importance in order to ensure safe delivery of radiotherapy, and for the possibility of meaningful evaluation of clinical trials, as the radiation absorbed dose is correlated to tissue response. The aim of the studies described in this thesis was to investigate and devise novel approaches to mixed beam dosimetry in boron neutron capture therapy (BNCT).

Background No effective standard treatment exists for patients with radioiodine-refractory, advanced differentiated thyroid carcinoma. We aimed to assess efficacy and safety of vandetanib, a tyrosine kinase inhibitor of RET, VEGFR and EGFR signalling, in this setting. Methods In this randomised, double-blind, phase 2 trial, we enrolled adults (aged >= 18 years) with locally advanced or metastatic

BACKGROUND: The effect of acupuncture on nociceptive pain is well documented, but effects on nociceptive itch have been contradictory. OBJECTIVES: To evaluate possible effects of acupuncture on the occurrence, distribution and function of sensory nerve fibres in human skin. METHODS: Ten subjects were treated by inserting 10 acupuncture needles subcutaneously at the upper lateral aspect of one butt

In everyday life, we bind visual samples of the world into a coherent episodic memory via eye movements. Previous eye tracking research revealed that visual scrutiny, gaze transitions between event elements, and refixations during encoding predict successful memory formation. However, little is known about the neural mechanisms of these processes. Here, we combine EEG and eye tracking to investiga

I ett entreprenadavtal kan parterna avtala om att arbetena ska ersättas på löpande räkning. AB 04 innehåller bestämmelser om att ersättning på löpande räkning ska betalas enligt den så kallade självkostnadsprincipen. Syftet med den här uppsatsen har varit att utreda och analysera vilka ekonomiska risker självkostnadsprincipen kan innebära för beställaren och vilka möjligheter beställaren har att sThe parties in a construction contract can stipulate that the construction works are to be compensated on an open account basis. AB 04 states that compensation on an open account basis is to be paid according to the prime cost principle. The purpose of this thesis has been to examine and analyse the financial risks that the prime cost principle means for the employer, and which prospects the emplo

Eoliska sanddyner är en sällan undersökt resurs ur ett paleoklimatperspektiv. Genom att undersöka dynernas geomorfologi och strukturer kan de klassificeras som olika dyntyper. Eoliska sanddyner kräver speciella omständigheter och förutsättningar för att bildas och agerar värdefulla klimatarkiv för de tidperioder då de avsatts. Dessa klimatarkiv kan berätta om den lokala miljön gällande bland annatAeolian sand dunes is a seldom studied resource from the perspective of paleoclimates. By analysing the dunes geomorphology and structures they can be classified into different type of dunes. Aeolian dunes require special circumstances and conditions to be met to enable their deposition. The sand dunes can then act as precious climate archives for the time periods during which they were formed. Th

Högsta domstolen har genom det s.k. juniavgörandet fastslagit att ne bis in idem-principen utgör hinder för att i olika processer påföra skattetillägg och åtala för skattebrott för samma oriktiga uppgift i en inkomstdeklaration. Enligt det senare s.k. juliavgörandet gäller förbudet mot dubbla sanktioner retroaktivt sedan den 10 februari 2009. Syftet med denna uppsats är att utreda orsaken till ocA court ruling came through the Swedish Supreme Court to declare that the ne bis in idem principle prevents various processes for tax surcharges and prosecution for tax offenses due to the same acts of providing false information in an income tax return (the June ruling). A later ruling prohibits the two sanctions and it has been applied retroactively since 10th February 2009 (the July ruling). T

Popular science summary: The European silver eel oceanic migration During the past 30 years the population of the European silver eel has been declining dramatically. This is a commercially important species and several action plans have been established but little information about the biology of the European eel is known. During the EELIAD project female silver eels were electronically tagged

Popular science summary Non steroid anti-inflammatory drugs (NSAIDs) are among the most consumed pharmaceuticals worldwide, and thus belong to the most frequently identified pharmaceuticals in aquatic environments. Until now multiple examinations have shown adverse effects of NSAIDs on life functions of aquatic organisms even in low concentrations. However, there is still lack of data about toxic

I en allt mer globaliserad värld präglad av konstant gränsöverskridande handel är det av yttersta vikt att beskattningen av gränsöverskridande transaktioner fungerar tillfredsställande. Detta gäller även de fall då avkastning på finansiella instrument korsar länders gränser. I svensk rätt liksom i många andra länders rätt saknas klara definitioner för vad som är ränta och vad som är utdelning. DetIn a progressively more globalized world featuring constant cross-border trade it is imperative that the taxation of cross-border transactions is carried out in a satisfactory manner. This is also true regarding periodic income from financial instruments. In Swedish tax law as well as in many other countries there is no clear definition of what constitutes interest and dividends. Large multination