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Alzheimer’s disease (AD) is a heterogeneous neurodegenerative disease driven by pathological depositions of proteins that accumulate over decades. Compelling genetic and neurobiological evidence suggests that amyloid accumulation in the brain initiates and drives early-stage AD. Measurement of fibrillar amyloid has been pivotal to the development and approval of disease-slowing treatments. Various

Alzheimer’s disease is a complex and multifactorial disease characterized by two key pathological hallmarks: amyloid-beta plaques and tau neurofibrillary tangles. Recent progress has led to the development and approval of disease-targeted therapies for Alzheimer’s disease in the form of anti-amyloid-beta monoclonal antibodies. However, findings suggest that amelioration of multiple pathological dr

Although much progress has been made over the last decades, there is still a significant clinical need for novel therapies to manage cancer. Typical problems are that solid tumors are frequently inaccessible, aggressive, and metastatic. To contribute to solving some of these issues, we have developed a novel radioisotope-labeled 27 nm nanoparticle, 177Lu-SN201, to selectively target solid tumors v

Background: Cardiovascular diseases (CVDs) are the leading cause of mortality and are among the foremost causes of disability globally. CVD burden has continued to increase in most countries since 1990, with trends driven by changing exposures to harmful risk factors, population growth, and population aging. Objectives: We report estimates of global, national, and subnational CVD burden, including

Volume 3 of the FCC Feasibility Report presents studies related to civil engineering, the development of a project implementation scenario, and environmental and sustainability aspects. The report details the iterative improvements made to the civil engineering concepts since 2018, taking into account subsurface conditions, accelerator and experiment requirements, and territorial considerations. I

Volume 1 of the FCC Feasibility Report presents an overview of the physics case, experimental programme, and detector concepts for the Future Circular Collider (FCC). This volume outlines how FCC would address some of the most profound open questions in particle physics, from precision studies of the Higgs and EW bosons and of the top quark, to the exploration of physics beyond the Standard Model.

The T-REX neutron spectrometer at the European Spallation Source will use Multi-Grid Technology, which is a voxelised proportional counter relying on 10B4C coatings to detect neutrons scattered by the sample under investigation. Measurements of the position dependence of pulse-height and relative detection efficiency of a Multi-Grid prototype of the T-REX spectrometer are presented for two differe

Inverted perovskite solar cells (IPSCs) have emerged as promising photovoltaic technologies due to excellent photoelectric properties and solution processing advantages. However, the traditional preparation process based on inert atmosphere annealing of perovskite films faces key challenges, including high energy consumption, strict crystallization control, and the presence of stresses. The study

The effect of periodate oxidation and borohydride reduction on arabinoxylan (AX) in aqueous solution was investigated using 13C NMR spectroscopy and small-angle X-ray scattering (SAXS). AX consists of a xylose backbone, which is mono- or di-substituted with arabinose. We show that at a ring-opening modification degree of 21%, periodate oxidation occurs predominantly on arabinose, and shows a prefe

This paper examines the influence of the Efficient Markets Hypothesis (EMH) on financial regulation, using a perspective drawing on arguments from the Philosophy of Science discipline.The paper aims to show that, prior to the global financial crisis, there already existed a large body of empirically observed asset price anomalies, which may be seen to contradict the notion of elastic demand curves

Temperature, a key environmental stressor, can induce changes at the molecular levels in the body of living beings, which are necessary for adaptation and survival under altered conditions. We investigated the effects of acute cold (3 °C) and heat (32 °C) shocks on hemolymph protein profiles in marbled crayfish. Results showed that cold shock induced a metabolic shift toward glucose production by

INTRODUCTION: Genetic deficiency of factor XI is associated with a reduced risk of ischemic stroke. Asundexian is a direct inhibitor of activated factor XIa (FXIa) with a low risk of bleeding in early trials. We seek to determine its efficacy and safety combined with antiplatelet therapy for prevention of ischemic stroke. PATIENTS AND METHODS: Oral faCtor Eleven A iNhibitor asundexian as novel ant

This paper studies whether central bank collateral frameworks play a stabilising role during large redemption shocks to investment funds. Using the “dash-for-cash” of 2020 as a case study, we find that funds with a higher share of ECB-eligible corporate bonds experienced lower redemption volumes, especially those with close affiliation to banks. We also find that asset managers followed a liquidat

As Nature Aging celebrates its fifth anniversary, the journal asks some of the researchers who contributed to the journal early on to reflect on the past and the future of aging and age-related disease research, the impact of the field on human health now and in the future, and what challenges need to be addressed to ensure sustained progress. © Springer Nature America, Inc. 2026.

Temperature variability and long-term warming are increasingly threatening agricultural sustainability in southern Rwanda, where smallholder farmers rely on climate-sensitive crops. However, comprehensive spatiotemporal assessments of temperature extremes and their impacts on agriculture remain limited. This study used daily minimum and maximum temperature data from 1983 to 2021 for Huye District,

Obesity’s metabolic heterogeneity is not fully captured by body mass index (BMI). Here we show that deep multi-omics phenotyping of 1,408 individuals defines a metabolome-informed obesity metric (metBMI) that captures adipose tissue-related dysfunction across organ systems. In an external cohort (n = 466), metBMI explained 52% of BMI variance and more accurately reflected adiposity than other omic

A soft magnetic core loss tester originally designed for sinusoidal flux excitation has been modified to enable multi-level PWM excitation. The setup is used to characterize an automotive-grade stator core under magnetic flux densities and excitation frequencies up to 1.4 T and 400 Hz respectively, as well as, switching frequencies between 4 and 16 kHz, with PWM voltage levels reaching up to seven