Search results

Background: ST-segment elevation myocardial infarction (STEMI) is treated with stenting, but the underlying stenosis is often not severe, and stenting may potentially be omitted. Aims: The aim of the study was to investigate outcomes of patients with STEMI treated with percutaneous coronary intervention (PCI) without stenting. Methods: Patients were identified through the DANAMI-3-DEFER study. Ste

Introduction: Functional abdominal pain disorders (FAPDs) are common among girls and has been associated with stress. Cortisol is one of the major stress hormones. Dance and yoga have been shown to reduce abdominal pain among girls with FAPDs. Aim: To investigate the effect of an 8-month intervention with dance and yoga on cortisol levels in saliva among girls with FAPDs. Methods: A total of 121 g

In many ways, the European Union (EU) may be considered a unique foreign policy actor, combining a peculiar institutional design and set of resources with a specific normative agenda for and ambition in global affairs. Through a two-stage analysis, this chapter examines the role self-conception of the EU as it appears from the EU Global Strategy, released in 2016 as the overarching guide for forei

Tensor-valued diffusion encoding facilitates data analysis by q-space trajectory imaging. By modeling the diffusion signal of heterogeneous tissues with a diffusion tensor distribution (DTD) and modulating the encoding tensor shape, this novel approach allows disentangling variations in diffusivity from microscopic anisotropy, orientation dispersion, and mixtures of multiple isotropic diffusivitie

PURPOSESelumetinib can increase radioactive iodine (RAI) avidity in RAI-refractory tumors. We investigated whether selumetinib plus adjuvant RAI improves complete remission (CR) rates in patients with differentiated thyroid cancer (DTC) at high risk of primary treatment failure versus RAI alone.METHODSASTRA (ClinicalTrials.gov identifier: NCT01843062) is an international, phase III, randomized, pl

Årets Arena Idé-rapport om den svenska modellen och organisations-graden hos fack, arbetsgivare och a-kassor innehåller de senaste medlemsuppgifterna för samtliga fackförbund inklusive förbunden utanför LO, TCO och Saco. Det gäller antalet yrkesaktiva medlemmar vid årsskiftet 2024/2025. Även medlemsutvecklingen i PTK och OFR redovisas avseende de medlemmar som räknas till respektive förhandlingsor

Recently, it has become a focus to reduce non-exhaust aerosol emissions from the transport sector. One possible way to decrease brake particle emissions is by laser-cladding coatings onto brake discs. This work tested five different laser-cladding coated brake discs against a non-asbestos organic brake pad. The performance of these coatings was compared to a commercial grey cast iron brake disc te

Introduction: Severe asthma is a heterogeneous condition characterized bydistinct phenotypes and endotypes based on clinical or biologicalcharacteristics. Interleukin (IL) 4 and IL-13 are central cytokines in the type 2(T2) immune response, crucial for T2 inflammation. Biologic therapiestargeting the IL-4/IL-13 pathway, such as anti-IL-4Rα monoclonal antibodies(mAbs), have shown improvements in luIntroduction: Severe asthma is a heterogeneous condition characterized by distinct phenotypes and endotypes based on clinical or biological characteristics. Interleukin (IL) 4 and IL-13 are central cytokines in the type 2 (T2) immune response, crucial for T2 inflammation. Biologic therapies targeting the IL-4/IL-13 pathway, such as anti-IL-4Rα monoclonal antibodies (mAbs), have shown improvements

Background Anti-interleukin (IL)-4Rα monoclonal antibodies (mAb) improve lung function and decreasethe number of exacerbations in patients with COPD type (T) 2 inflammation. However, the involvement ofearly innate immune responses underlying these treatment effects is not well known. We sought tounderstand the effect and mechanisms of IL-4Rα mAb treatment on bronchial epithelial cells (BECs) fromCBackgroundAnti-IL-4Rα monoclonal antibodies (mAb) improve lung function and decrease the number of exacerbations in patients with COPD type (T) 2 inflammation. However, the involvement of early innate immune responses underlying these treatment effects is not well known. We sought to understand the effect and mechanisms of IL-4Rα mAb treatment on bronchial epithelial cells from COPD patients under

Sleep disturbances are prevalent among elderly populations and are linked to various health complications. Understanding the underlying biological mechanisms contributing to sleep disorders is crucial for developing targeted interventions. In this study, we measured 355 plasma proteins in an elderly Japanese cohort (n=77) using a high-throughput proteomic platform. Additionally, we collected over

We developed an algorithm for the early screening of autism spectrum disorder using baby cry sound. We collected the sound using a smartphone application to record it in their daily life. We employed the Japanese version of the Modified Checklist for Autism in Toddlers (M-CHAT) for the evaluation of the autism spectrum. We built a prediction model for binary classification using least absolute shr

Background and AimsAdolescent mental health has declined in recent decades. Few studies have explored whether shifts in interpersonal behaviours– both in-person and online– can help explain this decline. Using data from two Swedish cohorts (2007–2008, 2023–2024), we examined (1) 15-year time trends (2007–2008 vs. 2023–2024) in interpersonal behaviours (victimization, aggression, prosocial behaviou

Background: Patients with relapsing remitting multiple sclerosis (RRMS) treated with the high-efficacy drugs natalizumab (NTZ) or rituximab (RTX) generally show no evidence of disease activity. Currently, there is no head-to-head comparison between NTZ and RTX of neurodegenerative and neuroinflammatory biomarkers in cerebrospinal fluid (CSF). Objectives: To compare CSF biomarkers in a stable RRMS