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Stem cell engineering and grafting of mesencephalic dopamine (mesDA) neurons is a promising strategy for brain repair in Parkinson's disease (PD). Refinement of differentiation protocols to optimize this approach will require deeper understanding of mesDA neuron development. Here, we studied this process using transcriptome-wide single-cell RNA sequencing of mouse neural progenitors expressing the
Near field Inverse Synthetic Aperture Radar Cross Section (RCS) measurements are used in this study to obtain geometrically correct images of objects placed on a turntable. The images of the targets are processed using a method common in the compressive sensing field, Basis Pursuit Denoise. A near field model based on isotropic point scatterers is set up. The target model is naturally sparse and t
Lead is a heavy metal which is toxic even at low exposure levels. Although the amount of lead used in industry is steadily declining, it still constitutes a common alloying element for most conventional brass varieties. Today, conventional brasses contain roughly 3 wt % lead. One of the main incentives for using lead as an alloying element is that it has a markedly positive effect on the machinabi
Stem cell treatments for neurodegenerative diseases are expected to reach clinical trials soon. Most of the approaches currently under development involve transplantation of immature progenitors that subsequently undergo phenotypic and functional maturation in vivo, and predicting the long-term graft outcome already at the progenitor stage remains a challenge. Here, we took an unbiased approach to
This paper focuses on Nanluoguxiang (NLGX), a historic neighbourhood in Beijing, where the author lived for 2,5 years. The neighbourhood is one of 25 conservation areas in the city, and since 2008 a popular tourist attraction among both domestic and foreign tourists. The area has a long history and many well preserved buildings, including two smaller muse
We report results from experiments where we characterize the surface properties of soot particlesinteracting with high-pressure methane. We find considerable differences in behavior of the soot materialbetween static and dynamic pressure conditions that can be explained by multiscale correlations inthe dynamics, from the micro to macro of the porous fractal-like carbon matrix. The measurements wer
