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Tamoxifen prevents recurrence of breast cancer and is suggested for preventive risk-reducing therapy. Tamoxifen reduces mammographic density, a proxy for therapy response, but little is known about its effects in remodelling normal breast tissue. Our study, a substudy within the double-blinded dose-determination trial KARISMA, investigated tamoxifen-specific changes in breast tissue composition an
Introduction: Questioning the Democratic Legitimacy of European Penal Law In Western political systems it is elemental that legislation must have a democratic source in order to be legitimate. Above all, democratic legitimacy is regarded as important with reference to penal legislation, since penal power is paradigmatically the most intrusive form of political power. Therefore, it is generally ack
Collaboration is essential to the conduct of basic, applied and clinical research and its translation into the technologies and treatments urgently needed to improve the lives of people living with brain diseases and the health professionals who care for them. EPICLUSTER was formed in 2019 by the European Brain Research Area (EBRA) to support the coordination of epilepsy research in Europe. A key
De senaste åren har det kommit många prejudikat rörande medansvar vid kritisk kapitalbrist i 25 kap. aktiebolagslagen (ABL). I ett nytt prejudikat klargör Högsta domstolen när ett aktiebolags förpliktelse att lämna ersättning för rättegångskostnader ska anses ha uppkommit vid tillämpning av 25 kap. 18 § ABL. Trots den ofta upprepade utgångspunkten att reglernas ändamål är att verka handlingsdirige
Anna Lindberg, Anna Lundberg och Mehek Muftee har läst och analyserat barnfamiljers asylakter. I denna artikel visar de med hjälp av olika exempel hur tid ges en central roll i Migrationsverkets utredningsarbete, som närmast låter sig beskrivas som en frenetisk jakt på kronologiska berättelser. Glapp i tidskronologin och tveksamma svar på frågor som rör tid resulterar i att den asylsökande misstän
Aquaglyceroporin 7 (AQP7) facilitates glycerol flux across the plasma membrane with a critical physiological role linked to metabolism, obesity, and associated diseases. Here, we present the single-particle cryo-EM structure of AQP7 determined at 2.55 Å resolution adopting two adhering tetramers, stabilized by extracellularly exposed loops, in a configuration like that of the well-characterized in
Starch modified with octenyl succinic anhydride (OSA) is extensively used due to its emulsifying capacity. Modification with OSA renders the starch surface active but also anionic at intermediate pH. The amount of OSA that is grafted to the starch polymer backbone will influence the functionality. Likewise, it can be expected that the distribution of the substituents over the molar mass distributi
BACKGROUND: Movement disorders are frequent in patients with inborn errors of metabolism (IEMs) but poorly recognized, particularly by nonmovement disorder specialists. We propose an easy-to-use clinical screening tool to help recognize movement disorders.OBJECTIVE: The aim is to develop a user-friendly rapid screening tool for nonmovement disorder specialists to detect moderate and severe movemen
Ensuring the conditions for an inclusive society in the face of humandiversity places various demands on the built environment. Planning isessential for accommodating a wide range of individual preferences andabilities.This article examines the presence and absence of Universal Design (UD)in contemporary urban planning and construction in eight new or remodelledSwedish building and public space pr
