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Background: By being highly involved in the tumor evolution and disease progression of small cell lung cancer (SCLC), Myc family members (C-Myc, L-Myc, and N-Myc) might represent promising targetable molecules. Our aim was to investigate the expression pattern and prognostic relevance of these oncogenic proteins in an international cohort of surgically resected SCLC tumors. Methods: Clinicopatholo

Axially heterostructured nanowires (NWs) constitute a promising platform for advanced electronic and optoelectronic nanodevices. The presence of different materials in these NWs introduces a mismatch resulting in complex strain distributions susceptible of changing the band gap and carrier mobility. The growth of these NWs presents challenges related to the reservoir effect in the catalysts drople

Background: Quantitative cardiovascular magnetic resonance (CMR) first pass perfusion maps are conventionally acquired with 3 short-axis (SAX) views (basal, mid, and apical) in every heartbeat (3SAX/1RR). Thus, a significant part of the left ventricle (LV) myocardium, including the apex, is not covered. The aims of this study were 1) to investigate if perfusion maps acquired with 3 short-axis view

Language development is a long-term process. Individual-level longitudinal case studies have been foundational to SLA. However, methodologies that can support person-focused and process-oriented research lack consolidation. Qualitative longitudinal (QL) research (Neale, 2021a, 2021b) is a methodology that facilitates exploration of the influences of time over time. It provides a temporal architect

Den här boken handlar om de lexikogrammatiska förutsättningarnaför välfungerande och rimligt lättillgängliga inhemska lagtexter ochöversatta EU-rättsakter och -domar. Bokens huvudtes är attspråkformen i bägge fallen måste grundas på skriftlighet, dvs. på ettkvalificerat bruk av hela det formella skriftspråketskonstruktionsregister och med strikt tillämpning av dess generellanormsystem. Boken vände

Sustaining yields for smallholder perennial agriculture under a rapidly changing climate regime may require consideration of landscape features and on-farm management decisions in tandem. Optimising landscape and management may not be possible for maximising yields in any one year but maintaining heterogeneous landscapes could be an important climate adaptation strategy. In this study, we observed

The construction of large hydro infrastructures often causes severe socio-environmental issues. When the facility is projected on transboundary rivers, such as the Nile, these issues may become political and involve a much greater number of actors. The Grand Ethiopian Renaissance Dam (GERD) is provoking significant geopolitical tensions in the Horn of Africa since it involves two of the most dynam

Quality enhancement projects in universities frequently rely on short-term, fragmented studies implemented in response to snapshot data linked to student feedback. Such projects may not address the complex interplay across stakeholder groups and do not always acknowledge the unintended consequences of change. This article, focused on systems design, draws on research conducted over seventeen years

As an inexpensive industrial chemical, chlorodifluoromethane (Freon-22), despite its relatively low reactivity, can serve as a practical CF2 source for the construction of gem-difluorinated ring structures. Here, we develop a protocol for the efficient assembly of valuable fluorinated 2,3-dihydrobenzofurans from the [4 + 1] annulation in good yields under basic conditions. The reliable practicabil

How do humans construct their mental representations of the passage of time? The universalist account claims that abstract concepts like time are universal across humans. In contrast, the linguistic relativity hypothesis holds that speakers of different languages represent duration differently. The precise impact of language on duration representation is, however, unknown. Here, we show that langu

Background: A pre-existing, well-established European influenza surveillance network known as I-MOVE enabled the rapid implementation of a European multi-country COVID-19 hospital surveillance network for surveillance of hospitalized COVID-19 cases in early 2020. This network included 257 hospitals in 11 surveillance sites across nine countries. We aimed to identify whether the surveillance object

The possibility of engineering artificial Kitaev chains in arrays of quantum dots coupled via narrow superconducting regions has emerged as an attractive way to overcome the disorder issues that complicate the realization and detection of topological superconducting phases in other platforms. Although a true topological phase would require long chains, a two-site chain realized in a double quantum

Patients who initially survive the rupture and repair of a brain aneurysm often take a devastating turn for the worse some days later and die or suffer permanent neurologic deficits. This catastrophic sequela is attributed to a delayed phase of global cerebral ischemia (DCI) following aneurysmal subarachnoid hemorrhage (aSAH), but we lack effective treatment. Here we present our view, based on 20

Considerable progress has been made in the field of leadership in recent years. However, we argue that this is undermined by a strong residual commitment to an older set of ideas which have been repeatedly debunked but which nevertheless resolutely refuse to die. These, we term zombie leadership. Zombie leadership lives on not because it has empirical support but because it flatters and appeals to

Comprehensive sexuality education (CSE) is seen as a key instrument through which to affect behaviour and improve sexual and reproductive health (SRH) outcomes amongst adolescents. However, few studies have to date evaluated key SRH outcomes following exposure to CSE within a school setting. This study estimates the association between CSE and HIV testing and HIV testing self-efficacy amongst HIV

OBJECTIVE: To describe midwives' experiences of intact cord resuscitation close to the mother for nonvigorous neonates after vaginal birth.DESIGN: Descriptive qualitative.SETTING: Four labor wards in Sweden.PARTICIPANTS: Midwives (N = 13) currently or previously employed in labor wards where the Sustained Cord Circulation and Ventilation (SAVE) study was conducted.METHODS: We analyzed semistructur