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Artificial Intelligence (AI) technologies are increasingly researched and applied for medical knowledge discovery and to support or automate clinical decision-making. The aim of this thesis is to increase the knowledge on (1) how AI experts, radiologists, and standardizers make sense of AI, in the processes of medical AI development, clinical use and standardization, and (2) how this sensemaking c
The speedy advancement of digital technologies in the last decade has introduced new tools, workflows and stakeholders in diplomacy, creating significant information demands and a state of “digital stress”. To navigate these challenges, diplomats employ coping strategies that leverage their reflexivity and autonomy to manage demands, prioritize tasks, and mitigate overload. Beyond merely adapting
The objective of this study was to assess the feasibility of using a poly(vinylidene fluoride) (PVDF) membrane modified with cellulose/nanostructures as a separation technique for the removal of poly(vinyl alcohol)(PVA)/reactive dyes from synthetic textile wastewater. The goal was to recycle PVA/reactive dye yellow 145 for reuse in the industry while simultaneously reclaiming water for reuse. To a
This paper discusses the complicated environment for global science, which is becoming increasingly competitive as the world is moving closer towards multipolarity. We frame the situation as global science disorder. Key issues include geopolitical dynamics, equity, erosion of academic freedom, and rising authoritarianism. The changes significantly impact HEIs, which must navigate these changes whi
This white paper presents a comprehensive biobanking framework developed at the European Cancer Moonshot Lund Center that merges rigorous sample handling, advanced automation, and multi-omic analyses to accelerate precision oncology. Tumor and blood-based workflows, supported by automated fractionation systems and standardized protocols, ensure the collection of high-quality biospecimens suitable
Persistent bacterial airway infection is a hallmark feature of cystic fibrosis (CF). Achromobacter spp. are gram-negative rods that can cause persistent airway infection in people with CF (pwCF), but the knowledge of host immune responses to these bacteria is limited. The aim of this study was to investigate if patients develop antibodies against Achromobacter xylosoxidans, the most common Achromo
Memories link elements across event boundaries, integrating overlapping content experienced at different times and places. Such memory representations are thought to rely on memory integration mechanisms. The present study used multivariate pattern analysis (MVPA) of electroencephalographic (EEG) data to elucidate the temporal dynamics of integrative encoding memory processes. Memory integration w
Contextual shifts are crucial for episodic memory, setting event boundaries during event segmentation. While lab research provides insights, it often lacks the complexity of real-world experiences. We addressed this gap by examining perceptual and conceptual boundaries using virtual reality (VR). Participants acted as salespeople, interacting with customers in a VR environment. Spatial boundaries
BackgroundPresence of a prosthetic joint entails a life-long risk of haematogenous periprosthetic joint infection (hPJI) during bacteraemia. For bacteraemia with Staphylococcus aureus the hPJI frequency has been described to be up to 40% and for streptococci up to 20%, with large variation among reported frequencies.ObjectivesWe aimed to investigate the hPJI frequency from bacteraemia with virulen
Objectives: Cystic fibrosis hepato-biliary involvement (CFHBI) is a common comorbidity in patients with CF and is associated with increased morbidity and mortality. The effect of the new and highly potent CF transmembrane conductance regulator modulator therapy, elexacaftor-tezacaftor-ivacaftor (ETI), on CFHBI, is still unclear. This study aimed to investigate the impact of ETI on liver stiffness
Experiments using the surface force apparatus have found anomalously long-range interactions between charged surfaces in concentrated salt solutions. Ion clustering has been suggested as a possible origin of this behavior. In this work, we demonstrate that if such stable clusters indeed form, they are able to induce remarkably strong free energy barriers under conditions where a corresponding solu
In villages and cities across the Indonesian island of Java, hundreds of songbird competitions are held every week. In these competitions, members of one species of songbird compete each other, where the aesthetic qualities the song, including its rhythm, melody, timbre, and volume, are evaluated by a team of referees. First prizes are large cash awards and sometimes cars. Birdsong that incorporat
Serum Amyloid A (SAA) proteins are critical mediators of immune activation and metabolic regulation, bridging the acute-phase response with long-term disease dynamics. Once considered mere biomarkers of inflammation, emerging research has revealed their central role in orchestrating immune responses, lipid metabolism, and tissue remodeling. SAA proteins display context-dependent functions: they pr
»Music to me is… my work. I've landed in the best job in the world, where a core task is to discover new music, to learn its internal logic and aesthetics, who created it, and why. I'm a music researcher and have just returned from the island of Java in Indonesia with my research partner and husband Nils, where we've been visiting experimental musicians in Yogyakarta – artists we've now followed f
Swedish art and music schools (SAMS), established in the 1940s, aim to provide affordable extra-curricular instrumental and singing education for all children, regardless of their parents’ economic situation. The tuition is highly subsidized, with families contributing only about 7% of the tuition costs. While traditionally focusing on one-to-one instruction, a recent governmental report (2016) ha
In the present work, we describe the design, synthesis, and evaluation of a galectin-8- binding fluorescent probe designed for a competitive fluorescence polarization (FP) assay for screening new galectin-8N inhibitors. The probe was characterized for its photophysical properties and its binding affinity for galectin-8N was determined by using FP. We evaluated the probe in a competitive FP assay w
