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Acute myeloid leukemia (AML) is a highly heterogeneous disease caused by sequential accumulation of mutations in the genome of hematopoietic stem cells (HSCs) or myeloid precursors, giving rise to formation of leukemia stem cells (LSC). More than 200 recurrent mutations have been described, although each patient will carry a small subset of these. The mutations are used as a basis for classificati
