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Background Treatment of severe hemophilia A (SHA) with FVIII concentrates is complicated by the development of neutralizing inhibitors in about 30% during the first 50 exposure days (EDs). Despite extensive research, inhibitor risk of different FVIII concentrates remains to be elucidated. Objectives This study aimed to analyze inhibitor development according to (classes of) individual FVIII concen
PURPOSE: We aimed to develop a predictive tool for anastomotic leakage (AL) following colon cancer surgery by combining a clinical early warning score (EWS) with the C-reactive protein (CRP) level.METHODS: The records of 1,855 patients who underwent colon cancer surgery at the Oxford University Hospitals NHS Foundation Trust between January 2013 and December 2018, with or without AL, were retrospe
BACKGROUND: Intestinal resection and a proximal stoma is the preferred surgical approach in patients with severe secondary peritonitis due to perforation of the small intestine. However, proximal stomas may result in significant nutritional problems and long-term parenteral nutrition. This study aimed to assess whether primary anastomosis or suturing of small intestine perforation is feasible and
The EU's Clean Energy Package introduced renewable and citizen energy communities (RECs/CECs) to strengthen citizen participation in electricity markets. Nordic countries, however, have long-standing traditions of community-based energy provision, including district heating cooperatives, small hydropower schemes, and wind cooperatives. This article examines how nationally embedded energy models in
Background: Clinical supervisors’ competence is central to student learning, particularly in the context of existing practical, organizational, and resource-related challenges in simulation-based education. This study explored clinical supervisors’ experience of acting as instructors during simulation-based learning in specialist nursing education in anesthesia and intensive care. Method: An explo
Given the reproducing kernel k of the Hilbert space Hk we study spaces Hk(b) whose reproducing kernel has the form k(1−bb⁎), where b is a row-contraction on Hk. In terms of reproducing kernels this is the most far-reaching generalization of the classical de Branges-Rovnyaks spaces, as well as their very recent generalization to several variables. This includes the so called sub-Bergman spaces [31]
Canopy decline is increasingly prevalent in high-elevation snow gum (Eucalyptus pauciflora) forests across the Australian Alps. This phenomenon, known as snow gum dieback, is associated with infestations by the wood-boring beetle, Phoracantha mastersi. The larvae of this beetle create feeding galleries in the tree trunk, leading to the exudation of kino, a tannin-rich resin produced as a defense r
The traditional approach to quantum parameter estimation focuses on the quantum state, deriving fundamental bounds on precision through the quantum Fisher information. In most experimental settings, however, performing arbitrary quantum measurements is highly unfeasible. In open quantum systems, an alternative approach to metrology involves the measurement of stochastic currents flowing from the s
We study the time complexity of computing the (min,+) matrix product of two n×n integer matrices in terms of n and the number of monotone subsequences the rows of the first matrix and the columns of the second matrix can be decomposed into. In particular, we show that if each row of the first matrix can be decomposed into at most m1 monotone subsequences and each column of the second matrix can b
Background: Cystic fibrosis related diabetes (CFRD) is the most common comorbidity of cystic fibrosis (CF) still, its pathogenesis is poorly understood. Recent studies have suggested that although pancreatic insufficiency is an important explanation for CFRD development, inherent pancreatic islet cell dysfunction may play a role. This study aimed to systematically compile current data regarding th
This paper considers the beta exponential distribution as a distribution function of inefficacy score in a stochastic frontier model. The beta exponential distribution is a three-parameter distribution, and it is more flexible than commonly used probability density functions in a stochastic frontier model (SFM). This new model, a “Normal-Beta Exponential SFM”, nests another five SFMs. This paper p
Approximately 1.9 million Colombians lacked access to clean and reliable energy in 2020 due to residing in rural non-interconnected zones (NIZ). This lack of reliable electricity is compounded by their geographical isolation which makes them unable to access the National Interconnected System of energy (SIN). Renewable energy microgrids serve as a potential decentralised solution to provide clean
Understanding the role of intrinsic magnetic order on the oxygen evolution reaction (OER) requires careful consideration of the magnetic properties of both the catalytic surface and bulk under operating conditions. Because these often diverge from those of the pristine material, operando characterization that directly links magnetic behavior to catalytic activity is essential. Here, we investigate
Sodium dodecyl sulfate (SDS) forms elongated micelles in urea:choline chloride deep eutectic solvent (DES), unlike its spherical aggregates in water. To understand the driving forces, we employed a multiscale simulation approach combining coarse-grained (CG) (Martini 3) and backmapped atomistic (CHARMM36) models. Simulations confirmed that micelle elongation increases with higher urea:choline chlo
Reflexivity constitutes a core professional competence in social work and needs to be promoted in social work education. In this case study of an autobiography-based course element, it is shown how social work students (n = 13) realized reflexivity from within (i) their experiences of engaging with autobiographical literature and (ii) their discussions of those experiences in peer groups. The case
The Siljan-Orsasjön Basin in south-central Sweden hosts two prominent lakes. A 100 m deep channel extends approximately 52 km across the basin but does not form a continuous connection between the lakes today. Geophysical mapping, including multibeam bathymetry and sub-bottom profiling, revealed several landslide areas associated with the steep slopes of this channel and redistributed mass-wasted
Background: Survivors of cardiac arrest often face multifaceted challenges—cognitive, emotional, physical, and existential—that extend beyond clinical recovery. Despite these long-term consequences, follow-up care is often insufficient, and access to reliable information and support remains limited. Broader initiatives to address post–cardiac arrest care are still lacking. This qualitative study rBackground: Survivors of cardiac arrest often face multifaceted challenges—cognitive, emotional, physical, and existential—that extend beyond clinical recovery. Despite these long-term consequences, follow-up care is often insufficient, and access to reliable information and support remains limited. Broader initiatives to address post–cardiac arrest care are still lacking. This qualitative study r
Purpose: Long-standing symptoms have been reported after COVID-19 infection, which can negatively impact daily life and work. The purpose of this study was therefore to describe work ability and explore factors associated with poor work ability among individuals with Post COVID-19 Condition (PCC). Methods: We did an online survey among individuals with self-reported PCC. Descriptive statistics and
