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Background The nomenclature and execution of peritonectomy procedures for peritoneal surface malignancies significantly vary between surgeons and centres. The aim of this consensus was to reach uniform nomenclature for peritonectomy procedures, to define subregions of each peritonectomy procedure, and to define boundaries of each subregion. Methods The modified Delphi technique was employed. A gro
Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available. Clinical Trial Updates provide an opportunity to disseminate additional results from studies, published in JCO or elsewhere, for which the primary end point has
Introduction: Anal squamous cell carcinoma (ASCC) is primarily treated with chemoradiotherapy (CRT), but surgery can be curative following treatment failure. The treatment of ASCC was centralised in Sweden in 2017. This study aims to describe the characteristics and outcomes of surgery for ASCC nationally, focusing on short-term morbidity and mortality. Materials and Methods: All patients with ASC
Background: The increased prevalence of atopic diseases may be due to lifestyle changes affecting our exposure to microbes. We investigated the association between infections, fever, and atopic diseases in a large international birth cohort setting. Methods: 3842 children at genetic risk for type 1 diabetes were followed prospectively for the first 10 years for the occurrence of infections and ato
Aims Cardiac allograft vasculopathy (CAV) is a significant complication that contributes to both morbidity and mortality after heart transplantation. The aim of this study was to (i) assess if quantitative cardiovascular magnetic resonance (CMR) myocardial perfusion could detect different stages of CAV and (ii) establish a myocardial perfusion reserve (MPR) cut-off for significant CAV. Methods and
Solvers’ participation is essential for successful implementation of crowdsourcing contests for problem solving (CCPS). Many efforts have been made to investigate solvers’ various participation behaviours in CCPS. Whether or not a solver will conduct a behaviour is the result of decision making. However, to our knowledge, few studies concentrated on solvers’ participation from a decision process p
INTRODUCTION: Blood-based biomarkers (BBMs) have revolutionized Alzheimer's disease diagnosis and monitoring. Their pre-analytical stability requires scrutiny. This study assessed pre-analytical effects to inform a standardized sample handling protocol. METHODS: Assessed pre-analytical variations included collection tube type, hemolysis, centrifugation settings, centrifugation/storage delays, tube
Phosphorus-enhanced (P-rich; [P/Fe] ≳ +0.8) giants have been found among mildly metal-poor field stars, but in only one star in a globular cluster (GC), M4 (NGC 6121). Also, in a sample of bulge spheroid stars, some of them showed a moderate P enhancement in the range +0.5 < [P/Fe] < +1.0. In this paper we derive the P abundance of moderately metal-poor ([Fe/H] ≳ −1) GC stars, aiming to check if t
INTRODUCTION: Despite having few vascular risk factors, people with Down syndrome (DS) have MRI evidence of cerebrovascular disease (CVD) and neuroinflammation that worsens with Alzheimer's disease (AD) severity. We investigated whether markers of CVD and inflammation are associated with AD-related diagnostic progression in people with DS. METHODS: We included 149 participants (mean age [SD] = 44.
The PResymptomatic EValuation of Experimental or Novel Treatments for Alzheimer's Disease (PREVENT-AD) is an investigator-driven study that was created in 2011 and enrolled cognitively normal older adults with a family history of sporadic AD. Participants are deeply phenotyped and have now been followed annually for more than 12 years (median follow-up 8.0 years, SD 3.1). Multimodal magnetic reson
It is an open question whether small planets around M dwarfs are able to maintain atmospheres. The Hot Rocks Survey aims to address this question by observing nine rocky exoplanets orbiting M dwarfs with MIRI emission photometry to constrain the onset of atmospheres. In this paper, we present two MIRI F1500W (15 μm) eclipses of LTT 3780 b, an ultrashort-period super-Earth (P = 0.768 days, R = 1.32
Anthropogenic noise is an increasing form of environmental change that alters natural soundscapes. Human activities, including road traffic, have led to a notable increase in ambient noise, which may impair how animals use their sensory systems to fulfill vital activities. Previous experiments suggest that noise affects the hunting behavior of nocturnal predators, but it is still scarcely document
Since 1955, a form of diabetes in lean, young (BMI <18·5 kg/m2, age <30 years) individuals with a history suggestive of undernutrition from before birth and throughout childhood has been described in the literature. In 1985, WHO formally classified it as malnutrition-related diabetes, but subsequently removed the classification in 1999 over a disagreement as to whether undernutrition was a suffici
Dryland ecosystems are globally important, yet state-of-the-art dynamic vegetation models often lack specific processes or parameterizations that are critical for accurately simulating dryland dynamics. These missing processes include a realistic calculation of soil water movement, detailed plant–water relations, or a representation of deep water uptake. In this study, we show how including a proc
Introductions to data analysis in university physics often focus on fitting (typically to linearised functions) and uncertainty propagation, but residuals are less commonly introduced. Structured residuals indicate that the function (theoretical description) used to fit data does not capture all the relevant elements (i.e. the theoretical description is incomplete), and can be present even when th
Background Self-harm is a prevalent health concern among youths, with significant psychosocial impacts on both youths and their parents. The aim of this study is to describe the impact of offspring self-harm on parental work absence. Methods This cohort study included 176 472 mothers and 161833 fathers of 17 726 youths with a first self-harm diagnosis between the years of 2006 and 2016 and 177 260
Realistic representation of atmospheric aerosol size distribution dynamics in large-scale climate models is important for developing accurate descriptions of aerosol-cloud interactions. Despite the dynamic nature of the distributions, which have large seasonal and diurnal changes, model evaluations often focus on the annual median size distribution. Using more comprehensive monthly and diurnal mod
Melanoma remains the most aggressive form of skin cancer, characterized by high metastatic potential, genetic heterogeneity, and resistance to conventional therapies. The Melanoma MEGA-Study is a multi-center initiative designed to address these clinical challenges by integrating advanced proteogenomic profiling, clinical metadata, with AI-driven digital pathology and machine learning analytics, a
