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Selective TDP-43 overexpression in oxytocin neurons in the paraventricular nucleus of the hypothalamus causes a decrease in oxytocin-immunopositive cells compared to uninjected mice. AAV-mediated TDP-43 overexpression in oxytocin neurons does not appear to be a major driver of behavioural and metabolic phenotypes in mice.
Background: The Swedish National Board of Health and Welfare centralized the surgical care of patients with anorectal malformations from four to two centres in 2018. This retrospective review compares short-term complications after anorectal reconstruction before and after centralization. Methods: Hospital records of all infants in Sweden who underwent reconstruction of an anorectal malformation b
Reader with texts by Hannah Arendt, selected by Gertrud Sandqvist
Controlled and sequence-selective DNA cleavage plays a crucial role in biomolecular engineering and nucleic acid technologies. Here, we report the development of cerium-coordinated catalytic hydrogel nanoparticles (Ce-CHNP) that exhibit single-strand-selective nuclease activity. Ce-CHNP was synthesized via a one-step polymerization process in which Ce(IV) coordinated with N-hydroxymethyl acrylamid
Purpose Gangliogliomas are highly epileptogenic tumors that are common in epilepsy surgery. The main aim of this study was to investigate whether the outcome of Anti-seizure medication (ASM) withdrawal differed between patients undergoing ganglioglioma surgery in an epilepsy surgery program compared with those who underwent surgery in other surgical programs. We also investigated which factors inf
Optical genome mapping (OGM) enables high-resolution detection of structural variants (SVs) and copy number aberrations (CNAs) using ultralong DNA molecules and minimal bioinformatics processing. Its diagnostic utility in solid tumors remains underexplored. Whole-genome sequencing (WGS) offers comprehensive variant detection but is resource intensive. This study presents a technical benchmarking o
Arthropod neurobiology has been studied overwhelmingly in insects, leaving the molecular basis of sensory systems in non-insect arthropods poorly understood; addressing this gap is necessary to enrich our knowledge of these understudied groups. Spiders possess sensory systems distinct from insects, with numerous synapses in peripheral sensory nerves, positioning them as an ideal model for investig
We combine existing perturbative results to show that a precise analytic determination of the charm-quark contribution to the hadronic light-by-light (HLbL) part of the muon anomalous magnetic moment is possible. Working in the MS‾ scheme, we include the NLO O(αs) correction, which significantly reduces the residual renormalization-scale dependence and the perturbative uncertainty. Our final resul
Unseen Sights: Magic, Modernity, and Childhood in Children’s Urban Fantasy explores and analyses the genre of children’s urban fantasy. Drawing upon a combination of fantasy, urban fantasy, and children’s literature scholarship, the thesis considers how children’s urban fantasy works – investigating both its forms and functions, and how it performs work in the world.The genre is analysed both sync
Objectives To examine the associations between socioeconomic position (SEP) and the incidence of serious hand infections—pyogenic flexor tenosynovitis (PFT) and septic arthritis (SA)—as well as risks of opioid overuse following diagnosis using nation-level data. Design In a registry-based nationwide retrospective cohort study, (1) associations between SEP and incidence of PFT/SA; (2) SEP and infec
BACKGROUND: Cardiovascular calcification is a significant predictor and contributor to cardiovascular diseases. Vascular smooth muscle cell (SMC)-derived extracellular vesicles (EVs) play a crucial role in microcalcification formation. EVs can originate from the endosomal system, and PIKFYVE (1-phosphatidylinositol 3-phosphate 5-kinase), a lipid kinase, plays a key role in endomembrane maturation.
Background There is a lack of contemporary data describing patients with left ventricular (LV) systolic dysfunction post myocardial infarction (MI) in terms of symptom burden and secondary prevention measures. The aim of this study was to describe patients with various degrees of LV systolic dysfunction after a first MI, their symptom burden, quality of life and adherence to recommended secondary
Visual assessment of medial temporal lobe atrophy (MTA) in the clinical workup of cognitive impairment is traditionally corrected for age since MTA increases with age. In addition, common pathologies in the elderly such as amyloid, tau, alpha-synuclein and TDP-43 accumulation as well as white matter hyperintensities representing small vessel disease may affect the association between MTA and age.
Introduction: Most centers treating patients with anorectal malformation (ARM) will screen for anomalies of the kidneys and urinary tract by using ultrasonography. There is no consensus on whether screening for vesico-ureteral reflux (VUR) should occur. To meet the diagnostic needs of ARM patients a method was developed to include a simultaneous VUR diagnosis and pre-reconstructive fistula work-up
The transformation of CO2 and green hydrogen into methanol presents a sustainable route for chemical and fuel production. Conventional methanol synthesis catalysts, such as Cu/ZnO/Al2O3, employ Al2O3 as a structural promoter, while Ga2O3 has recently emerged as a promising alternative. This study compares Cu-based catalysts supported on Al2O3 (CA) and Ga2O3 (CG), prepared via coprecipitation of la
Despite rapid advances in mapping genetic drivers and gene expression changes in hematopoietic stem cells (HSCs), few studies exist at the protein level. We perform a deep, multi-omics characterization (epigenome, transcriptome, and proteome) of HSCs in a mouse model carrying a loss-of-function mutation in Tet2, a driver of increased self-renewal in blood cancers. Using state-of-the-art, multiplex
