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Background: The role of cystectomy in synchronous oligometastatic bladder cancer is unclear. Objective: To describe a population-based consecutive cohort with primary oligometastatic bladder cancer (M1a or M1b) treated with curative intent. Methods: Twenty consecutive patients with primary stage M1a or M1b bladder cancer subjected to induction chemotherapy and radical cystectomy 2013–2024 in the S
Drawing upon meticulous ethnographic analysis and unique data sources, this book dissects the multifaceted challenges and occasional victories encountered by both educators and detained youth in Sweden. Originally published in Swedish, this book provides fresh insights into a crucial aspect of youth care and education. Theoretical underpinnings draw from ethnomethodology’s focus on members’ accoun
OBJECTIVE: To synthesise evidence related to the dissemination and implementation (D&I) of injury prevention interventions for female, woman and/or girl (female/woman/girl) athletes.DESIGN: Scoping review.DATA SOURCES: MEDLINE, APA PsycInfo, Cochrane Databases for Systematic Review, Cochrane Central Register for Controlled Trials Registry, EMBASE, CINAHL, SPORTDiscus, ERIC, ProQuest Dissertati
BackgroundAmyloid-β peptides (Aβ) applied to Alzheimer's disease (AD) brain bind to amyloid plaques (APs) and this binding is saturable. Meanwhile, anti-immunoglobulin G (IgG) antibodies label APs. Considering the saturable binding of Aβ to APs and the localization of IgGs in APs, specific binding proteins (BPs) for the applied Aβ could be anti-Aβ IgG antibodies (anti-AβAbs) in APs.ObjectiveOur ob
The maximum drawdown of a stochastic process is the largest peak-to-troughdecline observed over a given horizon [0, T]. Using arguments from extremevalue theory, we derive the limiting distribution of the maximum drawdown fora Brownian motion with positive drift as T → ∞. We show that, after suitablecentering and scaling, the maximum drawdown converges in distribution to theGumbel law.
IntroductionEquitable access to maternal and reproductive health (MRH) services remains a major challenge in low- and lower-middle-income countries (LLMICs), including Zambia. Despite health system reforms such as the National Health Insurance Scheme (NHIS) and family planning (FP) communication strategies, disparities persist, particularly among socioeconomically disadvantaged populations. This t
Background: In 2015, a proton therapy (PT) facility was established in Sweden with one aim being to ensure access for all children expected to benefit from PT. Despite potential dosimetric advantages and full subsidisation, PT is not always selected. This study explores reasons for choosing alternative radiotherapy (RT) modalities in a paediatric population. Material and methods: RT courses delive
Background: Allergic contact dermatitis (ACD) caused by isothiazolinones is a growing concern, particularly in consumer products. Octylisothiazolinone (OIT) is a potent sensitiser and commonly used as a preservative in rubbers, plastics and coatings, including those found in headphones. Despite increasing regulations on isothiazolinones in cosmetics, their presence in wearable devices remains unde
It has been a century since the birth of philosopher Gilles Deleuze (1925-95). At his friend’s expense, Michel Foucault once joked, saying that un jour ce siecle sera peut-etre deleuzien: “perhaps one day this century will be known as Deleuzian?” Is there truth to the notion that the present moment expresses something of a “Deleuzian aeon” for the humanities, and what are its ramifications for bib
A multi-variable adaptive controller is derived as the explicit solution to a minimax dynamic game. The minimizing player selects the control action as a function of past state measurements and inputs. The maximizing player selects disturbances and model parameters for the underlying linear time-invariant dynamics. This leads to a Bellman equation that can be solved explicitly for the case with un
The problem of approximate joint eigen-decomposition of a collection of matrices arises in a number of diverse engineering and signal processing problems. This problem is usually cast as an optimization problem, and it is the main goal of this publication to provide a theoretical study of the corresponding objective-functional. As our main result, we prove that this functional tends to infinity in
With the publication of Fossil Capital in 2016, Andreas Malm reshaped how scholars understand the relationship between capitalism and fossil fuels. Energy humanities scholars Caleb Wellum and Imre Szeman interviewed Malm in November 2024 about the arguments and impact of Fossil Capital, the development of his thought in several subsequent books, and the shifting landscape of climate politics. At a
Study objectives: The impact of rapid eye movement (REM) sleep duration on long-term adherence to continuous positive airway pressure (CPAP) therapy in patients with obstructive sleep apnea (OSA) is unclear. This study aimed to assess the characteristics of individuals with short REM sleep and investigate whether reduced REM sleep is associated with lower CPAP adherence over a two-year period in t
Dopamine and serotonin are two major monoamine neurotransmitters associated with Parkinson's disease (PD), but their spatial distribution and relationship to underlying functional brain architecture are not fully understood. We assessed 30 patients with PD at baseline using structural MRI, resting-state functional MRI (rs-fMRI), 11C-PE2I and 11C-DASB PET, along with comprehensive clinical evaluati
This study explores how higher music education institutions position themselves in relation to wider social and political forces and the expanding professional responsibilities of musicians in increasingly complex Nordic societies, which in this study includes Finland, Sweden, Norway and Denmark. By asking how the political—including various local and global social-ecological values, relations and
Background: Although there is substantial evidence of the negative impact of caffeine use on sleep quality, few studies focus specifically on adolescents’ patterns of use. This study aimed to identify patterns of caffeine use among adolescents and analyze their association with sleep quality. Method: A cross-sectional study was conducted in southern Sweden including 1,404 adolescents aged 15–17 (5
We introduce Thalassa, a framework designed to convert nonlinear systems of partial differential equations (PDEs) with a time-like component into tensor programs that solve these equations. These programs can run on GPUs as well as machine learning (ML) acceleration hardware, enabling scientific computing fields such as computational fluid dynamics, astrophysics, mechanics and biology to utilize a
Objective: The objective of this study was to determine the predictive value of amyloid-positron emission tomography (PET) versus the plasma ratio of phosphorylated tau at threonine 217 (p-tau217) to non-phosphorylated tau217 (%p-tau217) for tau-PET transitions (T− to T+). The added value of combining plasma amyloid-β 42 and amyloid-β 40 (Aβ42/40) and %p-tau217 into an amyloid probability score (A
