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This study evaluated the safety and tolerability of ocular RS1 adeno-associated virus (AAV8-RS1) gene augmentation therapy to the retina of participants with X-linked retinoschisis (XLRS). XLRS is a monogenic trait affecting only males, caused by mutations in the RS1 gene. Retinoschisin protein is secreted principally in the outer retina, and its absence results in retinal cavities, synaptic dysfu
Aim: The impact of BL11282, an imidazoline receptor (NISCH) agonist, on potentiation of glucose-stimulated insulin secretion (GSIS) from isolated human non-diabetic (ND) and type 2 diabetic (T2D) islets was investigated. Methods: Analysis of mRNA was performed by RNA-sequencing and qPCR. Insulin and cAMP by RIA and ELISA respectively. Results: RNA-sequencing data revealed that NISCH is highly expr
The application of conventional organic solvents has been essential in several steps of bioprocesses in order to achieve sufficient economic efficiency. The use of organic solvents is frequently used either to partly or fully replace water in the reaction medium or as a process aid for downstream separation. Nowadays, manufacturers are increasingly requested to avoid and substitute solvents with h
Hur kan man minska onödig detaljstyrning och formalism och öka handlingsutrymmet för medarbetare och första linjens chefer i offentligt finansierad verksamhet? I denna antologi föreslås ett ramverk som utvecklar befintlig forskning och har ambitionen att förklara hur tillitsbaserad styrning och ledning kan förstås och översättas till en fungerande praktik. Boken rymmer fem konceptuella kapitel och
PurposeThe purpose of this paper is to describe and analyze the foundation of higher education policies that have promoted entrepreneurship in Sweden since the mid-1990s.Design/methodology/approachTo do this, the authors use Bacchi’s (1999) “What’s the problem?” approach. A central assumption of which is that perceptions of a problem affect how its solution looks. Bacchi’s approach is described as
This paper presents new findings about the passive film formed on super duplex stainless steel in ambient air and corrosive environments, studied by synchrotron grazing-incidence X-ray diffraction (GIXRD). The passive film, formed in air, was seen to be a nano-crystalline mixed-oxide. Electrochemical polarisation to the passive region in aqueous 1 M NaCl at room temperature resulted in an increase
