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Defective silencing of retrotransposable elements has been linked to inflammageing, cancer and autoimmune diseases. However, the underlying mechanisms are only partially understood. Here we implicate the histone H3.3 chaperone Daxx, a retrotransposable element repressor inactivated in myeloid leukaemia and other neoplasms, in protection from inflammatory disease. Loss of Daxx alters the chromatin
Purpose: This paper aims to review total quality management (TQM) literature in the past three decades to identify the quality related key terms, to analyse their linkage among the identified key terms and their developmental trends. Design/methodology/approach: Bibliometric and statistical methods are used to analyse article titles published in the Total Quality and Business Excellence journal du
Background: Patients undergoing lumbar discectomy usually suffer from moderate to severe pain during the postoperative period. Multimodal, or balanced analgesia, is the leading treatment principle for managing postoperative pain. The rationale is to achieve optimal pain treatment through additive or synergistic effects of several non-opioid analgesics, and thereby, reducing the need for postoperat
Introduction: The evidence for characteristics of persons with subjective cognitive decline (SCD) associated with amyloid positivity is limited. Methods: In 1640 persons with SCD from 20 Amyloid Biomarker Study cohort, we investigated the associations of SCD-specific characteristics (informant confirmation, domain-specific complaints, concerns, feelings of worse performance) demographics, setting,
Breathlessness is common in the general population. Existing data were obtained primarily with the uni-dimensional modified Medical Research Council breathlessness scale (mMRC) that does not assess intensities of unpleasantness nor physical, emotional and affective dimensions. The aim of this research was to determine the prevalence and intensity of these dimensions of breathlessness in elderly ma
Background: Flow cytometry (FCM) aids the diagnosis and prognostic stratification of patients with suspected or confirmed myelodysplastic syndrome (MDS). Over the past few years, significant progress has been made in the FCM field concerning technical issues (including software and hardware) and pre-analytical procedures. Methods: Recommendations are made based on the data and expert discussions g
Den demografiska utvecklingen innebär att vi lever längre och den äldre befolkningen ökar samtidigt som personer i arbetsför ålder blir färre. Det innebär en ökad press på socialförsäkringssystemet när en större andel av befolkningen kommer att leva fler år som pensionär samtidigt som en allt mindre ande arbetar och bidrar med skattemedel. Det innebär att vi måste arbeta längre och därför höjs nu
Inhomogeneous magnetic transfer (ihMT) is more sensitive to myelin macromolecules than standard MT proxies. Measuring ihMT in the multi-parameter mapping protocol allows calculating ihMT from MT saturation (MTsat) maps and thus inherently correct for the undesired dependencies on flip angle and the longitudinal relaxation rate. Further validation of this new ihMT metric requires measurement of MPM
Accuracy in MP2RAGE-based T1-mapping relies on knowledge of the imperfect inversion efficiency (finv) of the inversion pulse. Here we map the inversion efficiency of different adiabatic inversion pulses in human brain at 7T. We identified a mean finv=0.86, which is substantially lower than the finv=0.96 typically assumed in MP2RAGE. We further observed a lower finv in white matter (WM) than in the
Background and Purpose: Cerebral tissue oxygenation is a critical brain viability parameter, and the magnetic properties of hemoglobin offer the opportunity to noninvasively quantify oxygen extraction fraction (OEF) by magnetic resonance imaging (MRI). Ultrahigh-field MRI shows advantages such as increased sensitivity to magnetic susceptibility differences and improved signal-to-noise ratio that c
There is a widespread perception that present-day Nordic egalitarianism is the outcome of a long historical continuity, where the strong political position of peasant farmers and weak feudalism were marking characteristics of pre-industrial society. However, little empirical evidence so far exists on the distribution of income for the early modern period. In this paper, we draw on the schedule an
