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The minimal U(1)B−L extension of the Standard Model (B-L-SM) offers an explanation for neutrino mass generation via a seesaw mechanism; it also offers two new physics states, namely an extra Higgs boson and a new Z′ gauge boson. The emergence of a second Higgs particle as well as a new Z′ gauge boson, both linked to the breaking of a local U(1)B−L symmetry, makes the B-L-SM rather constrained by d
Fundamental chemistry in heterogeneous catalysis is increasingly explored using operando techniques in order to address the pressure gap between ultrahigh vacuum studies and practical operating pressures. Because most operando experiments focus on the surface and surface-bound species, there is a knowledge gap of the near-surface gas phase and the fundamental information the properties of this reg
Sustainable housing that both creates good indoor environmental quality (IEQ) and avoids unnecessary energy use has proved difficult to realize. Renovations of multifamily houses provide an opportunity to find this balance. This study concerns whether tenants perceive that conditions for achieving sufficient IEQ with low energy use exist. Focus group interviews with 42 participants, in areas where
Summary: Romosozumab is a novel bone-building drug that reduces fracture risk. This health economic analysis indicates that sequential romosozumab-to-alendronate can be a cost-effective treatment option for postmenopausal women with severe osteoporosis at high risk of fracture. Purpose: To estimate the cost-effectiveness of sequential treatment with romosozumab followed by alendronate (“romosozuma
Combining forecasts from multiple temporal aggregation levels exploits information differences and mitigates model uncertainty, while reconciliation ensures a unified prediction that supports aligned decisions at different horizons. It can be challenging to estimate the full cross-covariance matrix for a temporal hierarchy, which can easily be of very large dimension, yet it is difficult to know a
The 2016 Kumamoto earthquake had a significant impact on groundwater levels and quality. In some areas, the groundwater level increased significantly due to the release of groundwater from upstream mountainous regions. Conversely, the groundwater level in other areas greatly decreased due to the creation of new fracture networks by the earthquake. There were also significant changes in certain gro
The success of left ventricular assist device (LVAD) therapy is hampered by complications such as thrombosis and bleeding. Understanding blood flow interactions between the heart and the LVAD might help optimize treatment and decrease complication rates. We hypothesized that LVADs modify shear stresses and blood transit in the left ventricle (LV) by changing flow patterns and that these changes ca
As for the automotive industry, industry and academia are making extensive efforts to create autonomous ships. The solutions for this are very technology-intense. Many building blocks, often relying on AI technology, need to work together to create a complete system that is safe and reliable to use. Even when the ships are fully unmanned, humans are still foreseen to guide the ships when unknown s
CONTEXT: Pancreatic beta-cell glucose sensitivity is the slope of the plasma glucose-insulin secretion relationship and is a key predictor of deteriorating glucose tolerance and development of type 2 diabetes. However, there are no large-scale studies looking at the genetic determinants of beta-cell glucose sensitivity. OBJECTIVE: To understand the genetic determinants of pancreatic beta-cell gluc
Industry Foundation Classes (IFC), the buildingSMART open standard for BIM, is underused with respect to its promising potential, since, according to the experience of practitioners and researchers working with BIM, issues in the standard’s implementation and use prevent its effective use. Nevertheless, a systematic investigation of these issues has never been carried out, and there is thus insuff
Many cell functions rely on the ability of microtubules to self-organize as complex networks. In plants, cortical microtubules are essential to determine cell shape as they guide the deposition of cellulose microfibrils, and thus control mechanical anisotropy in the cell wall. Here we analyze how, in turn, cell shape may influence microtubule behavior. Using a computational model of microtubules e
The plant shoot apical meristem holds a stem cell niche from which all aerial organs originate. Using a computational approach we show that a mixture of monomers and heterodimers of the transcription factors WUSCHEL and HAIRY MERISTEM is sufficient to pattern the stem cell niche, and predict that immobile heterodimers form a regulatory ‘pocket’ surrounding the stem cells. The model achieves to rep
Processes in individual and mass production are governed by certain principles which need to be taken into account as early as the conceptual design phase. A comprehensive analysis of processes in tool production has shown that production also needs to be considered in remodeling or the introduction ofconcurrent engineering. The paper discusses the principles of the manufacturing process which aff
Many small companies ask themselves how and when to begin participating in the information revolution, and what changes this may bring to their business operation. Five typical models of product data integration were designed to help users to create a comprehensive view of the problems of technical information systems in companies. It was found that setting up an information system is a dynamic pr
