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Prostate cancer bone metastasis is still not fully understood, and increased knowledge could aid in the development of better treatment options for patients in the future. This thesis focuses on microRNAs (miRNAs), which modulate gene expression in healthy and tumour cells. Using cell culture, animal and patient studies, we investigated the biological role of microRNA-96 (miR-96) and microRNA-379
The book comprises three parts: (1) a general presentation and analysis of the main relevant concepts: bioethics, human genetic engineering, eugenics, disability and, particularly, of the relations between these; (2) the analysis of two documents of the Council of Europe (the so called “Bioethics Convention” and its first protocol), and the reconstruction of the debates surrounding their primary c
Über sociale Differenzierung ist Georg Simmels erstes hauptsächlich der Soziologie gewidmetes Werk. Das Buch stellt Simmels Grundlegung der neuen Wissenschaft dar, ihrer Themen, Möglichkeiten, Grenzen, allgemeinen Begriffe und Annahmen. Soziale Differenzierung, Wechselwirkung, Individualisierung, Gruppe, Vergesellschaftung und Bewegung sind entscheidende, variable Begriffe dieses zwischen Grundleg
A heterocyclic chemical compound of formula (1) or (2) or a neutral or acidic salt thereof where the counter ion is LI+, Na+, K+, Mg2+, Ca2+, NH4+ or another pharmacologically acceptable positively charged inorganic or organic ion or any combination thereof. The compound contains B, Si, N, P, S or Se in the ring structure.
A search is presented for direct pair production of the stop, the supersymmetric partner of the top quark, in a decay through an Formula Presented-parity violating coupling to a charged lepton and a Formula Presented-quark. The dataset corresponds to an integrated luminosity of Formula Presented of proton-proton collisions at a center-of-mass energy of Formula Presented collected between 2015 and
China is now undergoing a fast process of industrialization, with the industry sector playing an important role in the overall economy. Among the many economic areas in China, Yangtze River Delta (YRD) takes the lead. The macro economy development and energy use status quo of both China and YRD are depicted, the past and current situation of air pollution and GHGs emissions is presented, and detai
This study explored the utility of the impact response surface (IRS) approach for investigating model ensemble crop yield responses under a large range of changes in climate. IRSs of spring and winter wheat Triticum aestivum yields were constructed from a 26-member ensemble of process-based crop simulation models for sites in Finland, Germany and Spain across a latitudinal transect. The sensitivit
A search for the resonant production of a heavy scalar X decaying into a Higgs boson and a new lighter scalar S, through the process X → S(→bb¯)H(→γγ), where the two photons are consistent with the Higgs boson decay, is performed. The search is conducted using an integrated luminosity of 140 fb−1 of proton-proton collision data at a centre-of-mass energy of 13 TeV recorded with the ATLAS detector
BACKGROUND: Several radiological societies in Europe have so far spoken out in favor of MRI of the small intestine over CT, since MRI is said to provide more detailed image information. Due to the limited availability of MRI machines, long waiting times arise for many patients who clinically require small bowel imaging.OBJECTIVES: These circumstances guided our search for an improved CT technique
A search for a new Z′ gauge boson predicted by Lµ-Lτ models, based on charged-current Drell-Yan production, pp→W±(∗)→Z′μ±ν→μ±μ μ±ν, is presented. The data sample used corresponds to an integrated luminosity of 140 fb-1 of proton-proton collisions at s=13 TeV recorded by the ATLAS detector at the Large Hadron Collider. The search examines a final state of 3μ plus large missing transverse momentum.
BackgroundShock is a condition with high mortality even with early intervention and treatment. Usual care for shock and hypotension in the Emergency Department (ED) is intravenous fluid resuscitation which can lead to fluid overload and other complications. When fluid therapy fails or risk of complications are high, the next treatment step is the use of vasopressors for stabilisation. Noradrenalin
Understreckare om Gunnar Wetterbergs bok "Byggarna"
BACKGROUND: The management of femoral neck fractures (FNF) in elderly patients depends on comorbidities, pre-fracture mobility, any hip joint disease, and life expectancy, with treatment typically involving either hemiarthroplasty (HA) or total hip arthroplasty (THA). While cemented femoral stem fixation is standard, there is no clear consensus regarding cemented versus cementless cup fixation in
