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Purpose: More than 70% of patients with breast cancer present with node-negative disease, yet all undergo surgical axillary staging. We aimed to define predictors of nodal metastasis using clinicopathological characteristics (CLINICAL), gene expression data (GEX), and mixed features (MIXED) and to identify patients at low risk of metastasis who might be spared sentinel lymph node biopsy (SLNB).Exp
Changes in the characteristics of cyclone activity (frequency, depth and size) in the Arctic are analyzed based on simulations with state-of-the-art regional climate models (RCMs) from the Arctic-CORDEX initiative and global climate models (GCMs) from CMIP5 under the Representative Concentration Pathway (RCP) 8.5 scenario. Most of RCMs show an increase of cyclone frequency in winter (DJF) and a de
Understanding the transition of biosphere‐atmosphere carbon exchange between glacial and interglacial climates can constrain uncertainties in its future projections. Using an individual‐based dynamic vegetation model, we simulate vegetation distribution and terrestrial carbon cycling in past cold and warm climates and elucidate the forcing effects of temperature, precipitation, atmospheric CO2 con
In this paper, we study activity on Twitter in relation to the Swedish political festival Almedalsveckan, a week-long event where political parties, interest organizations, corporations and other actors for decades have gathered on the island of Gotland to discuss politics and public affairs. In 2018, a total of 4311 events (speeches, seminars, debates etc.) were arranged by 1929 separate actors a
A major part of this thesis work has been research in a medical project, where, together with industry and clinical partners, the aim was to develop a prototype system for non-invasive monitoring of premature babies based on the optical measurement technique gas in scattering media absorption spectroscopy (GASMAS). Part of the project was to develop a 3D-printed tissue phantom based on chest X-ray
Introduction. The aim of this paper is to critically examine how public libraries are portrayed as contributing to social sustainability. Meanings ascribed to the concept are investigated and if, and then how, the public library is shaped in relation to it.Method. Library plans from five municipalities in Sweden are analysed and discussed in the light of previous research. Analysis. Bacchi’s metho
Overcoming cellular growth restriction, including the evasion of cellular senescence, is a hallmark of cancer. We report that PAK4 is overexpressed in all human breast cancer subtypes and associated with poor patient outcome. In mice, MMTV-PAK4 overexpression promotes spontaneous mammary cancer, while PAK4 gene depletion delays MMTV-PyMT driven tumors. Importantly, PAK4 prevents senescence-like gr
In discussions of Scandinavian democratization, it is commonplace to argue that long- standing farmer representation in parliament and a lack of feudalism encouraged a democratic-participatory civic culture within the peasant farmer class – or perhaps in the population as a whole. The present essay questions this interpretation in the Swedish case. It centers on a re-interpretation of farmer polit
The insect odorant receptors (ORs) are amongst thelargest gene families in insect genomes and the primarymeans by which insects recognize volatile compounds.The evolution of ORs is thus instrumental inexplaining the chemical ecology of insects and as amodel of evolutionary biology. However, althoughORs have been described from numerous insect species,their analysis within and amongst the insectord
This study explores if self-control predicts exercise ambition and actual exercise, and if exercise ambition predicts actual exercise. Members and guests at a not-for-profit sports club were invited to participate. 264 individuals completed a self-reported (Self-Control Scale) measure of self-control, and responded to questions about actual exercise as well as exercise ambition prior to their work
This thesis aims to develop new synthetic methods and explore the possibilities to apply it in the total synthesis of natural products.Chapter 2 deals with a mild procedure for the synthesis of a-keto amides by a-oxidation of the corresponding aketo amines mediated by pyrrolidine and TEMPO. The method can also be applied to the synthesis of a-keto thioamides and a-keto amidines.Chapter 3 deals witThis thesis aims to develop new synthetic methods and explore the possibilities to apply it in the total synthesis of natural products.Chapter 2 deals with a mild procedure for the synthesis of a-keto amides by a-oxidation of the corresponding aketo amines mediated by pyrrolidine and TEMPO. The method can also be applied to the synthesis of a-keto thioamides and a-keto amidines.Chapter 3 deals wit
In idiopathic pulmonary fibrosis (IPF) structural properties of the extracellular matrix (ECM) are altered and influence cellular responses through cell-matrix interactions. Scaffolds (decellularized tissue) derived from subpleural healthy and IPF lungs were examined regarding biomechanical properties and ECM composition of proteins (the matrisome). Scaffolds were repopulated with healthy fibrobla
Studies evaluating the relationship between platelet indices and cardiovascular (CV) outcomes yielded conflicting results. We assessed the incidence of adverse events according to baseline quintiles of platelet indices in the prospective cohort of the Malmö Diet and Cancer Study. A total of 30,314 individuals (age 57 ± 8 years) were followed for a median of 16 years (468,490 person-years). Outcome
BACKGROUND: Low resting heart rate and premature atrial contractions (PACs) predict incident atrial fibrillation (AF) and could be interdependent, since PACs occur in the gaps between normal beats.OBJECTIVE: To study the association between low heart rate at 24hECG, PACs and incident AF in a prospective population-based cohort.METHODS: In the Malmö Diet and Cancer study, 24hECGs were performed in
