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The influence of charge and aromatic stacking interactions on the self-assembly of a series of four model amyloid peptides has been examined. The four model peptides are based on the KLVFF motif from the amyloid beta peptide, A beta(16-20) extended at the N terminus with two P-alanine residues. We have studied NH2-beta A beta AKLVFF-COOH (FF), NH2-beta A beta AKLVF-COOH (F), CH3CONH-beta A beta AK
Neutrophil-mediated lung injury is an insidious feature in sepsis although the mechanisms regulating pulmonary recruitment of neutrophils remain elusive. Here, we investigated the role of P-selectin glycoprotein-ligand-1 (PSGL-1) in sepsis-induced neutrophil recruitment and tissue injury in the lung. Bronchoalveolar infiltration of neutrophils, levels of myeloperoxidase, oedema formation and CXC c
Introduction: Elderly patients often use many drugs, increasing the risk for drug-related problems. Aim: To optimise drug therapy in the elderly by identifying, resolving and preventing drug-related problems. Methods: (Paper I) Medication reviews were conducted on nursing home patients’ with epilepsy or Parkinson’s disease by a multi-speciality team, whom identified drug-related problems and whe
A theory of self-induced transparency for a TM-mode propagating in a planar semiconductor waveguide sandwiched between two dielectric media is developed. A transition layer between the waveguide and one of the connected media is described using a model of a two-dimensional sheet of quantum dots. Explicit analytical expressions for the optical soliton in the presence of single-excitonic and biexcit
Costimulation blockade can prevent rejection of nerve allografts in short-term studies. We tested if costimulation blockade also prevented rejection of nerve allografts in long-term experiments, thereby improving functional recovery. A 7-mm sciatic nerve defect in C57/BL6 mice was bridged either by nerve allografts from Balb/C mice or by isogenic nerve grafts (isografts) from C57/BL6 mice. Costimu
Surgically revised deep infected primary knee arthroplasties reported to the Swedish knee arthroplasty register during the years 1986-2000 were studied with respect to microbiology, antimicrobial susceptibility pattern and changes over time. In early, delayed and late infections, coagulase-negative staphylococci (CoNS) were most prevalent (105/299, 35.1%), and twice as common as Staphylococcus aur
In social cognitive theory, self‐efficacy is domain‐specific. An alternative model, the cross‐domain influence model, would predict that self‐efficacy beliefs in one domain might influence performance in other domains. Research has also found that children who receive special instruction are not good at estimating their performance. The aim was to test two models of how self‐efficacy beliefs influ
Plasma fibrinogen concentration is important for coagulopathy assessment, and is most commonly measured using the Clauss method. Several factors, including device type and reagent, have been shown to affect results, The study objective was to evaluate performance and repeatability of the Clauss method and to assess differences between measurements performed during and after cardiopulmonary bypass
Abstract in UndeterminedIn this paper, the problem of jointly estimating the number of harmonics and the fundamental frequency of periodic signals is considered. We show how this problem can be solved using a number of methods that either are or can be interpreted as filtering methods in combination with a statistical model selection criterion. The methods in question are the classical comb filter
Objective: By retarding fat digestion, thylakoids, the internal photosynthetic membrane system of green plants, promote the release of satiety hormones. This study examined the effect of consuming a single dose of concentrated extract of thylakoids from spinach on satiety, food intake, lipids, and glucose compared to a placebo. Design: Sixty overweight and obese individuals enrolled in a double-bl
Human a-lactalbumin made lethal to tumor cells (HAMLET) and its analogs are partially unfolded protein-oleic acid (OA) complexes that exhibit selective tumoricidal activity normally absent in the native protein itself. To understand the nature of the interaction between protein and OA moieties, charge-specific chemical modifications of lysine side chains involving citraconylation, acetylation, and
The dependence of the rate of proton-proton interactions on the centre-of-mass collision energy, root s, is of fundamental importance for both hadron collider physics and particle astrophysics. The dependence cannot yet be calculated from first principles; therefore, experimental measurements are needed. Here we present the first measurement of the inelastic proton-proton interaction cross-section
The purpose of this review is to give the reader a thorough background to the fundamentals and applications of pressurized hot water extraction (PHWE) for the analysis of bioactive compounds. We summarize the field in the period 2009-14, and include fundamentals of water as a solvent: equipment; method optimization; applications; coupling; and, future prospects. We highlight that solvent propertie
Purpose - The purpose of this article is to question whether business is ethical as long as it follows rules, and on this view, to reflect over the relation between responsibility and justice. Design/methodology/approach - To exemplify this relation, the paper is based on in-depth interviews with a human rights consultant. In this way, the paper presents a story from the field and thus follows a n
Herbivores are known to decrease plant species diversity in ecosystems with low productivity. Limestone pavements are low-productive habitats harboring specialized communities of cyanobacteria, and endo- and epilithic lichens exposed to extreme temperature and humidity fluctuations. Pavements of the Great Alvar (O¨ land, Sweden) are covered by free-living cyanobacteria giving the rock surface a da
Climate change modelers predict increasingly frequent "extreme events," so it is critical to quantify whether organismal responses (such as reproductive output) measured over the range of usual climatic conditions can predict responses under more extreme conditions. In a 20-year field study on water pythons (Liasis fuscus), we quantified the effects of climatically driven annual variation in food
