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Transcription factor (TF) proteins regulate gene activity by binding to regulatory regions, most importantly at gene promoters. Many genes have alternative promoters (APs) bound by distinct TFs. The role of differential TF activity at APs during tumour development is poorly understood. Here we show, using deep RNA sequencing in 274 biopsies of benign prostate tissue, localized prostate tumours and

Abstrasct Entrepreneurial ecosystems as lenses promoting innovation and entrepreneurship have attracted substantial interest in research. However attention towards the role of sector-specific actors, such as healthcare-related organizations, within entrepreneurial ecosystems remains underexplored. This paper investigates how healthcare-related organizations are conceptualized within entrepreneuria

The impact of variations in the three-dimensional structure of the genome has been recognized, but solid cancer tissue studies are limited. Here, we performed integrated deep Hi-C sequencing with matched whole-genome sequencing, whole-genome bisulfite sequencing, 5-hydroxymethylcytosine (5hmC) sequencing and RNA sequencing across a cohort of 80 biopsy samples from patients with metastatic castrati

In primary Sjögren's disease (pSjD), there is a well-documented increased risk of hematological malignancies, particularly lymphomas, whereas studies examining the incidence of solid tumors have often yielded conflicting results. Data concerning the incidence of breast and gynecological cancers are similarly inconsistent. The aim of this study was to further investigate the incidence of these so-c

BACKGROUND: Prostate cancer is a heterogenous disease, but once it becomes metastatic it eventually becomes treatment resistant. One mechanism of resistance to AR-targeting therapy is lineage plasticity, where the tumor undergoes a transformation to an AR-indifferent phenotype, most studied in the context of neuroendocrine prostate cancer (NEPC). However, activation of additional de- or trans-diff

This thesis explores the goal conflicts and trade-offs that editors in the Canadian federal public service navigate as they work to ensure that government communications products meet the objectives of the Policy on Communications and Federal Identity. The research design, which is interpretivist in approach, draws on document analysis, analytic autoethnography, and phenomenological hermeneutics t

Denna uppsats undersöker hur dionysiskt vansinne, med utgångspunkt i det Nietzscheanska apolloniska-dionysiska, gestaltas i Den hemliga historien. Uppsatsen analyserar även hur Backanterna, såväl explicit som implicit, fungerar som en intertext i Tartts roman och hur pjäsen påverkar romanens händelseutveckling.

Documented performance featuring spherical amplification.PHACE Series 2023/24 #1Wiener Konzertsaal, Berio-Saal, Wien (AT)Ensemble Phace09/01/2024From the program:Romitelli, Fausto (1963-2004, IT) – Professor Bad Trip (for ensemble and electronics) [1998-2000]

För otränade öron och ögon är det inte lätt att se vad operasång och attofysik har med varandra att göra. I det här bidraget visar dock Johan Mauritsson och Hedvig Jalhed att det finns påtagliga paralleller. Artikeln är en frukt av ett populärvetenskapligt projekt där artikelförfattarna använder just dessa beröringspunkter för att sprida såväl visdom som skönhet för både öron och ögon.

The operation of instruments and detectors in laboratory or beamline environments presents a complex challenge, requiring stable operation of multiple concurrent devices, often controlled by separate hardware and software solutions. These environments frequently undergo modifications, such as the inclusion of different auxiliary devices depending on the experiment or facility, adding further compl

The androgen receptor (AR) is the central determinant of prostate tissue identity and differentiation, controlling normal, growth-suppressive prostate-specific gene expression 1 . It is also a key driver of prostate tumorigenesis, becoming "hijacked" to drive oncogenic transcription 2-5 . However, the regulatory elements determining the execution of the growth suppressive AR transcriptional progra

Extreme value theory has been receiving much attention of late for proactively estimating crash risk through a two-step procedure that first samples extreme traffic conflicts and then estimates crash risk based on those sampled extremes. Although the existing body of research has encapsulated sampling methods within a predominant conventional technique, there is no universally accepted practice on

UNLABELLED: Cancer cells exhibit phenotypical plasticity and epigenetic reprogramming, which allows them to evade lineage-dependent targeted treatments by adopting lineage plasticity. The underlying mechanisms by which cancer cells exploit the epigenetic regulatory machinery to acquire lineage plasticity and therapy resistance remain poorly understood. We identified Zinc Finger Protein 397 (ZNF397

This paper examines the practice of signposting in online counselling provided by the social services in Sweden. Specifically, it focuses on cases where online users are steered to seek offline help. The data corpus consists of 68 online chat logs (quasi-synchronous interactions) and 200 Internet question form exchanges (asynchronous interactions). The data were examined using the approach of conv

Pea albumins are the soluble fraction of pea proteins, recovered as a side stream of the isoelectric precipitation. The time-resolved heat-induced structural transitions of the whole fraction of pea albumin (PA) were studied by evaluating the structure of the two main fractions, PA1 and PA2. Synchrotron radiation circular dichroism (SR-CD) spectroscopy showed that the secondary structure signature

We have generated two reporter plasmids that either monitor expression of human papillomavirus type 16 (HPV16) E2 mRNAs using splice site SA2709 or HPV16 E1C mRNAs utilizing splice site SA2582. In plasmid pE2sLuc, the entire E2 open reading frame was replaced by the secreted luciferase (sLuc) reporter gene and in the pE1nLuc plasmid the E1/E1C open reading frame was fused in frame with the nanoluc

Swedish small-scale fishing has undergone significant changes over time. There are examples of small-scale fishers who have diversified their activities by developing new sales channels or by processing a large part of their products themselves. However, this type of activity is significantly less well-documented than the fishing itself. In this paper, we examine how the catches of the Swedish sma

BACKGROUND: Prostate cancers featuring an expansile cribriform (EC) pattern are associated with worse clinical outcomes following radical prostatectomy (RP). However, studies of the genomic characteristics of Gleason pattern 4 subtypes are limited.OBJECTIVE: To explore transcriptomic characteristics and heterogeneity within Gleason pattern 4 subtypes (fused/poorly formed, glomeruloid, small cribri