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The Finnish Gestational Diabetes (FinnGeDi) study is a multicentre study that considered Finnish women who gave birth in 2009–12, as well as their children and the children’s fathers. The study period was after the introduction of new Finnish national comprehensive screening guidelines for gestational diabetes mellitus (GDM). The study consisted of two arms: a prospective clinical, genetic case-co

https://www.lupop.lu.se/article/cohort-profile-finnish-gestational-diabetes-finngedi-study - 2025-10-03

Physical activity (PA) may improve brain development, cognition, concentration and academic performance. In this prospective controlled intervention study, we increased the level of PA in 338 children aged 6–8 years at study start, from the Swedish standard of 60 min per week to 200 min per week (40 min daily). The intervention continued in all nine compulsory school years until the students gradu

https://www.lupop.lu.se/article/daily-school-physical-activity-improves-academic-performance - 2025-10-03

The objective was to investigate associations between the General Health Questionnaire with twelve sub-items (GHQ-12) and prospective five-year suicide mortality. The two commonly used GHQ-12 cut-offs (2/3 and 3/4) were analyzed. METHOD:The 2008 public health survey, which was conducted in the autumn of 2008 in Scania, southern Sweden, is based on a postal questionnaire answered by 28,198 particip

https://www.lupop.lu.se/article/poor-psychological-health-and-5-year-suicide-mortality-population-based-prospective-cohort-study - 2025-10-03

Preeclampsia is one of the most common causes of perinatal and maternal morbidity/mortality. One suggested environmental risk factor is exposure to endocrine-disrupting pollutants such as per- and polyfluoroalkyl substances (PFAS). The present case-control study in southern Sweden aims to investigate the hypothesized association between serum concentrations of PFAS in early pregnancy and the risk

https://www.lupop.lu.se/article/and-polyfluoroalkyl-substances-early-pregnancy-and-risk-preeclampsia-case-control-study-southern - 2025-10-03

We aimed to evaluate the nationwide incidence and a potential increase in invasive infections with Fusobacterium necrophorum. Secondly, we aimed to describe epidemiology, clinical characteristics and outcomes for the different presentations: Lemierre's syndrome (LS), invasive head and neck-infection without LS and invasive non-head and neck-infection. Read more at https://www.sciencedirect.com/sci

https://www.lupop.lu.se/article/invasive-infections-fusobacterium-necrophorum-including-lemierres-syndrome-8-year-swedish-nationwide - 2025-10-03

Although colorectal cancer (CRC) screening guidelines acknowledge the need for earlier screening for high-risk individuals, such as those with family history of CRC, there is limited information on how many years earlier these high-risk individuals should be screened; current practice is based on weak evidence. We aimed to provide risk-adapted recommendations on the starting age of CRC screening f

https://www.lupop.lu.se/article/calculating-starting-age-screening-relatives-patients-colorectal-cancer-based-data-large-nationwide - 2025-10-03

Prenatal exposures may contribute to male infertility in adult life, but large-scale epidemiological evidence is still lacking. The Fetal Programming of Semen quality (FEPOS) cohort was founded to provide means to examine if fetal exposures can interfere with fetal reproductive development and ultimately lead to reduced semen quality and reproductive hormone imbalances in young adult men. Read mor

https://www.lupop.lu.se/article/fetal-programming-semen-quality-fepos-cohort-dnbc-male-offspring-cohort - 2025-10-03

We included adults aged 18 years and older in Sweden in first‐generation (n = 6 042 891) and second‐generation (n = 4 860 469) sub‐studies. MS was defined via two diagnoses in the Swedish National Patient Register. MS risk was estimated by Cox regression, with hazard ratios (HRs) and 95% confidence intervals (CI), in different immigrant groups, using Swedish‐born as referents in first‐generation s

https://www.lupop.lu.se/article/multiple-sclerosis-among-first-and-second-generation-immigrant-groups-sweden - 2025-10-03

While discontinuation of COPD maintenance medication is a known problem, the proportion of patients with discontinuation and its geographical and sociodemographic distribution are so far unknown in Sweden. Therefore, we analyse this question by applying an innovative approach called multilevel analysis of individual heterogeneity and discriminatory accuracy (MAIHDA). Read more at https://www.dovep

https://www.lupop.lu.se/article/geographical-and-sociodemographic-differences-discontinuation-medication-chronic-obstructive - 2025-10-03

During the last 4 decades, registration of patients with primary immunodeficiencies (PID) has played an essential role in different aspects of these diseases worldwide including epidemiological indexes, policymaking, quality controls of care/life, facilitation of genetic studies and clinical trials as well as improving our understanding about the natural history of the disease and the immune syste

https://www.lupop.lu.se/article/global-systematic-review-primary-immunodeficiency-registries - 2025-10-03

Research Services is pleased to announce a pair of webinars on research funding from some of the biggest funders in Sweden. These webinars will give you a chance to hear straight from the funders about their schemes and funding philosophy, and they will also answer your questions directly. The webinars are open to all researchers at Lund, and no prior knowledge of the funders or their schemes is r

https://www.lupop.lu.se/article/research-services-presents-meet-funders - 2025-10-03

Oesophagogastric cancers carry a high mortality, economic burden and rising incidence. There is a need to monitor and improve care for this disease. Pathologic information is a cornerstone of cancer diagnosis, treatment and prognosis. Few population-based studies combine pathology information and clinical outcomes. The objective of this study is to develop a clinical and pathological database of o

https://www.lupop.lu.se/article/population-registry-esophageal-and-stomach-tumours-ontario-presto-protocol-multicentre-clinical-and - 2025-10-03

Read more at https://moh-it.pure.elsevier.com/en/publications/the-italian-registry-for-primary-immunodeficiencies-italian-prima-2

https://www.lupop.lu.se/article/italian-registry-primary-immunodeficiencies-italian-primary-immunodeficiency-network-ipinet-twenty - 2025-10-03

Alpha-1 antitrypsin deficiency (AATD) is a rare and underdiagnosed disease that is associated with the development of liver disease in adults and children and pulmonary emphysema in adults. Several studies have shown that there is limited knowledge about the disease and its diagnosis among health care providers, and there is an important inequity in the access to specialized care and appropriate t

https://www.lupop.lu.se/article/importance-reference-centers-and-registries-rare-diseases-example-alpha-1-antitrypsin-deficiency - 2025-10-03

This study exploits policy reforms in Swedish primary care to examine the effect of pay-for-performance (P4P) on compliance with hypertension drug guidelines among public and private health care providers. Using provider-level outcome data for 2005–2013 from the Swedish Prescription Register, providers in regions using P4P were compared to providers in other regions in a difference-in-differences

https://www.lupop.lu.se/article/effects-pay-performance-prescription-hypertension-drugs-among-public-and-private-primary-care - 2025-10-03

Congenitally corrected and surgical atrial redirected transposition of the great arteries (TGA) represents states where the morphological right ventricle serves as a systemic ventricle (S-RV). The S-RV is prone to failure, but data on medical treatment on this problem is limited. The purpose of this study was to evaluate the survival in adults with S-RV, with or without heart failure treatment. De

https://www.lupop.lu.se/article/effect-medical-treatment-patients-systemic-right-ventricle - 2025-10-03

Diabetes mellitus (DM) and colorectal cancer (CRC) share some risk factors, including lifestyle and metabolic disturbances. We aimed to provide in-depth information on the association of CRC risk, especially early-onset CRC, with DM, family history of CRC, and age at DM diagnosis. Read more at https://journals.lww.com/ajg/Fulltext/2020/07000/Personal_History_of_Diabetes_as_Important_as.24.aspx

https://www.lupop.lu.se/article/personal-history-diabetes-important-family-history-colorectal-cancer-risk-colorectal-cancer - 2025-10-03

People with Parkinson’s disease (PD) have lower life satisfaction (LS) than healthy peers. No study has yet identified predictors of LS in people with PD. Such information would be valuable for health care and future interventions that aim to maintain or increase LS. Read more at https://www.hindawi.com/journals/pd/2020/1561037/

https://www.lupop.lu.se/article/prediction-life-satisfaction-people-parkinsons-disease - 2025-10-03

Eight new calls for proposal are now open The Swedish Research Council has now opened several calls for proposals within Natural and engineering sciences, Educational sciences and Development research. Most of the calls are open until 10 April, but the Network grant within Educational Sciences is open until 27 March.Read more at www.vr.se.

https://www.lupop.lu.se/article/new-calls-proposal-vr - 2025-10-03

Red blood cell (RBC) transfusions are associated with risks including immunological reactions and volume overload. Current guidelines suggest a restrictive transfusion strategy in most patients with sepsis but based on previous randomized controlled trials and observational studies, there are still uncertainties about the safety in giving low-grade RBC transfusions to patients with sepsis. Read mo

https://www.lupop.lu.se/article/mortality-and-morbidity-low-grade-red-blood-cell-transfusions-septic-patients-propensity-score - 2025-10-03