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Blood biomarkers indicative of Alzheimer’s disease (AD) pathology are altered in both preclinical and symptomatic stages of the disease. Distinctive biomarkers may be optimal for the identification of AD pathology or monitoring of disease progression. Blood biomarkers that correlate with changes in cognition and atrophy during the course of the disease could be used in clinical trials to identify

Objective: Previous work suggested that the ultrasound-based benign Simple Descriptors can reliably exclude malignancy in a large proportion of women presenting with an adnexal mass. We aim to validate a modified version of the Benign Simple Descriptors (BD), and we introduce a two-step strategy to estimate the risk of malignancy: if the BDs do not apply, the ADNEX model is used to estimate the ri

In this paper, we present a new account of teleological reasons, i.e. reasons to perform a particular action because of the outcomes it promotes. Our account gives the desired verdict in a number of difficult cases, including cases of overdetermination and non-threshold cases like Parfit’s famous Drops of water. The key to our account is to look more closely at the metaphysics of causation. Accord

Using heterogeneous photocatalysts for harvesting sunlight and converting it for water remediation and splitting are promising to mitigate the possible crisis of environment and energy. Among various composites, the MoS2-based heterostructures and Ni-based systems exhibit unique electronic, optical properties and redox capabilities, enabling their roles as photocatalysts. Herein, the impacts of ch

Aims/hypothesis: The rapid remission of type 2 diabetes by a diet very low in energy correlates with a marked improvement in glucose-stimulated insulin secretion (GSIS), emphasising the role of beta cell dysfunction in the early stages of the disease. In search of novel mechanisms of beta cell dysfunction after long-term exposure to mild to severe glucotoxic conditions, we extensively characterise

This contribution focuses on narratives and experiences of belonging and exclusion among convert members of Three Wheels, a Japanese Shin Buddhist temple in London, to investigate how difference is incorporated into transnational Buddhism. Three Wheels, whose members include both diasporic Japanese and convert Buddhist Europeans, occupies a marginal position within both transnational Shin Buddhism

Objective: To investigate long-term survival, neurologic outcome, and quality of life in patients with spontaneous supratentorial intracerebral hemorrhage (ICH) treated with craniotomy and hematoma evacuation. Methods: A nationwide multicenter retrospective analysis of 341 patients who underwent craniotomy and evacuation of supratentorial ICH between January 1, 2011, and December 31, 2015, was per

This article departs from the promise frequently put forward, that Social work is a profession committed to human rights. In a Swedish context, this commitment is manifested in ethical guidelines as well as national law referring to rights such as the right to ‘a reasonable living standard’. In recent years, politicized processes have allowed legislation guiding social work to interact deeply with

Aims: Use of left ventricular assist devices (LVADs) in older patients has increased, and assessing outcomes in older LVAD recipients is important. Therefore, this study aimed to investigate associations between age and outcomes after continuous-flow LVAD (cf-LVAD) implantation. Methods and results: Cf-LVAD patients from the multicentre European PCHF-VAD registry were included and categorized into

Mycket har sagts och skrivits om polarisering men sällan med några historiska tillbakablickar. Ibland kan det nästan framstå som att polarisering är ett helt nytt fenomen.I den här boken vänder åtta idéhistoriker på perspektivet och argumenterar för att företeelsen är lätt att finna även i det förgångna. Skribenterna ger oss inblickar i polariserade situationer och konflikter som

Introduction: In factor VIII (FVIII) prophylaxis for haemophilia A, cost comparisons have used price per international unit (IU) based on the once reasonable assumption of equivalent outcome per IU. Now, with several extended half-life (EHL) products available, new outcome-oriented ways to compare products are needed. Area under the curve (AUC) quantifies FVIII levels over time after infusion prov

This study examines the extent of the gap between the proportions of survey respondents reporting (1) having the possibility to use and (2) using special transport services (STS) compared to the corresponding gaps for other transport modes. For persons eligible for STS, differences between those who use them and those who do not use them are explored. The frequencies with which these two groups le

Individual plants can modify the microenvironment within their spatial neighborhood. However, the consequences of microenvironment modification for demography and species interactions remain unclear at the community scale. In a study of co-occurring alpine plants, we 1) determined the extent of species-specific microclimate modification by comparing temperature and soil moisture between vegetated

Background: Survivors of Hodgkin lymphoma (HL) are at risk of developing non-Hodgkin lymphoma (NHL) after treatment; however, the risks of developing subsequent primary lymphomas (SPLs), including HL and NHL, after different types of childhood cancer are unknown. The authors quantified the risk of SPLs using the largest cohort of childhood cancer survivors worldwide. Methods: The Pan-European Netw

Background: Detecting pancreatic cancer at an earlier stage may contribute to an increased survival. Patients with stage I pancreatic cancer have a 5-year survival rate of 36%, while stage IV patients have a 5-year survival rate of 1% in Sweden. Research into novel blood-based biomarkers for pancreatic cancer is highly intensive and innovative, but has yet to result in any routine screening test.