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Muscle-invasive bladder cancer (MIBC) is characterised by significant molecular heterogeneity, with the tumour composition being further sculptured by local microenvironmental influences. This inherent complexity contributes to the divergent disease trajectories and the variable therapeutic susceptibility observed among patients. Consequently, there is an evident need for prognostic and predictive
This article analyses the role of the Soviet political police and the KGB state security in suppressing large workers' protests in Novocherkassk in 1962. The aim is not only to study the actions of the KGB during the crisis itself, but above all to show how the events in Novocherkassk contributed to the subsequent change in the overall character of this repressive service and, more generally, the This essay analyses the role of the KGB, the Soviet state security and political police, in suppressing large workers’ protests in Novocherkassk in early June 1962. The aim is not only to study the actions of the KGB during the crisis itself, but to show how events in Novocherkassk and the subsequent brutal punishment of their main actors contributed to the subsequent change in the overall charact
The last couple of years’ child/youth-led climate cases like Juliana v. US, Sacchi et al. v. Argentina et al. and the Duarte Agostinho case at the European Court of Human Rights have sparked the beginnings of a new sub-field of socio-legal child rights studies. The present paper systematically and critically reviews this emerging body of literature on rights-based climate litigation with children
Rationale: Early detection, standardized therapy, adequate infrastructure, and strategies for quality improvement should constitute essential components of every hospital’s sepsis plan. Objectives: To investigate the extent to which recommendations from the sepsis guidelines are implemented and the availability of infrastructure for the care of patients with sepsis in acute-care hospitals. Methods
Membrane filtration of kraft black liquor (KBL), a side-stream of the pulp and paper industry, is challenged by membrane fouling caused by its multicomponent complexity. The specific contributions of the components found in KBL to the fouling and the characteristics of the fouling layer that they create has not been investigated. Herein, the adsorptive and desorptive behaviours of KBL ultrafiltrat
Background: Previous studies indicate comparably greater improvement in glycaemic control from Paleolithic diet, possibly due to an accompanying greater reduction in body weight, which, in turn, could be due to an accompanying greater reduction in leptin.Aims: To assess in type 2 diabetes the effect of Paleolithic diet on glycaemic control when body weight is kept stable and diets matched for macr
PURPOSE: There is uncertainty whether ER-low tumors with a 1-10% immunohistochemical staining of nuclei represent a distinct molecular biological entity of BC, posing significant challenges for their clinical management and developing novel therapies. We aimed to elucidate ER-low tumor biology.EXPERIMENTAL DESIGN: We analyzed primary tumors included in a Swedish population-based SCAN-B BC cohort,
The coefficient of friction (COF) and wear are critical parameters in assessing disc brake performance. However, their study is challenging due to their interdependence on contact pressure, sliding velocity, temperature, and material composition. The complex contact interactions between brake pads and discs involve the continuous formation and destruction of mesoscopic contact plateaus, which
IntroductionNon-beta-haemolytic streptococci are among the most common causative agents of infective endocarditis (IE). Patients with a heart valve prosthesis (HVP) have a high risk of IE. We aimed to determine the risk for IE in patients with HVP and non-beta-haemolytic streptococcal bacteraemia (NBHSB), and to study NBHSB relapse depending on treatment duration.MethodAdults with HVP and NBHSB 20
BACKGROUND: The study aimed to describe all diagnosed cases of Legionnaire's disease (LD) in south Sweden, regarding incidence, patient characteristics, diagnostics, outcomes, and infection control investigations.METHODS: This population-based retrospective study was conducted in Skåne, on patients with LD between 2011-2021. Inclusion criteria were positive polymerase chain reaction (PCR) for L.
Neuroendocrine tumours (NETs) of the small intestine (siNET) are slow-growing malignancies often diagnosed at an advanced stage. Despite their indolent nature, patients frequently experience significant symptoms, including carcinoid syndrome (CS) with diarrhoea, which impact their health-related quality of life (HRQoL). This thesis investigates the determinants of HRQoL in siNET patients, its prog
This article conducts a multi-scalar analysis of the dynamics between secularism and religion in contemporary Sweden and highlights a growing divide between them, in the wake of neoliberal reconfigurations of the welfare state and a stronger religious pluralism in public space. Through an analysis of the public debate around conversion attempts and state funding for religious organizations, we exp
