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Protein deletions are frequent among both natural and pathogenic variations. Many of them are misclassified in variation databases and the literature. Nonsense-mediated decay prevents the expression of many nucleotide deletions. Many variants classified as protein deletions are not expressed at all. We conducted an exhaustive systematic analysis of three types of deletions: N- and C-terminal delet

BackgroundWhile physical activity is known to affect the risk of MAFLD in adults, evidence in adolescents is limited and often based on self-reported questionnaires. We therefore used wearable device–based measurements to investigate the association between physical activity and MAFLD in adolescents.MethodsData were obtained from the National Health and Nutrition Examination Survey (NHANES) databa

Background: Although optical coherence tomography (OCT) has become essential in pediatric ophthalmology, normative data for children are lacking in most device databases. Due to ongoing ocular growth and developmental changes that occur during childhood and adolescence, adult reference values are not appropriate for pediatric use. Additionally, OCT measurements vary across devices, indicating the

This chapter introduces systematic reviews and provides a summary of systematic review methods. Because of the challenges in palliative care trials, systematic reviews might be even more relevant in palliative care than in many other areas of health care. This chapter highlights the reasons why a researcher should use a systematic review, as well as the instances when systematic reviews are not an

The Amazonian Craton is host to one of Earth’s largest Proterozoic silicic large igneous provinces (SLIPs), the Orocaima SLIP (ca. 1.98 Ga). Nevertheless, the mechanism(s) responsible for this large-flux felsic magmatic event and its relationships with regional tectonics and/or mantle processes remain debated. New geochronologic and geochemical results from multiple mafic dike swarms in the Amazon

I denna studie undersöks en vanlig fråga i utvecklingsländer - att informella arbetsrelationer kvarstår när den småskaliga gruvsektorn (ASM) ställs under statlig kontroll. Detta undersöks genom en studie av formaliseringsreformer i Rwandas 3Ts-sektor (tenn, tantal, volfram) för småskalig gruvdrift, som intensifierades från 2010. Forskningen syftar till att förklara den roll som arbetskraft, som båThis study explores a common issue in developing countries – the persistence of informal labour relations when the artisanal and small-scale mining (ASM) sector is brought under state control. It investigates this through a study of formalisation reforms in Rwanda’s 3Ts (tin, tantalum, tungsten) small-scale mining sector, which intensified from 2010. The research aims to explain the role that labo

Personer som självskadar har historiskt sett inte haft så mycket att säga till om i sina egna vårdprocesser. När de har sökt psykiatrisk vård akut, ofta för att de upplevt akut svåra tankar och impulser att skada sig själva och kanske har planerat göra suicidförsök, har personer som självskadar ofta blivit hemskickade utan hjälp, eller så har de blivit inlagda för långvarig psykiatrisk vård som faPeople who self-harm have historically not had much say in their healthcare processes. When seeking psychiatric emergency care, people who self-harm have frequently been turned away, or admitted for lengthy hospitalisations that may aggravate self-harm. The attitudes of psychiatric clinicians toward people who self-harm are important to healthcare users’ experience of care, affecting quality and a

Aims: In the randomized DAPA-MI clinical trial, 10 mg of dapagliflozin once daily improved cardiometabolic outcomes versus placebo after acute myocardial infarction (MI) in patients without established diabetes or heart failure (HF). We assessed associations between baseline left ventricular ejection fraction (LVEF) and cardiometabolic outcomes in DAPA-MI. Methods: The primary outcome, assessed us

Post-compression of (sub)-picosecond laser pulses down to sub-100 fs durations has become a standard approach for high-peak-power sources at a high average power [1]. Here, we propose a new post-compression geometry suited for extreme temporal compression of energetic narrowband lasers, such as diode or electrically pumped four-level systems which can deliver kW-average powers [2], but typically e

The projected increase in older people within the African population, alongside rapid urbanisation, points to the growing importance of understanding how older people navigate towns and cities across the continent. This aligns with wider concerns that geographical scholarship needs to pay more sustained attention to ageing in Global South contexts. Rather than treating these developments as proble

Three different semiconductor nanowires are combined into a single optoelectronic artificial neuron. Our device provides a path towards low power computations with significantly reduced circuit footprint, thus addressing critical limitations in neuromorphic photonics. The false-coloured scanning electron micrograph shown in Figure 1a depicts the fabricated nanowire neuron. Two pin-doped InP nanowi

Background and Objectives: The ease of hulling an oat genotype and the length of time the intact and hulled seeds can be stored viably without deteriorating quality has always been of interest to industry and farmers. We evaluated the hulling traits of different genotypes under varying growing conditions in 2018 and 2020, linking this to seed morphological and physiological features. Findings: We

A macroscopic constitutive model for the strain-induced martensite transformation observed in metastable austenitic stainless steels is presented. It models the material as an evolving two-phase austenite-martensite composite, where the plastic strains in each phase are computed using viscoplastic power-law relations. Two distinct hardening rules, one for austenite and the other for martensite, ar